Multiple roles for basement membrane proteins in cancer progression and EMT

Basement membrane stiffness determines metastases formation

(2021) Raphael Reuten et al.   NATURE MATERIALS

Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

(2021) Yang Chen et al.   CANCER CELL

Type IV collagen as a potential biomarker of metastatic breast cancer

(2021) Moa Lindgren et al.   CLINICAL & EXPERIMENTAL METASTASIS

Non‐invasive prognostic biomarker potential of quantifying the pro‐peptides of type XI collagen alpha 1 chain ( PRO‐C11 ) in patients with pancreatic ductal adenocarcinoma

(2021) Neel I. Nissen et al.   INTERNATIONAL JOURNAL OF CANCER

Integrins as attractive targets for cancer therapeutics

(2021) Meng Li et al.   Acta Pharmaceutica Sinica B

Increased NID1 Expression among Breast Cancer Lung Metastatic Women; A Comparative Analysis between Naive and Treated Cases

(2020) Tabinda Urooj et al.   Recent Patents on Anti-Cancer Drug Discovery

Utility of Oncotype DX in Male Breast Cancer Patients and Impact on Chemotherapy Administration: A Comparative Study with Female Patients

(2020) Austin D. Williams et al.   ANNALS OF SURGICAL ONCOLOGY

Crosstalk between Epidermal Growth Factor Receptors (EGFR) and integrins in resistance to EGFR tyrosine kinase inhibitors (TKIs) in solid tumors

(2020) Samira Javadi et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Interaction between prostate cancer cells and prostate fibroblasts promotes accumulation and proteolytic processing of basement membrane proteins

(2020) Marjaana Ojalill et al.   PROSTATE

Inhibition of collagen XI alpha 1-induced fatty acid oxidation triggers apoptotic cell death in cisplatin-resistant ovarian cancer

(2020) Sameera Nallanthighal et al.   Cell Death & Disease

Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal Cancer

(2020) Cuong Cao Le et al.   Frontiers in Oncology

A mutation found in esophageal cancer alters integrin β4 mRNA splicing

(2020) Gabriel T. Kelly et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ovarian Cells Have Increased Proliferation in Response to Heparin-Binding Epidermal Growth Factor as Collagen Density Increases

(2020) Kaitlin C. Fogg et al.   TISSUE ENGINEERING PART A

Differential glycosylation of collagen modulates lung cancer stem cell subsets through β1 integrin‐mediated interactions.

(2020) Cecilia Gardelli et al.   CANCER SCIENCE

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion

(2020) David H. Peng et al.   Nature Communications

Periodontal pathogens promote cancer aggressivity via TLR/MyD88 triggered activation of Integrin/FAK signaling that is therapeutically reversible by a probiotic bacteriocin

(2020) Pachiyappan Kamarajan et al.   PLoS Pathogens

PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations

(2019) Yongshuai Jiang et al.   Human Vaccines & Immunotherapeutics

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance

(2019) Jonathan Cooper et al.   CANCER CELL

Evaluation of the diagnostic ability of laminin gene family for pancreatic ductal adenocarcinoma

(2019) Chengkun Yang et al.   Aging-US

Beyond proteases: Basement membrane mechanics and cancer invasion

(2019) Julie Chang et al.   JOURNAL OF CELL BIOLOGY

Stromal integrin α11 regulates PDGFRβ signaling and promotes breast cancer progression

(2019) Irina Primac et al.   JOURNAL OF CLINICAL INVESTIGATION

Interaction between laminin-5γ2 and integrin β1 promotes the tumor budding of colorectal cancer via the activation of Yes-associated proteins

(2019) Bijiao Zhou et al.   ONCOGENE

Laminin 332 in cancer: When the extracellular matrix turns signals from cell anchorage to cell movement

(2019) Patricia Rousselle et al.   SEMINARS IN CANCER BIOLOGY

MRTF-A mediates the activation of COL1A1 expression stimulated by multiple signaling pathways in human breast cancer cells

(2018) Chao Meng et al.   BIOMEDICINE & PHARMACOTHERAPY

Protocadherin-8 promotes invasion and metastasis via laminin subunit γ2 in gastric cancer

(2018) Ying Lin et al.   CANCER SCIENCE

Collagen prolyl hydroxylase 3 has a tumor suppressive activity in human lung cancer

(2018) Yong Li et al.   EXPERIMENTAL CELL RESEARCH

Extracellular matrix proteins as diagnostic markers of breast carcinoma

(2018) Marta Giussani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Extracellular matrix functions in lung cancer

(2018) Martin Götte et al.   MATRIX BIOLOGY

Targeting of Cell Surface Proteolysis of Collagen XVII Impedes Squamous Cell Carcinoma Progression

(2018) Célimène Galiger et al.   MOLECULAR THERAPY

EMT: Mechanisms and therapeutic implications

(2018) Mohini Singh et al.   PHARMACOLOGY & THERAPEUTICS

Tumstatin, a Matrikine Derived from Collagen Type IVα3, is Elevated in Serum from Patients with Non–Small Cell Lung Cancer

(2018) Signe Holm Nielsen et al.   Translational Oncology

SPP1 promotes ovarian cancer progression via Integrin β1/FAK/Akt signaling pathway

(2018) Biao zeng et al.   OncoTargets and Therapy

Integrin Inhibitors in Prostate Cancer

(2018) Maylein Juan-Rivera et al.   Cancers

Laminin 332 expression and prognosis in breast Cancer

(2018) Philip M. Carpenter et al.   HUMAN PATHOLOGY

Drug Resistance Driven by Cancer Stem Cells and Their Niche

(2017) Marta Prieto-Vila et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Assessment of Tumor Stiffness With Shear Wave Elastography in a Human Prostate Cancer Xenograft Implantation Model

(2017) Yiru Wang et al.   JOURNAL OF ULTRASOUND IN MEDICINE

Laminins and cancer stem cells: Partners in crime?

(2017) Yan Qin et al.   SEMINARS IN CANCER BIOLOGY

Laminin Modulates the Stem Cell Population in LM05-E Murine Breast Cancer Cells through the Activation of the MAPK/ERK Pathway

(2017) Damián E. Berardi et al.   Cancer Research and Treatment

Stratum, a Homolog of the Human GEF Mss4, Partnered with Rab8, Controls the Basal Restriction of Basement Membrane Proteins in Epithelial Cells

(2017) Olivier Devergne et al.   Cell Reports

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

(2017) Darshan S. Chandrashekar et al.   NEOPLASIA

Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling

(2016) Hua Gao et al.   CELL

Elevated integrin α6β4 expression is associated with venous invasion and decreased overall survival in non–small cell lung cancer

(2016) Rachel L. Stewart et al.   HUMAN PATHOLOGY

N-Telopeptide of Type I Collagen Long-Term Dynamics in Breast Cancer Patients With Bone Metastases: Clinical Outcomes and Influence of Extraskeletal Metastases

(2016) A. R. Ferreira et al.   ONCOLOGIST

Collagen XVII/laminin-5 activates epithelial-to-mesenchymal transition and is associated with poor prognosis in lung cancer

(2016) Chen-Chi Liu et al.   Oncotarget

Integrin α6 promotes esophageal cancer metastasis and is targeted by miR-92b

(2016) Gang Ma et al.   Oncotarget

Increased Expression of Several Collagen Genes is Associated with Drug Resistance in Ovarian Cancer Cell Lines

(2016) Radosław Januchowski et al.   Journal of Cancer

Migration of breast cancer cell lines in response to pulmonary laminin 332

(2016) Philip M. Carpenter et al.   Cancer Medicine

Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma

(2015) Sonja Berchtold et al.   CANCER LETTERS

Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis

(2015) Cole R Drifka et al.   MODERN PATHOLOGY

Analysis of colorectal cancer glyco-secretome identifies laminin β-1 (LAMB1) as a potential serological biomarker for colorectal cancer

(2015) Qifeng Lin et al.   PROTEOMICS

3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence

(2014) Kristin M. Riching et al.   BIOPHYSICAL JOURNAL

Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner

(2014) Kalle Sipilä et al.   FASEB JOURNAL

Discoidin domain receptor 2 (DDR2) promotes breast cancer cell metastasis and the mechanism implicates epithelial-mesenchymal transition programme under hypoxia

(2014) Tingting Ren et al.   JOURNAL OF PATHOLOGY

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

(2014) Thomas Powles et al.   NATURE

Serum biomarkers reflecting specific tumor tissue remodeling processes are valuable diagnostic tools for lung cancer

(2014) Nicholas Willumsen et al.   Cancer Medicine

Tamoxifen selects for breast cancer cells with mammosphere forming capacity and increased growth rate

(2013) Diego Raffo et al.   BREAST CANCER RESEARCH AND TREATMENT

Identification of candidate circulating cisplatin-resistant biomarkers from epithelial ovarian carcinoma cell secretomes

(2013) P-N Teng et al.   BRITISH JOURNAL OF CANCER

Collagen type XI α1 facilitates head and neck squamous cell cancer growth and invasion

(2013) J C Sok et al.   BRITISH JOURNAL OF CANCER

A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer

(2013) Dong-Joo Cheon et al.   CLINICAL CANCER RESEARCH

Assessment of Laminin-5 in Oral Dysplasia and Squamous Cell Carcinoma

(2013) Vidya Rani et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Up-regulation of type I collagen during tumorigenesis of colorectal cancer revealed by quantitative proteomic analysis

(2013) Xia Zou et al.   Journal of Proteomics

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

(2013) Kun Zhang et al.   NATURE CELL BIOLOGY

Overexpression of COL11A1 by Cancer-Associated Fibroblasts: Clinical Relevance of a Stromal Marker in Pancreatic Cancer

(2013) Carmen García-Pravia et al.   PLoS One

Collagen VI in cancer and its biological mechanisms

(2013) Peiwen Chen et al.   TRENDS IN MOLECULAR MEDICINE

Laminins in basement membrane assembly

(2013) Erhard Hohenester et al.   Cell Adhesion & Migration

Laminin-111-derived peptides and cancer

(2013) Yamato Kikkawa et al.   Cell Adhesion & Migration

Clinicopathological significance of laminin-5γ2 chain expression in superficial esophageal cancer

(2012) E. Ito et al.   DISEASES OF THE ESOPHAGUS

Adipocyte-derived endotrophin promotes malignant tumor progression

(2012) Jiyoung Park et al.   JOURNAL OF CLINICAL INVESTIGATION

RETFusions Define a Unique Molecular and Clinicopathologic Subtype of Non–Small-Cell Lung Cancer

(2012) Rui Wang et al.   JOURNAL OF CLINICAL ONCOLOGY

Wild-Type p53 Attenuates Cancer Cell Motility by Inducing Growth Differentiation Factor-15 Expression

(2011) Jung-Chien Cheng et al.   ENDOCRINOLOGY

N-telopeptide of type I collagen is useful for monitoring therapeutic response in non-small cell lung cancer patients with bone metastases

(2010) Rieko Kaira et al.   International Journal of Clinical Oncology

A Potential Role of Collagens Expression in Distinguishing Between Premalignant and Malignant Lesions in Stomach

(2009) Yuan Zhao et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Cancer progression is associated with increased expression of basement membrane proteins in three-dimensional in vitro models of human oral cancer

(2009) Keerthi K. Kulasekara et al.   ARCHIVES OF ORAL BIOLOGY

A gene expression signature that defines breast cancer metastases

(2009) Rachel E. Ellsworth et al.   CLINICAL & EXPERIMENTAL METASTASIS

The Differential Effect of Endothelial Cell Factors on In Vitro Motility of Malignant and Non-malignant Cells

(2008) Adele Wright et al.   ANNALS OF BIOMEDICAL ENGINEERING

Laminin-332-Integrin Interaction: A Target For Cancer Therapy?

(2008) Daisuke Tsuruta et al.   CURRENT MEDICINAL CHEMISTRY

Collagen XVII/BP180 Protein Expression in Squamous Cell Carcinoma of the Skin Detected With Novel Monoclonal Antibodies in Archived Tissues Using Tissue Microarrays and Digital Microscopy

(2008) Eva Stelkovics et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY