Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease

Direct binding of ESCRT protein Chm7 to phosphatidic acid–rich membranes at nuclear envelope herniations

(2021) David J. Thaller et al.   JOURNAL OF CELL BIOLOGY

Sealing holes in cellular membranes

(2021) Yan Zhen et al.   EMBO JOURNAL

The ESCRT-III isoforms CHMP2A and CHMP2B display different effects on membranes upon polymerization

(2021) Maryam Alqabandi et al.   BMC BIOLOGY

Principles of membrane remodeling by dynamic ESCRT-III polymers

(2021) Anna-Katharina Pfitzner et al.   TRENDS IN CELL BIOLOGY

Efficient immunogenic peptide antigen delivery to dendritic cells using an ESCRT-mediated extracellular vesicle formation method

(2021) Sakika Kimura et al.   VACCINE

Final Exon Frameshift Biallelic PTPN23 Variants Are Associated with Microcephalic Complex Hereditary Spastic Paraplegia

(2021) Reham Khalaf-Nazzal et al.   Brain Sciences

Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily

(2021) Jiwei Liu et al.   CELL

PspA adopts an ESCRT-III-like fold and remodels bacterial membranes

(2021) Benedikt Junglas et al.   CELL

CDK1 controls CHMP7-dependent nuclear envelope reformation

(2021) Alberto T Gatta et al.   eLife

Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress

(2021) Moona Huttunen et al.   Life Science Alliance

Synthetic lethality between VPS 4A and VPS 4B triggers an inflammatory response in colorectal cancer

(2020) Ewelina Szymańska et al.   EMBO Molecular Medicine

Mechanisms of negative membrane curvature sensing and generation by ESCRT III subunit Snf7

(2020) Binod Nepal et al.   PROTEIN SCIENCE

Host ESCRT factors are recruited during Chikungunya virus infection and are required during the intracellular viral replication cycle

(2020) Shiho Torii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation

(2020) Alexander von Appen et al.   NATURE

Membrane constriction and thinning by sequential ESCRT-III polymerization

(2020) Henry C. Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission

(2020) Thomas G. Flower et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Autosomal dominant hereditary spastic paraplegia caused by mutation of UBAP1

(2020) Jianda Wang et al.   NEUROGENETICS

Anisotropic ESCRT-III architecture governs helical membrane tube formation

(2020) Joachim Moser von Filseck et al.   Nature Communications

Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation

(2020) Aurélie Bertin et al.   Nature Communications

ESCRT puts its thumb on the nanoscale: Fixing tiny holes in endolysosomes

(2020) Kevin P. Bohannon et al.   CURRENT OPINION IN CELL BIOLOGY

Human Cytomegalovirus Utilizes Extracellular Vesicles To Enhance Virus Spread

(2020) Nicholas T. Streck et al.   JOURNAL OF VIROLOGY

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation

(2020) Marina Vietri et al.   NATURE CELL BIOLOGY

An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission

(2020) Anna-Katharina Pfitzner et al.   CELL

Ik2/TBK1 and Hook/Dynein, an adaptor complex for early endosome transport, are genetic modifiers of FTD-associated mutant CHMP2B toxicity in Drosophila

(2020) Yubing Lu et al.   Scientific Reports

Structure and assembly of ESCRT-III helical Vps24 filaments

(2020) Stefan T. Huber et al.   Science Advances

De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment

(2020) Catherine Rodger et al.   AMERICAN JOURNAL OF HUMAN GENETICS

VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects

(2020) Katie G. Seu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Membrane Remodeling: ESCRT-III Filaments as Molecular Garrotes

(2020) John McCullough et al.   CURRENT BIOLOGY

SATB2‐LEMD2 interaction links nuclear shape plasticity to regulation of cognition‐related genes

(2020) Patrick Feurle et al.   EMBO JOURNAL

Loss of HCRP1 leads to upregulation of PD-L1 via STAT3 activation and is of prognostic significance in EGFR-dependent cancer

(2020) Erwin Tomasich et al.   Translational Research

An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system

(2019) David J Thaller et al.   eLife

VPS4 triggers constriction and cleavage of ESCRT-III helical filaments

(2019) Sourav Maity et al.   Science Advances

Correlative single-molecule localization microscopy and electron tomography reveals endosome nanoscale domains

(2019) Christian Franke et al.   TRAFFIC

CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation

(2019) Chang Jiang et al.   Cell Reports

Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly

(2019) Sudeep Banjade et al.   eLife

Phenotype and mutation expansion of the PTPN23 associated disorder characterized by neurodevelopmental delay and structural brain abnormalities

(2019) Renee Bend et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Vps28 Is Involved in the Intracellular Trafficking of Awd, the Drosophila Homolog of NME1/2

(2019) Elisa Mezzofanti et al.   Frontiers in Physiology

Expression of a human variant of CHMP2B linked to neurodegeneration in Drosophila external sensory organs leads to cell fate transformations associated with increased Notch activity

(2019) Caroline Wilson et al.   Developmental Neurobiology

The ESCRT-0 Protein HRS Interacts with the Human T Cell Leukemia Virus Type 2 Antisense Protein APH-2 and Suppresses Viral Replication

(2019) Fanny Martini et al.   JOURNAL OF VIROLOGY

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endocytic sorting and downregulation of the M2 acetylcholine receptor is regulated by ubiquitin and the ESCRT complex

(2019) Dmitry Zenko et al.   NEUROPHARMACOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Guided by curvature: shaping cells by coupling curved membrane proteins and cytoskeletal forces

(2018) N. S. Gov   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation

(2018) Eva Maria Wenzel et al.   Nature Communications

Timing of ESCRT-III protein recruitment and membrane scission during HIV-1 assembly

(2018) Daniel S Johnson et al.   eLife

Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes

(2018) John McCullough et al.   Annual Review of Cell and Developmental Biology

Effect of tau-pathology on charged multivesicular body protein 2b (CHMP2B)

(2018) Jiwana Sherin Midani-Kurçak et al.   BRAIN RESEARCH

Membrane bending by protein crowding is affected by protein lateral confinement

(2016) Jure Derganc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission

(2016) Liliane Christ et al.   JOURNAL OF CELL BIOLOGY

Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein

(2016) Brian J. McMillan et al.   Cell Reports

ESCRTs are everywhere

(2015) J. H. Hurley   EMBO JOURNAL

ESCRT-III controls nuclear envelope reformation

(2015) Yolanda Olmos et al.   NATURE

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

Negative membrane curvature catalyzes nucleation of endosomal sorting complex required for transport (ESCRT)-III assembly

(2015) Il-Hyung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and membrane remodeling activity of ESCRT-III helical polymers

(2015) J. McCullough et al.   SCIENCE

Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments

(2015) Shaogeng Tang et al.   eLife

A Unique Plant ESCRT Component, FREE1, Regulates Multivesicular Body Protein Sorting and Plant Growth

(2014) Caiji Gao et al.   CURRENT BIOLOGY

Membrane bending by protein–protein crowding

(2012) Jeanne C. Stachowiak et al.   NATURE CELL BIOLOGY

Assembly and disassembly of the ESCRT-III membrane scission complex

(2011) Manuel Alonso Y Adell et al.   FEBS LETTERS

A Role for the ESCRT System in Cell Division in Archaea

(2008) R. Y. Samson et al.   SCIENCE