Basement membrane stiffness determines metastases formation

Are 90% of deaths from cancer caused by metastases?

(2019) Hanna Dillekås et al.   Cancer Medicine

Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D

(2019) Alejandro E Mayorca-Guiliani et al.   Nature Protocols

Cancer cells’ ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential

(2018) Lena Wullkopf et al.   MOLECULAR BIOLOGY OF THE CELL

Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments

(2018) Katrina M. Wisdom et al.   Nature Communications

ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix

(2017) Alejandro E Mayorca-Guiliani et al.   NATURE MEDICINE

Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

(2017) Alexandros Glentis et al.   Nature Communications

Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers

(2017) Oliver M.T. Pearce et al.   Cancer Discovery

SnapShot: Mechanosensing Matrix

(2016) Jerome Irianto et al.   CELL

Structural and mechanical properties of the proliferative zone of the developing murine growth plate cartilage assessed by atomic force microscopy

(2016) Carina Prein et al.   MATRIX BIOLOGY

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes

(2016) Raphael Reuten et al.   Nature Communications

Identifying and targeting determinants of melanoma cellular invasion

(2016) Aparna Jayachandran et al.   Oncotarget

The Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration

(2016) Andrea A. Villanueva et al.   Oncotarget

Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines

(2015) Eric Kowarz et al.   Biotechnology Journal

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer

(2015) C. N. Johnstone et al.   Disease Models & Mechanisms

Phonons and elasticity in critically coordinated lattices

(2015) T C Lubensky et al.   REPORTS ON PROGRESS IN PHYSICS

Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer

(2015) Bin Lv et al.   Oncotarget

Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines

(2015) Eric Kowarz et al.   Biotechnology Journal

The Acinar Cage: Basement Membranes Determine Molecule Exchange and Mechanical Stability of Human Breast Cell Acini

(2015) Aljona Gaiko-Shcherbak et al.   PLoS One

Netrin-4 Promotes Glioblastoma Cell Proliferation through Integrin β4 Signaling

(2015) Yizhou Hu et al.   NEOPLASIA

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

(2014) Tobias Bald et al.   NATURE

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

Crosstalk elimination in the detection of dual-beam optical tweezers by spatial filtering

(2014) Dino Ott et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

NETRIN-4 Protects Glioblastoma Cells FROM Temozolomide Induced Senescence

(2013) Li Li et al.   PLoS One

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Protein composition and biomechanical properties of in vivo-derived basement membranes

(2013) Willi Halfter et al.   Cell Adhesion & Migration

The expression and function of netrin-4 in murine ocular tissues

(2012) Yong N. Li et al.   EXPERIMENTAL EYE RESEARCH

Netrin-4 Delays Colorectal Cancer Carcinomatosis by Inhibiting Tumor Angiogenesis

(2011) Clarisse Eveno et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

The Matrisome:In SilicoDefinition andIn VivoCharacterization by Proteomics of Normal and Tumor Extracellular Matrices

(2011) Alexandra Naba et al.   MOLECULAR & CELLULAR PROTEOMICS

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Netrin-4 induces lymphangiogenesis in vivo

(2010) F. Larrieu-Lahargue et al.   BLOOD

Dasatinib Inhibits the Development of Metastases in a Mouse Model of Pancreatic Ductal Adenocarcinoma

(2010) Jennifer P. Morton et al.   GASTROENTEROLOGY

Basement Membranes: Cell Scaffoldings and Signaling Platforms

(2010) P. D. Yurchenco   Cold Spring Harbor Perspectives in Biology

Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer

(2009) Tomoko Fujikane et al.   BREAST CANCER RESEARCH AND TREATMENT

Invadosomes at a glance

(2009) S. Linder   JOURNAL OF CELL SCIENCE

Determining the mechanical properties of human corneal basement membranes with atomic force microscopy

(2009) Julie A. Last et al.   JOURNAL OF STRUCTURAL BIOLOGY

Netrin-4 regulates angiogenic responses and tumor cell growth

(2008) Mariana Nacht et al.   EXPERIMENTAL CELL RESEARCH

Researching into the cellular shape, volume and elasticity of mesenchymal stem cells, osteoblasts and osteosarcoma cells by atomic force microscopy

(2008) Denitsa Docheva et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation

(2008) Shigeru Sato et al.   NATURE NEUROSCIENCE