Chemically induced hepatotoxicity in human stem cell-induced hepatocytes compared with primary hepatocytes and HepG2

Adipose Stromal Cells are a More Efficient Source than Adipose Stem Cells in Retrovirus-Mediated iPS Induction

(2015) Seok-Jin Kang et al.   Cellular and Molecular Bioengineering

Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes

(2014) Kazuo Takayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes

(2013) S. Ogawa et al.   DEVELOPMENT

Rapid and Scalable Human Stem Cell Differentiation: Now in 3D

(2013) David C. Hay   STEM CELLS AND DEVELOPMENT

Generation of Functional Hepatocyte-Like Cells from Human Pluripotent Stem Cells in a Scalable Suspension Culture

(2013) Massoud Vosough et al.   STEM CELLS AND DEVELOPMENT

Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes

(2013) M.J.A. Jetten et al.   TOXICOLOGY IN VITRO

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

(2012) Kazuo Takayama et al.   BIOMATERIALS

Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells

(2012) M. Kajiwara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model

(2012) Rotem Ben-Shachar et al.   Theoretical Biology and Medical Modelling

Proteomics in the search for mechanisms and biomarkers of drug-induced hepatotoxicity

(2012) Anke Van Summeren et al.   TOXICOLOGY IN VITRO

Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors

(2012) Timothy A. Blauwkamp et al.   Nature Communications

Genomic indicators in the blood predict drug-induced liver injury

(2010) J Huang et al.   PHARMACOGENOMICS JOURNAL

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

(2009) Karim Si-Tayeb et al.   HEPATOLOGY

Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development

(2009) Thomas Touboul et al.   HEPATOLOGY

Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4α interaction

(2008) Yun-Ping Lim et al.   Pharmacogenetics and Genomics

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling

(2008) D. C. Hay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells

(2008) Sadhana Agarwal et al.   STEM CELLS

Efficient Differentiation of Hepatocytes from Human Embryonic Stem Cells Exhibiting Markers Recapitulating Liver Development In Vivo

(2008) David C. Hay et al.   STEM CELLS

Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes

(2008) L. Richert et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The current state of serum biomarkers of hepatotoxicity

(2007) Josef Ozer et al.   TOXICOLOGY