Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes forIn VitroToxicity Testing
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Title
Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes forIn VitroToxicity Testing
Authors
Keywords
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Journal
TOXICOLOGICAL SCIENCES
Volume 147, Issue 1, Pages 39-54
Publisher
Oxford University Press (OUP)
Online
2015-06-20
DOI
10.1093/toxsci/kfv117
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- (2014) Mohammad R. Ebrahimkhani et al. ADVANCED DRUG DELIVERY REVIEWS
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- (2014) Mandy B. Esch et al. ADVANCED DRUG DELIVERY REVIEWS
- Pluripotent stem cell-derived hepatocyte-like cells
- (2014) R.E. Schwartz et al. BIOTECHNOLOGY ADVANCES
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- (2013) M. Sgodda et al. CURRENT MOLECULAR MEDICINE
- Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells
- (2013) Su Mi Choi et al. HEPATOLOGY
- Production of hepatocyte-like cells from human pluripotent stem cells
- (2013) Nicholas R F Hannan et al. Nature Protocols
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- (2013) Kevin M. Beggs et al. TOXICOLOGICAL SCIENCES
- Highly Efficient Differentiation of Functional Hepatocytes From Human Induced Pluripotent Stem Cells
- (2013) Xiaocui Ma et al. Stem Cells Translational Medicine
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- (2013) Claire N. Medine et al. Stem Cells Translational Medicine
- 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing
- (2012) Kazuo Takayama et al. BIOMATERIALS
- Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins
- (2012) H. H. J. Gerets et al. CELL BIOLOGY AND TOXICOLOGY
- JD induced pluripotent stem cell-derived hepatocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia
- (2012) Max A. Cayo et al. HEPATOLOGY
- Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction
- (2012) Kazuo Takayama et al. JOURNAL OF HEPATOLOGY
- A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes
- (2012) Cornelia M. Smith et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Disease-Corrected Hepatocyte-Like Cells from Familial Hypercholesterolemia-Induced Pluripotent Stem Cells
- (2012) Faranak Fattahi et al. MOLECULAR BIOTECHNOLOGY
- Hepatocyte-like cells differentiated from human induced pluripotent stem cells: Relevance to cellular therapies
- (2012) Yue Yu et al. Stem Cell Research
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- (2012) Robim M. Rodrigues et al. TOXICOLOGY IN VITRO
- Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy
- (2012) Fei Yi et al. Protein & Cell
- Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection
- (2011) Takeshi Yoshida et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture
- (2011) Maria Ulvestad et al. BIOCHEMICAL PHARMACOLOGY
- Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers
- (2011) Khanit Sa-ngiamsuntorn et al. BMC BIOTECHNOLOGY
- Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol
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- (2011) R. J. Andrade et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction
- (2011) Kazuo Takayama et al. MOLECULAR THERAPY
- Translational research: 4 ways to fix the clinical trial
- (2011) Heidi Ledford NATURE
- Isolation of Primary Human Hepatocytes from Normal and Diseased Liver Tissue: A One Hundred Liver Experience
- (2011) Ricky H. Bhogal et al. PLoS One
- Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy
- (2011) S. E. Howden et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes
- (2011) M.G.L. Elferink et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- High content screening analysis of phospholipidosis: Validation of a 96-well assay with CHO-K1 and HepG2 cells for the prediction of in vivo based phospholipidosis
- (2011) F.M. van de Water et al. TOXICOLOGY IN VITRO
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- (2011) Lloyd LeCureux et al. TOXICOLOGY IN VITRO
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- (2010) L. Guo et al. DRUG METABOLISM AND DISPOSITION
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- (2010) Brandon Swift* et al. DRUG METABOLISM REVIEWS
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- (2010) Steven M. Paul et al. NATURE REVIEWS DRUG DISCOVERY
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- (2010) Arefeh Ghodsizadeh et al. Stem Cell Reviews and Reports
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