Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs

Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination

(2022) Katharina Röltgen et al.   CELL

Prion-like Domains in Spike Protein of SARS-CoV-2 Differ across Its Variants and Enable Changes in Affinity to ACE2

(2022) George Tetz et al.   Microorganisms

COVID-19 vaccines: where we stand and challenges ahead

(2021) Guido Forni et al.   CELL DEATH AND DIFFERENTIATION

The COVID-19 mRNA Vaccines and the Pandemic: Do They Represent the Beginning of the End or the End of the Beginning?

(2021) Ravi Jhaveri   CLINICAL THERAPEUTICS

Circulating cardiovascular microRNAs in critically ill COVID ‐19 patients Short title: microRNA signatures in COVID ‐19

(2021) Ankita Garg et al.   EUROPEAN JOURNAL OF HEART FAILURE

Thrombocytopenia following Pfizer and Moderna SARS‐CoV ‐2 vaccination

(2021) Eun‐Ju Lee et al.   AMERICAN JOURNAL OF HEMATOLOGY

The intersection of genetics and COVID-19 in 2021: preview of the 2021 Rodney Howell Symposium

(2021) Sonja A. Rasmussen et al.   GENETICS IN MEDICINE

Vaccination against COVID‐19: Rationale, modalities and precautions for patients with haemophilia and other inherited bleeding disorders

(2021) Radoslaw Kaczmarek et al.   HAEMOPHILIA

Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity

(2021) Daisy A. Hoagland et al.   IMMUNITY

CNBP Binds and Unfolds In Vitro G-Quadruplexes Formed in the SARS-CoV-2 Positive and Negative Genome Strands

(2021) Georgina Bezzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

(2021) Dami A. Collier et al.   NATURE

Comprehensive assessment of humoral response after Pfizer BNT162b2 mRNA Covid-19 vaccination: a three-case series

(2021) Elisa Danese et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Neutralizing Autoantibodies to Type I IFNs in >10% of Patients with Severe COVID-19 Pneumonia Hospitalized in Madrid, Spain

(2021) Jesús Troya et al.   JOURNAL OF CLINICAL IMMUNOLOGY

SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia

(2021) Douglas B. Cines et al.   NEW ENGLAND JOURNAL OF MEDICINE

G-Quadruplexes as pathogenic drivers in neurodegenerative disorders

(2021) Ernest Wang et al.   NUCLEIC ACIDS RESEARCH

Interferon system deficiencies exacerbating severe pandemic virus infections

(2021) Silke Stertz et al.   TRENDS IN MICROBIOLOGY

SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia

(2021) Ritu Mishra et al.   Frontiers in Immunology

Cerebral venous sinus thrombosis 2 weeks after the first dose of mRNA SARS-CoV-2 vaccine

(2021) Zaitun Zakaria et al.   ACTA NEUROCHIRURGICA

A narrative review and clinical anatomy of herpes zoster infection following COVID ‐19 vaccination

(2021) Joe Iwanaga et al.   CLINICAL ANATOMY

BNT162b2 vaccine breakthrough: clinical characteristics of 152 fully vaccinated hospitalized COVID-19 patients in Israel

(2021) Tal Brosh-Nissimov et al.   CLINICAL MICROBIOLOGY AND INFECTION

Interactions of Spike-RBD of SARS-CoV-2 and Platelet Factor 4: New Insights in the Etiopathogenesis of Thrombosis

(2021) Margherita Passariello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?

(2021) Nouara Yahi et al.   JOURNAL OF INFECTION

Spike-antibody waning after second dose of BNT162b2 or ChAdOx1

(2021) Madhumita Shrotri et al.   LANCET

Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment

(2021) Shulan Qiu et al.   Molecular Neurodegeneration

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

(2021) Namit Chaudhary et al.   NATURE REVIEWS DRUG DISCOVERY

Myocarditis after Covid-19 mRNA Vaccination

(2021) Amanda K. Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

COVID-19 Vaccination-Associated Myocarditis in Adolescents

(2021) Supriya S. Jain et al.   PEDIATRICS

Human IgG and IgA responses to COVID-19 mRNA vaccines

(2021) Adam V. Wisnewski et al.   PLoS One

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

(2021) Monique G. P. van der Wijst et al.   Science Translational Medicine

SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions

(2021) Luis Fernando Saraiva Macedo Timmers et al.   Scientific Reports

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Epitranscriptomics: A New Layer of microRNA Regulation in Cancer

(2021) Veronica De Paolis et al.   Cancers

Comparative Immunogenicity of BNT162b2 mRNA Vaccine with Natural SARS-CoV-2 Infection

(2021) Mina Psichogiou et al.   Vaccines

Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines

(2021) Xuhua Xia   Vaccines

Reactivation of Varicella Zoster Virus after Vaccination for SARS-CoV-2

(2021) Mina Psichogiou et al.   Vaccines

Varicella Zoster Virus Reactivation Following COVID-19 Vaccination: A Systematic Review of Case Reports

(2021) Konstantinos Katsikas Triantafyllidis et al.   Vaccines

Hepatitis C Virus Reactivation Following COVID-19 Vaccination – A Case Report

(2021) Ruud Lensen et al.   International Medical Case Reports Journal

Increases in COVID-19 are unrelated to levels of vaccination across 68 countries and 2947 counties in the United States

(2021) S. V. Subramanian et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Nosocomial outbreak caused by the SARS-CoV-2 Delta variant in a highly vaccinated population, Israel, July 2021

(2021) Pnina Shitrit et al.   Eurosurveillance

Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer–BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines

(2021) Sandhya Bansal et al.   JOURNAL OF IMMUNOLOGY

Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients

(2021) DAVID de GONZALO-CALVO et al.   Translational Research

Acute Myocarditis Following COVID-19 mRNA Vaccination in Adults Aged 18 Years or Older

(2021) Anthony Simone et al.   JAMA Internal Medicine

Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines

(2021) Jiping Liu et al.   Cell Discovery

Rapid Progression of Angioimmunoblastic T Cell Lymphoma Following BNT162b2 mRNA Vaccine Booster Shot: A Case Report

(2021) Serge Goldman et al.   Frontiers in Medicine

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Diverse molecular functions of m6A mRNA modification in cancer

(2020) Seung Hun Han et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice

(2020) Yaping Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microstructural changes in the trigeminal nerve of patients with episodic migraine assessed using magnetic resonance imaging

(2020) Tiffani J. Mungoven et al.   JOURNAL OF HEADACHE AND PAIN

The mRNA Cap 2′-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes

(2020) Graham D. Williams et al.   mSphere

Crosstalk between Stress Granules, Exosomes, Tumour Antigens, and Immune Cells: Significance for Cancer Immunity

(2020) Vinoth Kumar Kothandan et al.   Vaccines

Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients

(2020) Nan Wang et al.   Cell Host & Microbe

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

(2020) Mark J. Mulligan et al.   NATURE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

(2020) David E. Gordon et al.   SCIENCE

Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection

(2020) Andrey V. Letarov et al.   BIOCHEMISTRY-MOSCOW

Expression of ACE2 , TMPRSS2 , and Furin in Mouse Ear Tissue, and the Implications for SARS‐CoV ‐2 Infection

(2020) Tsukasa Uranaka et al.   LARYNGOSCOPE

The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice

(2020) Elizabeth M. Rhea et al.   NATURE NEUROSCIENCE

Whole Genome Identification of Potential G-Quadruplexes and Analysis of the G-Quadruplex Binding Domain for SARS-CoV-2

(2020) Rongxin Zhang et al.   Frontiers in Genetics

The SARS-CoV-2 RNA–protein interactome in infected human cells

(2020) Nora Schmidt et al.   Nature Microbiology

Role of SIRT1 in hematologic malignancies

(2019) Fei-teng Huang et al.   Journal of Zhejiang University-SCIENCE B

Emerging Evidence of Translational Control by AU-Rich Element-Binding Proteins

(2019) Hiroshi Otsuka et al.   Frontiers in Genetics

A New Era for Rare Genetic Diseases: Messenger RNA Therapy

(2019) Paolo G.V. Martini et al.   HUMAN GENE THERAPY

Delivery of microRNAs by Extracellular Vesicles in Viral Infections: Could the News be Packaged?

(2019) Fabio Seiti Yamada Yoshikawa et al.   Cells

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of potential biomarkers of reactogenicity of licensed antiviral vaccines: randomized controlled clinical trials conducted by the BIOVACSAFE consortium

(2019) January Weiner et al.   Scientific Reports

Specific Vagus Nerve Lesion Have Distinctive Physiologic Mechanisms of Dysphagia

(2019) François D. H. Gould et al.   Frontiers in Neurology

Interferon regulatory factor 1 inactivation in human cancer

(2018) Khaldoon Alsamman et al.   BIOSCIENCE REPORTS

The IRF9-SIRT1-P53 axis is involved in the growth of human acute myeloid leukemia

(2018) Wen-Liang Tian et al.   EXPERIMENTAL CELL RESEARCH

Adenosine methylation as a molecular imprint defining the fate of RNA

(2018) Philip Knuckles et al.   FEBS LETTERS

Developing effective vaccines: Cues from natural infection

(2018) Vishakha Bhurani et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

p16 Controls p53 Protein Expression Through miR-dependent Destabilization of MDM2

(2018) Huda H. Al-Khalaf et al.   MOLECULAR CANCER RESEARCH

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Alteration in microRNA-155 level correspond to severity of coronary heart disease

(2018) Xian-Ke Qiu et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Cap-Independent Translation: What’s in a Name?

(2018) Ivan N. Shatsky et al.   TRENDS IN BIOCHEMICAL SCIENCES

RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand

(2018) Jaubert Chloé et al.   Scientific Reports

Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs

(2018) Ka Lung Chan et al.   CHEMICAL COMMUNICATIONS

Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts

(2018) Barbara Herdy et al.   NUCLEIC ACIDS RESEARCH

Peroxisome proliferator-activated receptor α attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice

(2018) Yu Lu et al.   ARCHIVES OF TOXICOLOGY

Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3′ UTRs Identified by Cellular Library Screening

(2018) Alexandra G. Orlandini von Niessen et al.   MOLECULAR THERAPY

RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms

(2017) Marta M. Fay et al.   JOURNAL OF MOLECULAR BIOLOGY

Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury

(2017) Chunxiao Wang et al.   MOLECULAR THERAPY

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

(2017) Kapil Bahl et al.   MOLECULAR THERAPY

Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X

(2017) Carika Weldon et al.   NUCLEIC ACIDS RESEARCH

Overexpression of Interferon Regulatory Factor 7 (IRF7) Reduces Bone Metastasis of Prostate Cancer Cells in Mice

(2017) Yang Zhao et al.   ONCOLOGY RESEARCH

G-Quadruplexes influence pri-microRNA processing

(2017) Samuel G. Rouleau et al.   RNA Biology

3′ UTR G-quadruplexes regulate miRNA binding

(2017) Samuel Rouleau et al.   RNA

Type-I-interferons in infection and cancer: Unanticipated dynamics with therapeutic implications

(2017) Martina Musella et al.   OncoImmunology

When your cap matters: structural insights into self vs non-self recognition of 5′ RNA by immunomodulatory host proteins

(2016) Daisy W Leung et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses

(2016) Ans De Beuckelaer et al.   MOLECULAR THERAPY

Interferon Alpha Signalling and Its Relevance for the Upregulatory Effect of Transporter Proteins Associated with Antigen Processing (TAP) in Patients with Malignant Melanoma

(2016) Ruth Heise et al.   PLoS One

BRCA1 inhibits AR–mediated proliferation of breast cancer cells through the activation of SIRT1

(2016) Wenwen Zhang et al.   Scientific Reports

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

microRNA-762 promotes breast cancer cell proliferation and invasion by targeting IRF7 expression

(2015) Yongping Li et al.   CELL PROLIFERATION

T-ALL: ALL a matter of Translation?

(2015) T. Girardi et al.   HAEMATOLOGICA

N 1 -methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

(2015) Oliwia Andries et al.   JOURNAL OF CONTROLLED RELEASE

Bell's palsy: aetiology, clinical features and multidisciplinary care

(2015) T. J. Eviston et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cytoplasmic mRNA turnover and ageing

(2015) Fivos Borbolis et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Exosomes and Their Role in the Life Cycle and Pathogenesis of RNA Viruses

(2015) Harendra Chahar et al.   Viruses-Basel

DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

(2015) Elsa Suberbielle et al.   Nature Communications

Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms

(2015) Marieke C. Verweij et al.   PLoS Pathogens

T-ALL: ALL a matter of Translation?

(2015) T. Girardi et al.   HAEMATOLOGICA

Continuous and Discontinuous RNA Synthesis in Coronaviruses

(2015) Isabel Sola et al.   Annual Review of Virology

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

The ReNAissanCe of mRNA-based cancer therapy

(2014) Sandra Van Lint et al.   Expert Review of Vaccines

Interaction between NADPH-oxidase and Rho-kinase in angiotensin II-induced microglial activation

(2014) Ana I. Rodriguez-Perez et al.   GLIA

Immune thrombocytopenic purpura (ITP) associated with vaccinations: a review of reported cases

(2014) Carlo Perricone et al.   IMMUNOLOGIC RESEARCH

G-quadruplexes within prion mRNA: the missing link in prion disease?

(2014) René C.L. Olsthoorn   NUCLEIC ACIDS RESEARCH

A critical analysis of codon optimization in human therapeutics

(2014) Vincent P. Mauro et al.   TRENDS IN MOLECULAR MEDICINE

MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability

(2014) Young Eun Choi et al.   eLife

IL6 sensitizes prostate cancer to the antiproliferative effect of IFNα2 through IRF9

(2013) Holger H H Erb et al.   ENDOCRINE-RELATED CANCER

Steroids for preventing recurrence of acute severe migraine headaches: a meta-analysis

(2013) Y. Huang et al.   EUROPEAN JOURNAL OF NEUROLOGY

The role of vagal neurocircuits in the regulation of nausea and vomiting

(2013) Tanja Babic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice

(2013) Xin-An Wang et al.   HEPATOLOGY

Non-optimal codon usage affects expression, structure and function of clock protein FRQ

(2013) Mian Zhou et al.   NATURE

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sounds of silence: synonymous nucleotides as a key to biological regulation and complexity

(2013) S. A. Shabalina et al.   NUCLEIC ACIDS RESEARCH

Opposing roles for 53BP1 during homologous recombination

(2013) Andreas Kakarougkas et al.   NUCLEIC ACIDS RESEARCH

Biosynthesis and biological function of sulfoglycolipids

(2013) Koichi HONKE   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Heterogeneous Nuclear Ribonucleoprotein A2/B1 Regulates the Self-Renewal and Pluripotency of Human Embryonic Stem Cells Via the Control of the G1/S Transition

(2013) Hong Seo Choi et al.   STEM CELLS

Renin angiotensin system: A novel target for migraine prophylaxis

(2012) Ruchika Nandha et al.   INDIAN JOURNAL OF PHARMACOLOGY

Good Codons, Bad Transcript: Large Reductions in Gene Expression and Fitness Arising from Synonymous Mutations in a Key Enzyme

(2012) Deepa Agashe et al.   MOLECULAR BIOLOGY AND EVOLUTION

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

(2012) Bradley N Bidwell et al.   NATURE MEDICINE

MicroRNAs and neurodegeneration: role and impact

(2012) Masashi Abe et al.   TRENDS IN CELL BIOLOGY

P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation

(2012) C. J. Decker et al.   Cold Spring Harbor Perspectives in Biology

Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice

(2012) Takefumi Kimura et al.   PPAR Research

Targeting the extrinsic apoptosis signaling pathway for cancer therapy

(2011) Thomas J. Sayers   CANCER IMMUNOLOGY IMMUNOTHERAPY

TRAIL death receptors as tumor suppressors and drug targets

(2011) Niklas K. Finnberg et al.   CELL CYCLE

Pervasive roles of microRNAs in cardiovascular biology

(2011) Eric M. Small et al.   NATURE

Effect of interferon-alpha-based antiviral therapy on hepatitis C virus-associated glomerulonephritis: a meta-analysis

(2011) B. Feng et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Role of p53 in Cell Death and Human Cancers

(2011) Toshinori Ozaki et al.   Cancers

Angiotensin II sustains brain inflammation in mice via TGF-β

(2010) Tobias V. Lanz et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear factor- B is a critical mediator of stress-impaired neurogenesis and depressive behavior

(2010) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS

(2009) G. Y. Oudit et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

IRF9 is a Key Factor for Eliciting the Antiproliferative Activity of IFN-α

(2009) Takaya Tsuno et al.   JOURNAL OF IMMUNOTHERAPY

Disorders of Cranial Nerves IX and X

(2009) Audrey Erman et al.   SEMINARS IN NEUROLOGY

Saffold Virus, a Human Theiler's-Like Cardiovirus, Is Ubiquitous and Causes Infection Early in Life

(2009) Jan Zoll et al.   PLoS Pathogens

Interferon regulatory factor family of transcription factors and regulation of oncogenesis

(2008) Akinori Takaoka et al.   CANCER SCIENCE

Combining tumor-targeted superantigens with interferon-alpha results in synergistic anti-tumor effects

(2008) Anette Sundstedt et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

When microRNAs activate translation

(2008) Nicole Rusk   NATURE METHODS