C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification

(2017) Ricardo Gaspar et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein

(2016) Wei Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation

(2016) Patrick Flagmeier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

(2016) Céline Galvagnion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces

(2016) James W. P. Brown et al.   Scientific Reports

The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication

(2015) Cristina Guardia-Laguarta et al.   MOVEMENT DISORDERS

Structure of the toxic core of α-synuclein from invisible crystals

(2015) Jose A. Rodriguez et al.   NATURE

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

The Synaptic Function of α-Synuclein

(2015) Jacqueline Burré   Journal of Parkinsons Disease

Acceleration of α-Synuclein Aggregation by Exosomes

(2014) Marie Grey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surface Effects on Aggregation Kinetics of Amyloidogenic Peptides

(2014) Robert Vácha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Presence of an Air–Water Interface Affects Formation and Elongation of α-Synuclein Fibrils

(2014) Silvia Campioni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

(2014) Giuliana Fusco et al.   Nature Communications

Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy

(2013) Dorothea Pinotsi et al.   NANO LETTERS

Atomic Force Microscopy under Controlled Conditions Reveals Structure of C-Terminal Region of α-Synuclein in Amyloid Fibrils

(2012) Kim K. M. Sweers et al.   ACS Nano

The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

(2012) Susanne Wegmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

(2011) Samuel I. A. Cohen et al.   JOURNAL OF CHEMICAL PHYSICS

Structured Regions of α-Synuclein Fibrils Include the Early-Onset Parkinson's Disease Mutation Sites

(2011) Gemma Comellas et al.   JOURNAL OF MOLECULAR BIOLOGY

Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-Synuclein

(2011) Katerina Levitan et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of Novel α-Synuclein Isoforms in Human Brain Tissue by using an Online NanoLC-ESI-FTICR-MS Method

(2011) Annika Öhrfelt et al.   NEUROCHEMICAL RESEARCH

α-synuclein phosphorylation and truncation are normal events in the adult human brain

(2011) G. Muntané et al.   NEUROSCIENCE

Abnormal Neurites Containing C-Terminally Truncated α-Synuclein Are Present in Alzheimer's Disease without Conventional Lewy Body Pathology

(2010) Karen A. Lewis et al.   AMERICAN JOURNAL OF PATHOLOGY

The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding

(2010) Tim Bartels et al.   BIOPHYSICAL JOURNAL

Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology

(2010) Ayse Ulusoy et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

SDS-Induced Fibrillation of α-Synuclein: An Alternative Fibrillation Pathway

(2010) Lise Giehm et al.   JOURNAL OF MOLECULAR BIOLOGY

Frequency Factors in a Landscape Model of Filamentous Protein Aggregation

(2010) Alexander K. Buell et al.   PHYSICAL REVIEW LETTERS

Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   JOURNAL OF MOLECULAR BIOLOGY

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†

(2008) Daniel Sevlever et al.   BIOCHEMISTRY

Optical Reporters for the Conformation of  -Synuclein Reveal a Specific Interaction with Mitochondria

(2008) K. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Prolyl oligopeptidase stimulates the aggregation of α-synuclein

(2008) Inger Brandt et al.   PEPTIDES

Protein secondary structure analyses from circular dichroism spectroscopy: Methods and reference databases

(2007) Lee Whitmore et al.   BIOPOLYMERS

The solubility of α-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease

(2003) Bruce C. V. Campbell et al.   JOURNAL OF NEUROCHEMISTRY