Journal
ACTA PHARMACEUTICA SINICA B
Volume 11, Issue 9, Pages 2726-2737Publisher
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2021.01.004
Keywords
Integrins; Extracellular matrix; Tumor progression; Targeted drug; Antagonists; Clinical trial
Categories
Funding
- National Major Scientific and Technological Special Project for Significant New Drugs Development in China [2018ZX09101001-003]
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Integrins are crucial transmembrane receptors involved in various human physiological and pathological processes, particularly in cell interactions and tumor metastasis. Targeting integrins has shown promise in cancer treatment, with integrin antagonists playing a significant role in clinical therapy development.
Integrins are transmembrane receptors that have been implicated in the biology of various human physiological and pathological processes. These molecules facilitate cell-extracellular matrix and cell-cell interactions, and they have been implicated in fibrosis, inflammation, thrombosis, and tumor metastasis. The role of integrins in tumor progression makes them promising targets for cancer treatment, and certain integrin antagonists, such as antibodies and synthetic peptides, have been effectively utilized in the clinic for cancer therapy. Here, we discuss the evidence and knowledge on the contribution of integrins to cancer biology. Furthermore, we summarize the clinical attempts targeting this family in anti-cancer therapy development. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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