α‐Synuclein phase separation and amyloid aggregation are modulated by C‐terminal truncations

Calcium promotes α-synuclein liquid-liquid phase separation to accelerate amyloid aggregation

(2022) Shuai Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SNARE Zippering Is Suppressed by a Conformational Constraint that Is Removed by v-SNARE Splitting

(2021) Yinghui Liu et al.   Cell Reports

Influence of Lipid Membranes on α-Synuclein Aggregation

(2021) Andrii S. Kurochka et al.   ACS Chemical Neuroscience

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

(2021) Phuong H. Nguyen et al.   CHEMICAL REVIEWS

FUS-dependent liquid–liquid phase separation is important for DNA repair initiation

(2021) Brunno R. Levone et al.   JOURNAL OF CELL BIOLOGY

Calcium-dependent and -independent lipid transfer mediated by tricalbins in yeast

(2021) Tiantian Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synapsin Condensates Recruit alpha-Synuclein

(2021) Christian Hoffmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Polymorphism of Alpha-Synuclein Amyloid Fibrils Depends on Ionic Strength and Protein Concentration

(2021) Mantas Ziaunys et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Manganese promotes α-synuclein amyloid aggregation through the induction of protein phase transition

(2021) Bingkuan Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capillary flow experiments for thermodynamic and kinetic characterization of protein liquid-liquid phase separation

(2021) Emil G. P. Stender et al.   Nature Communications

The Properties of α-Synuclein Secondary Nuclei Are Dominated by the Solution Conditions Rather than the Seed Fibril Strain

(2020) Alessia Peduzzo et al.   ACS Chemical Neuroscience

Role of α-Synuclein Regions in Nucleation and Elongation of Amyloid Fiber Assembly

(2020) José Gallardo et al.   ACS Chemical Neuroscience

Carboxy‐terminal truncations of mouse α‐synuclein alter aggregation and prion‐like seeding

(2020) Zachary A. Sorrentino et al.   FEBS LETTERS

TDP-43 α-helical structure tunes liquid–liquid phase separation and function

(2020) Alexander E. Conicella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The emerging role of α-synuclein truncation in aggregation and disease

(2020) Zachary A. Sorrentino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc promotes liquid–liquid phase separation of tau protein

(2020) Virender Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liquid–liquid phase separation of type II diabetes-associated IAPP initiates hydrogelation and aggregation

(2020) Lior Pytowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein aggregation nucleates through liquid–liquid phase separation

(2020) Soumik Ray et al.   Nature Chemistry

Structures of the intrinsically disordered Aβ, tau and α-synuclein proteins in aqueous solution from computer simulations

(2020) Phuong H. Nguyen et al.   BIOPHYSICAL CHEMISTRY

Amyloid Aggregation under the Lens of Liquid–Liquid Phase Separation

(2020) Yanting Xing et al.   Journal of Physical Chemistry Letters

RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation

(2019) Xiandeng Wu et al.   MOLECULAR CELL

Liquid-liquid phase separation of tau protein: The crucial role of electrostatic interactions

(2019) Solomiia Boyko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of alpha‐synuclein posttranslational modifications on metal binding

(2019) Nazareno González et al.   JOURNAL OF NEUROCHEMISTRY

α-Synuclein aggregation at low concentrations

(2019) Kseniia Afitska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations

(2019) Xiaodan Ni et al.   JOURNAL OF MOLECULAR BIOLOGY

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

The effect of truncation on prion-like properties of α-synuclein

(2018) Makoto Terada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH

(2018) Ingrid M. van der Wateren et al.   Chemical Science

SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins

(2018) Haijia Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C-terminal truncation exacerbates the aggregation and cytotoxicity of α-Synuclein: A vicious cycle in Parkinson's disease

(2018) Liang Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Physiological C-terminal truncation of α-synuclein potentiates the prion-like formation of pathological inclusions

(2018) Zachary A. Sorrentino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-synuclein aggregation and its modulation

(2017) Dhiman Ghosh et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

C-Terminal Truncated α-Synuclein Fibrils Contain Strongly Twisted β-Sheets

(2017) Aditya Iyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

Cell Biology and Pathophysiology of α-Synuclein

(2017) Jacqueline Burré et al.   Cold Spring Harbor Perspectives in Medicine

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Behavioural deficits in transgenic mice expressing human truncated (1–120 amino acid) alpha-synuclein

(2015) Katie Hall et al.   EXPERIMENTAL NEUROLOGY

Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies

(2015) Anna Villar-Piqué et al.   JOURNAL OF NEUROCHEMISTRY

Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding

(2015) Haijia Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Models of α-synuclein aggregation in Parkinson’s disease

(2014) Rosa María Giráldez-Pérez et al.   Acta Neuropathologica Communications

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of C-terminal negative charges and tyrosine residues in fibril formation of α-synuclein

(2012) Yasutaka Izawa et al.   Brain and Behavior

α-synuclein phosphorylation and truncation are normal events in the adult human brain

(2011) G. Muntané et al.   NEUROSCIENCE

The Conformation and the Aggregation Kinetics of α-Synuclein Depend on the Proline Residues in Its C-Terminal Region

(2010) Jessika Meuvis et al.   BIOCHEMISTRY

Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology

(2010) Ayse Ulusoy et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The role of alpha-synuclein in neurotransmission and synaptic plasticity

(2010) Furong Cheng et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Detection of Transient Interchain Interactions in the Intrinsically Disordered Protein α-Synuclein by NMR Paramagnetic Relaxation Enhancement

(2010) Kuen-Phon Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

The First N-terminal Amino Acids of α-Synuclein Are Essential for α-Helical Structure Formation In Vitro and Membrane Binding in Yeast

(2009) Katherina Vamvaca et al.   JOURNAL OF MOLECULAR BIOLOGY

Conditional transgenic mice expressing C-terminally truncated human α-synuclein (αSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

(2009) João Daher et al.   Molecular Neurodegeneration

α-Synuclein Misfolding and Neurodegenerative Diseases

(2008) Vladimir Uversky   CURRENT PROTEIN & PEPTIDE SCIENCE