Article
Medicine, General & Internal
Agnieszka Lugowska, Galina Baydakova, Alex Ilyushkina, Ekaterina Zakharova, Hanna Mierzewska, Krystyna Szymanska, Jolanta Wierzba, Jolanta Kubalska, Alla Graban, Tomasz Kmiec, Barbara Perkowska-Sumila, Anna Tylki-Szymanska, Malgorzata Bednarska-Makaruk
Summary: Elevated DPP-IV activity was found in patients with various LSDs, with the most significant increases seen in specific types of mucolipidosis, alpha-mannosidosis, and mucopolysaccharidoses. DPP-IV may serve as a valuable diagnostic tool and subject for further study in the understanding of LSDs.
Article
Andrology
Shi-Wen Liu, Hui-Tao Li, Ren-Shan Ge, C. Yan Cheng
Summary: Studies have shown that the NC1 peptide of collagen alpha 3 (IV) chains can promote remodeling of the blood-testis barrier and release of sperm from the seminiferous epithelium. This bioactive peptide disrupts cytoskeletal organization by activating a signaling cascade involving multiple proteins, ultimately modulating spermatogenesis.
ASIAN JOURNAL OF ANDROLOGY
(2021)
Article
Cell Biology
Jean-Baptiste Oudart, Matthieu Villemin, Bertrand Brassart, Christele Sellier, Christine Terryn, Aurelie Dupont-Deshorgue, Jean Claude Monboisse, Francois-Xavier Maquart, Laurent Ramont, Sylvie Brassart-Pasco
Summary: In this study, we found that the F4 peptide derived from collagen XIX has anti-angiogenic properties by inhibiting VEGF-induced tube formation by endothelial cells and endothelial sprouting in aortic ring assay. We also identified integrins alpha v beta 3 and alpha 5 beta 1 as potential receptors for F4, suggesting a direct interaction between F4 and these integrins, which contributes to its antitumor effects.
CELL ADHESION & MIGRATION
(2021)
Review
Polymer Science
Zahra Rajabimashhadi, Nunzia Gallo, Luca Salvatore, Francesca Lionetto
Summary: Fish collagen has gained attention in recent decades for its potential applications in various health-related industries. Its advantages over mammalian-based collagen, such as reduced zoonosis transmission risk and cost-effective manufacturing process, have led to the expansion of using collagen derived from fish wastes. This review summarizes the recent advances in extracting collagen from fish industry wastes for several applications and discusses the challenges in the fish-collagen market.
Article
Multidisciplinary Sciences
Hakan Ceylan, Nihal Olcay Dogan, Immihan Ceren Yasa, Mirac Nur Musaoglu, Zeynep Umut Kulali, Metin Sitti
Summary: This study proposes a personalized approach using patient blood-derivable biomaterials to construct wireless medical micromachines, aiming to alleviate safety risks from biocompatibility issues. The micro-machines demonstrated in this study exhibit multi-responsive and pH-responsive functions for controlled cargo delivery and release applications. The use of proteinaceous fabrics also enables enzymatic degradability, lowering potential risks of long-term toxicity.
Article
Biochemistry & Molecular Biology
Salome M. Brutsch, Elizabeta Madzharova, Sophia Pantasis, Till Wustemann, Selina Gurri, Heiko Steenbock, Amiq Gazdhar, Gisela Kuhn, Peter Angel, Saverio Bellusci, Juergen Brinckmann, Ulrich auf dem Keller, Sabine Werner, Mattia R. Bordoli
Summary: Vertebrate lonesome kinase (VLK) is a secreted tyrosine kinase that phosphorylates various secretory pathway-resident and extracellular matrix proteins. However, its specific functions in vivo are still largely unknown. In this study, mice lacking the VLK gene in mesenchymal cells were generated, leading to lung abnormalities and respiratory failure in most homozygous mice. Proteomics analysis revealed differential abundance of extracellular matrix proteins in the lungs of these mice, suggesting that mesenchyme-derived VLK regulates lung development through modulation of matrix dynamics and alveolar epithelial cell differentiation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cell & Tissue Engineering
Hyun-Ji Lee, Yu-Hee Kim, Da-Won Choi, Kyung-Ah Cho, Joo-Won Park, Sang-Jin Shin, Inho Jo, So-Youn Woo, Kyung-Ha Ryu
Summary: The tonsil-derived MSCs enhance BMC engraftment through secretion of MMP3 which modulates the bone marrow extracellular matrix.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Yi-Hao Yen, Kwong-Ming Kee, Wei-Feng Li, Yueh-Wei Liu, Chih-Chi Wang, Tsung-Hui Hu, Ming-Chao Tsai, Chih-Yun Lin
Summary: This study found that 51.2% of HCC patients had elevated AFP levels, and this proportion remained stable from 2011 to 2020. The proportion of early-stage HCC decreased during this period, while the proportion of NBNC-HCC increased. Advanced tumor stage, severe underlying liver disease, viral etiology, and female gender were associated with elevated AFP levels in HCC patients.
Article
Chemistry, Applied
Long He, Xinyue Wang, Yanru Wang, Jin Luo, Yining Zhao, Guangxing Han, Ling Han, Qunli Yu
Summary: The present study investigates the effects of different preparation conditions on the activity and peptide sequence identification of DPP-IV inhibitory peptides derived from discarded cowhide collagen and its regulation mechanism. The highest DPP-IV inhibitory activity was achieved through double enzymatic hydrolysis and optimized IL-US pretreatment. IL-US pretreatment induced the exposure of active sites and hydrophobic amino acids, promoted structural transformation, and enhanced gastrointestinal stability. Seven new peptides with DPP-IV inhibitory ability were identified, and five peptides were proposed as potential antidiabetic peptides from cowhide collagens.
Article
Oncology
Xinying Li, Cen Chen, Zimu Wang, Jiaxin Liu, Wei Sun, Kaikai Shen, Yanling Lv, Suhua Zhu, Ping Zhan, Tangfeng Lv, Yong Song
Summary: The study indicated that exosomal miRNAs participate in osimertinib resistance mechanisms through the activation of bypass pathways (RAS-MAPK pathway abnormality and PI3K pathway activation). Increased expression levels of exosome-derived miR-184 and miR-3913-5p may serve as biomarkers for osimertinib resistance in NSCLC patients.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Mehmet Nizamoglu, Janette K. Burgess
Summary: Disruption of cell:matrix interactions in the lung ECM is a key element in lung diseases. Lung ECM-derived hydrogels have emerged as a model system that reflects native lung physiology and can be used for studying lung diseases. However, the full potential of these hydrogels has not yet been realized.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Peter G. Chiarelli, Jinru Chen, Ronald B. Pegg, Kevin Mis Solval
Summary: This study investigated the effect of demineralization on the physicochemical properties of hydrolyzed collagen from cannonball jellyfish. Demineralization significantly reduced mineral content and increased protein content, resulting in enhanced gelling and thickening properties of the gelatin powders. Gelatin solutions prepared with demineralized powders showed higher strength and viscosity. This study highlights the importance of demineralization in producing functional gelatin powders from cannonball jellyfish.
Article
Chemistry, Medicinal
Eleonora Tassara, Boaz Orel, Micha Ilan, Dario Cavallo, Andrea Dodero, Maila Castellano, Silvia Vicini, Marco Giovine, Marina Pozzolini
Summary: This study investigates the molecular and chemical-physical properties of collagen extracted from Chondrosia reniformis sponges collected in different seasons to evaluate the potential impact of sea temperature. The results show that collagen fibrils extracted from samples at 17 degrees C have lower lysyl-hydroxylation level, thermal stability, and protein glycosylation level compared to those extracted from samples at 27 degrees C. Membranes made from 17 degrees C fibrils exhibit higher stiffness than those made from 27 degrees C fibrils. The differences in collagen properties are important in guiding the use of the biomaterial.
Article
Biochemistry & Molecular Biology
Haisheng Lin, Zhihong Zheng, Jianjun Yuan, Chaohua Zhang, Wenhong Cao, Xiaoming Qin
Summary: Marine collagen peptides derived from Sipunculus nudus (SNCP) have been found to promote skin wound healing by reducing inflammation, improving collagen deposition and recombination, and blocking the TGF-β/Smads signaling pathway, thus inhibiting scar formation. The study demonstrated that SNCP accelerates wound healing, induces cell proliferation and migration, and exhibits scar-free healing effects, suggesting potential clinical applications in skin wound repair and scar inhibition.
Article
Biology
Ryuichiro Hirayama, Kosuke Toyohara, Kei Watanabe, Takeya Otsuki, Toshikazu Araoka, Shin-Ichi Mae, Tomoko Horinouchi, Tomohiko Yamamura, Keisuke Okita, Akitsu Hotta, Kazumoto Iijima, Kandai Nozu, Kenji Osafune
Summary: This study developed kidney organoid models from AS patient iPSCs, which restored collagen alpha 5(IV) protein expression and recapitulated the differences in collagen composition between AS cases. A chemical chaperone was also found to potentially correct GBM abnormalities in the kidney organoids.
COMMUNICATIONS BIOLOGY
(2023)
Article
Allergy
Casper-Emil Tingskov Pedersen, Anders Ulrik Eliasen, Matthias Ketzel, Jorgen Brandt, Steffen Loft, Lise Marie Frohn, Jibran Khan, Susanne Brix, Morten A. Rasmussen, Jakob Stokholm, Bo Chawes, Andreanne Morin, Carole Ober, Hans Bisgaard, Marie Pedersen, Klaus Bonnelykke
Summary: Prenatal exposure to ambient air pollution is associated with immune perturbations in early life, increasing the risk of allergic rhinitis and asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Dermatology
O. Yelamos, D. Andersen, M. Pont, P. Iglesias, M. Potrony, M. Dominguez, A. Herrero, B. Alejo, J. Mateu, M. Ropke, N. B. Danneskiold-Samsoe, J. Malvehy, R. H. Guy, S. Brix, S. Puig
Summary: We developed a minimally invasive and image-guided tape stripping method for sampling atopic skin in children. This method is safe, reliable, and provides reproducible acquisition of cDNA. By comparing and optimizing skin tape stripping procedures using multiple imaging techniques, we successfully established a protocol that produced good cDNA yield without significant adverse events in a shorter time compared to previous methods. This minimally invasive method enables rapid sample collection, which is crucial in clinical practice.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Michaela Neprasova, Dita Maixnerova, Nadja Sparding, Federica Genovese, Morten Asser Karsdal, Helena Koprivova, Marek Kollar, Miloslav Suchanek, Zdenka Hruskova, Vladimir Tesar
Summary: By evaluating biomarkers related to kidney fibrosis, we can predict the outcome of patients with IgA nephropathy (IgAN). Clinical parameters and histological findings can be used to predict the kidney outcome. Biomarkers of collagen and laminin turnover in serum and urine can significantly differentiate IgAN patients with a worse prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Yuan Gao, Jakob Stokholm, Martin O'Hely, Anne-Louise Ponsonby, Mimi L. K. Tang, Sarath Ranganathan, Richard Saffery, Leonard C. Harrison, Fiona Collier, Lawrence Gray, David Burgner, John Molloy, Peter D. Sly, Susanne Brix, Hanne Frokiaer, Peter Vuillermin
Summary: Having older siblings can decrease the risk of IgE-mediated food allergy by accelerating the maturation of the infant gut microbiota.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Maryia Khomich, Huang Lin, Andrei Malinovschi, Susanne Brix, Lucia Cestelli, Shyamal Peddada, Ane Johannessen, Carsten Eriksen, Francisco Gomez Real, Cecilie Svanes, Randi Jacobsen Bertelsen
Summary: This study investigated the association between oral microbiota composition and fractional exhaled nitric oxide (F-eNO) levels. The overall composition of oral bacteria was found to be significantly associated with increasing F-eNO levels, and 27 bacterial genera showed differences between individuals with high F-eNO and low F-eNO levels. Hexa- and penta-acylated LPS producers accounted for 2.4% and 40.8% of the oral bacterial genera, respectively. The similarity within each community and F-eNO levels were associated with increasing F-eNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high F-eNO.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Daniel Andersen, Janne Marie Moll, Pankaj Arora, Niels Banhos Danneskiold-Samsoe, Si Brask Sonne, Christopher Thomas Workman, Andrew Richard Williams, Karsten Kristiansen, Susanne Brix
Summary: Intestinal tuft cells and immune responses were examined in mice fed a high-fat diet and gavaged with helminth PCF. Helminth PCF upregulated gene expression in tuft cells and increased levels of innate lymphoid cells and eosinophils. Network analyses revealed immunometabolic cues linking tuft cell response to fat mass ratio and eosinophils in eWAT to body fat mass regulation.
PARASITE IMMUNOLOGY
(2023)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Medical Laboratory Technology
Annika Hummersgaard Hansen, Helene Wallem Breisnes, Thomas Skovhus Prior, Ole Hilberg, Daniel Guldager Kring Rasmussen, Federica Genovese, Marie Vestergaard Lukassen, Birte Svensson, Lasse L. ocke Langholm, Tina Manon-Jensen, Morten Asser Karsdal, Diana Julie Leeming, Elisabeth Bendstrup, Jannie Marie Billow Sand
Summary: This study developed the FN-EDB assay for the serological assessment of MMP-8 degradation of EDB in cellular FN. It found that the degradation of EDB in cellular FN is elevated in IPF patients and further investigation is warranted.
CLINICAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Federica Genovese, Peder Frederiksen, Anne-Christine Bay-Jensen, Morten A. Karsdal, Anna M. Milan, Birgitta Olsson, Mattias Rudebeck, James A. Gallagher, Lakshminarayan R. Ranganath
Summary: Nitisinone treatment affects biomarkers of joint tissue remodelling in AKU patients, providing insights into the disease pathogenesis and treatment effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Katherine R. R. Tuttle, Jonathan M. Wilson, Yanzhu Lin, Hui-Rong Qian, Federica Genovese, Morten A. Karsdal, Kevin L. L. Duffin, Fady T. Botros
Summary: In the AWARD-7 study, once-weekly dulaglutide treatment in patients with type 2 diabetes and chronic kidney disease demonstrated a slower decline in eGFR and a reduction in urine albumin/creatinine ratio compared to insulin glargine. This exploratory analysis found that dulaglutide treatment was associated with lower levels of PRO-C6 and higher levels of C3M, indicating reduced type VI collagen formation and increased type III collagen degradation, suggesting a potential mechanism for reducing kidney fibrosis.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Rheumatology
S. Holm Nielsen, C. Magee, S. S. Groen, D. Sinkeviciute, A. C. Bay-Jensen, M. A. Karsdal, S. R. Pennington, O. FitzGerald
Summary: This study investigated collagen biomarkers and their potential use in differentiating patients with psoriatic arthritis (PsA), cutaneous psoriasis (PsC), and healthy controls. The results suggest that these biomarkers are dysregulated in PsA and PsC patients compared to healthy controls, and may potentially serve as indicators of joint involvement.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Marie Vibeke Vestergaard, Kristine H. Allin, Carsten Eriksen, Oliwia Zakerska-Banaszak, Ramesh P. Arasaradnam, Mohammad T. Alam, Karsten Kristiansen, Susanne Brix, Tine Jess
Summary: This study re-analyzed fecal microbiota data from 45 cohorts of inflammatory bowel disease (IBD) patients. The analysis identified a large number of genera associated with IBD, providing potential new treatment targets.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Alexandra Louise Moller, Stefanie Thoeni, Felix Keller, Samir Sharifli, Daniel Guldager Kring Rasmussen, Federica Genovese, Morten Asser Karsdal, Gert Mayer
Summary: This study investigated the effect of combination therapy of renin-angiotensin system inhibition and sodium-glucose co-transporter-2 inhibitors on endotrophin levels in individuals with type 2 diabetes. The results showed that combination therapy led to a significant reduction in endotrophin levels and a lower risk of kidney disease progression.
Article
Cell Biology
Liang Sun, Zhiming Li, Caiyou Hu, Jiahong Ding, Qi Zhou, Guofang Pang, Zhu Wu, Ruiyue Yang, Shenghui Li, Jian Li, Jianping Cai, Yuzhe Sun, Rui Li, Hefu Zhen, Shuqin Sun, Jianmin Zhang, Mingyan Fang, Zhihua Chen, Yuan Lv, Qizhi Cao, Yanan Sun, Ranhui Gong, Zezhi Huang, Yong Duan, Hengshuo Liu, Jun Dong, Junchun Li, Jie Ruan, Haorong Lu, Benjin He, Ninghu Li, Tao Li, Wenbin Xue, Yan Li, Juan Shen, Fan Yang, Cheng Zhao, Qinghua Liang, Mingrong Zhang, Chen Chen, Huan Gong, Yong Hou, Jian Wang, Ying Zhang, Huanming Yang, Shida Zhu, Liang Xiao, Zhen Jin, Haiyun Guo, Peng Zhao, Susanne Brix, Xun Xu, Huijue Jia, Karsten Kristiansen, Ze Yang, Chao Nie
Summary: This study analyzed the gut microbiota and serum metabolome of individuals from a Chinese longevity cohort, as well as two other aging cohorts, and discovered age-dependent differences in both microbiota and serum metabolome. They also found potential causal relationships between specific gut microbes and serum metabolite markers related to impaired renal function and aging. The findings provide valuable insights into the effects of microbiota-metabolite interplay on renal function and healthy aging.
Article
Anesthesiology
Lukas Balsevicius, Paulo C. M. Urbano, Rune Petring Hasselager, Ahmed Abdirahman Mohamud, Maria Olausson, Melina Svraka, Kirsten L. Wahlstrom, Carolin Oppermann, Dilara Seyma Gogenur, Emma Rosenkrantz Holmich, Britt Cappelen, Susanne Gjorup Saekmose, Katrine Tanggaard, Thomas Litman, Jens Borglum, Susanne Brix, Ismail Gogenur
Summary: This study aimed to investigate the effect of bilateral anterior quadratus lumborum nerve block on the immune response. The results showed that performing bilateral anterior quadratus lumborum nerve block does not alter the systemic immune response after laparoscopic hemicolectomy.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)