Biomarker-activatable probes based on smart AIEgens for fluorescence and optoacoustic imaging

An Activatable Theranostic Nanoprobe for Dual-Modal Imaging-Guided Photodynamic Therapy with Self-Reporting of Sensitizer Activation and Therapeutic Effect

(2021) Zhongtao Zhang et al.   ACS Nano

Facilitation of molecular motion to develop turn-on photoacoustic bioprobe for detecting nitric oxide in encephalitis

(2021) Ji Qi et al.   Nature Communications

Hypoxia-activated Probe for NIR Fluorescence and Photoacoustic Dual-mode Tumor Imaging

(2021) Meng Li et al.   iScience

Tailoring Supramolecular Prodrug Nanoassemblies for Reactive Nitrogen Species-Potentiated Chemotherapy of Liver Cancer

(2021) Yongyan Deng et al.   ACS Nano

Fluorescent sensors: A bright future for cages

(2021) Anna Brzechwa-Chodzyńska et al.   COORDINATION CHEMISTRY REVIEWS

Optoacoustic imaging in endocrinology and metabolism

(2021) Angelos Karlas et al.   Nature Reviews Endocrinology

Hypoxia-Triggered In Situ Self-Assembly of a Charge Switchable Azo Polymer with AIEgens for Tumor Imaging

(2021) Jiajia Shen et al.   ACS Macro Letters

Designing Squaraine Dyes with Bright Deep‐Red Aggregation‐Induced Emission for Specific and Ratiometric Fluorescent Detection of Hypochlorite

(2021) Weiguo Qiao et al.   ADVANCED FUNCTIONAL MATERIALS

TEPP-46-Based AIE Fluorescent Probe for Detection and Bioimaging of PKM2 in Living Cells

(2021) Dong Wang et al.   ANALYTICAL CHEMISTRY

Biomarkers for neurodegenerative diseases

(2021) Oskar Hansson   NATURE MEDICINE

An NIR‐Fluorophore‐Based Theranostic for Selective Initiation of Tumor Pyroptosis‐Induced Immunotherapy

(2021) Kewei Wang et al.   Small

A Targeted Nanosystem for Detection of Inflammatory Diseases via Fluorescent/Optoacoustic Imaging and Therapy via Modulating Nrf2/NF‐κB Pathways

(2021) Juan Ouyang et al.   Small

Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations

(2021) Nicholas C. Cullen et al.   Nature Communications

An Activatable Probe with Aggregation‐Induced Emission for Detecting and Imaging Herbal Medicine Induced Liver Injury with Optoacoustic Imaging and NIR‐II Fluorescence Imaging

(2021) Lihe Sun et al.   Advanced Healthcare Materials

Insight into sulfur dioxide and its derivatives metabolism in living system with visualized evidences via ultra-sensitive fluorescent probe

(2021) Xia Zhang et al.   JOURNAL OF HAZARDOUS MATERIALS

Diketopyrrolopyrrole-based sensor for over-expressed peroxynitrite in drug-induced hepatotoxicity via ratiometric fluorescence imaging

(2021) Nannan Wang et al.   SENSORS AND ACTUATORS B-CHEMICAL

A H2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging

(2021) Junjie Chen et al.   Nature Communications

A novel fluorescent probe for the detection of peroxynitrite and its application in acute liver injury model

(2021) Chen Jin et al.   Redox Biology

A Glutathione Activatable Ion Channel Induces Apoptosis in Cancer Cells by Depleting Intracellular Glutathione Levels

(2020) Javid Ahmad Malla et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heat Stroke in Cell Tissues Related to Sulfur Dioxide Level Is Precisely Monitored by Light-Controlled Fluorescent Probes

(2020) Weijie Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Employing an ICT-FRET Integration Platform for the Real-Time Tracking of SO2 Metabolism in Cancer Cells and Tumor Models

(2020) Weijie Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-galactosidase responsive AIE fluorogene for identification and removal of senescent cancer cells

(2020) Zhengfeng Gao et al.   Science China-Chemistry

Fluorescent Imaging of Reactive Oxygen and Nitrogen Species Associated with Pathophysiological Processes

(2020) Ji-Ting Hou et al.   Chem

Reactive Oxygen Species Responsive Theranostic Nanoplatform for Two-Photon Aggregation-Induced Emission Imaging and Therapy of Acute and Chronic Inflammation

(2020) Boxuan Ma et al.   ACS Nano

Activatable fluorescent probe based on aggregation-induced emission for detecting hypoxia-related pathological conditions

(2020) Lingfeng Xu et al.   ANALYTICA CHIMICA ACTA

Detection of Bacterial Alkaline Phosphatase Activity by Enzymatic In Situ Self-Assembly of the AIEgen-Peptide Conjugate

(2020) Xue Zhang et al.   ANALYTICAL CHEMISTRY

Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

(2020) Yusheng Cai et al.   CELL RESEARCH

Sugar-Based Aggregation-Induced Emission Luminogens: Design, Structures, and Applications

(2020) Yijia Wang et al.   CHEMICAL REVIEWS

Recent advances in the development of responsive probes for selective detection of cysteine

(2020) Run Zhang et al.   COORDINATION CHEMISTRY REVIEWS

Role of hydrogen sulfide in endothelial dysfunction: Pathophysiology and therapeutic approaches

(2020) Valentina Citi et al.   Journal of Advanced Research

A novel AIEgen-based probe for detecting cysteine in lipid droplets

(2020) Wei Cheng et al.   ANALYTICA CHIMICA ACTA

Activatable Nanocomposite Probe for Preoperative Location and Intraoperative Navigation for Orthotopic Hepatic Tumor Resection via MSOT and Aggregation-Induced Near-IR-I/II Fluorescence Imaging

(2020) Zhuo Zeng et al.   ANALYTICAL CHEMISTRY

Single AIEgen for multiple tasks: Imaging of dual organelles and evaluation of cell viability

(2020) Ruoyao Zhang et al.   BIOMATERIALS

Recent advances in the development of NIR-II organic emitters for biomedicine

(2020) Jun Li et al.   COORDINATION CHEMISTRY REVIEWS

Aggregation Enhanced Responsiveness of Rationally Designed Probes to Hydrogen Sulfide for Targeted Cancer Imaging

(2020) Rongchen Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A facile AIEgen-based fluorescent probe design strategy and its application in hypochlorite probe construction

(2020) Chenggong Xu et al.   SENSORS AND ACTUATORS B-CHEMICAL

Lipid Droplet‐Targetable Fluorescence Guided Photodynamic Therapy of Cancer Cells with an Activatable AIE‐Active Fluorescent Probe for Hydrogen Peroxide

(2020) Guoyu Jiang et al.   Advanced Optical Materials

Nitric oxide in cellular adaptation and disease

(2020) Benjamin N. Gantner et al.   Redox Biology

HClO‐Activated Fluorescence and Photosensitization from an AIE Nanoprobe for Image‐Guided Bacterial Ablation in Phagocytes

(2020) Min Wu et al.   ADVANCED MATERIALS

Epithelial-Derived Reactive Oxygen Species Enable AppBCX-Mediated Aerobic Respiration of Escherichia coli during Intestinal Inflammation

(2020) Rachael B. Chanin et al.   Cell Host & Microbe

Ligand-Directed Approach to Activity-Based Sensing: Developing Palladacycle Fluorescent Probes That Enable Endogenous Carbon Monoxide Detection

(2020) Johannes Morstein et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A novel activatable AIEgen fluorescent probe for peroxynitrite detection and its application in EC1 cells

(2020) Xiaojing Han et al.   SENSORS AND ACTUATORS B-CHEMICAL

ROS Responsive Nanoplatform with Two‐Photon AIE Imaging for Atherosclerosis Diagnosis and “Two‐Pronged” Therapy

(2020) Boxuan Ma et al.   Small

A Simple Aggregation-Induced Emission Nanoprobe with Deep Tumor Penetration for Hypoxia Detection and Imaging-Guided Surgery in Vivo

(2020) Zhongtao Zhang et al.   ANALYTICAL CHEMISTRY

Molecular Chemiluminescent Probes with a Very Long Near‐Infrared Emission Wavelength for in Vivo Imaging

(2020) Jingsheng Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two-channel responsive luminescent chemosensors for dioxygen species: Molecular oxygen, singlet oxygen and superoxide anion

(2020) Zhen Zhang et al.   COORDINATION CHEMISTRY REVIEWS

Reactive oxygen species, thiols and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics

(2020) Jun Li et al.   COORDINATION CHEMISTRY REVIEWS

Metal-coordinated fluorescent and luminescent probes for reactive oxygen species (ROS) and reactive nitrogen species (RNS)

(2020) Nahyun Kwon et al.   COORDINATION CHEMISTRY REVIEWS

Small molecular fluorescent probes for the detection of lead, cadmium and mercury ions

(2020) Shan-Yong Chen et al.   COORDINATION CHEMISTRY REVIEWS

An easily available ratiometric AIE probe for peroxynitrite in vitro and in vivo imaging

(2020) Guoyu Jiang et al.   SENSORS AND ACTUATORS B-CHEMICAL

A Nanoprobe for Diagnosing and Mapping Lymphatic Metastasis of Tumor Using 3D Multispectral Optoacoustic Tomography Owing to Aggregation/Deaggregation Induced Spectral Change

(2019) Yinglong Wu et al.   ADVANCED FUNCTIONAL MATERIALS

Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing

(2019) Shangfeng Wang et al.   Nature Communications

Rapid volumetric optoacoustic imaging of neural dynamics across the mouse brain

(2019) Sven Gottschalk et al.   Nature Biomedical Engineering

Reactive Oxygen Species (ROS)-Based Nanomedicine

(2019) Bowen Yang et al.   CHEMICAL REVIEWS

Near-Infrared Aggregation-Induced Emission-Active Probe Enables in situ and Long-Term Tracking of Endogenous β-Galactosidase Activity

(2019) Wei Fu et al.   Frontiers in Chemistry

Recognition Moieties of Small Molecular Fluorescent Probes for Bioimaging of Enzymes

(2019) Xiaofeng Wu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Design Principles, Sensing Mechanisms, and Applications of Highly Specific Fluorescent Probes for HOCl/OCl–

(2019) Di Wu et al.   ACCOUNTS OF CHEMICAL RESEARCH

A New Strategy toward “Simple” Water-Soluble AIE Probes for Hypoxia Detection

(2019) Changhuo Xu et al.   ADVANCED FUNCTIONAL MATERIALS

An Easily Available Ratiometric Reaction-Based AIE Probe for Carbon Monoxide Light-up Imaging

(2019) Jianguo Wang et al.   ANALYTICAL CHEMISTRY

“Turn‐On” Activatable AIE Dots for Tumor Hypoxia Imaging

(2019) Tianhao Xue et al.   CHEMISTRY-A EUROPEAN JOURNAL

Reaction-Based Fluorescent Probes for the Detection and Imaging of Reactive Oxygen, Nitrogen, and Sulfur Species

(2019) Luling Wu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Aggregation-Induced Emission Luminogens for Activity-Based Sensing

(2019) Dong Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

An AIEgen-Peptide Conjugate as a Phototheranostic Agent for Phagosome-Entrapped Bacteria

(2019) Guobin Qi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Disease Detection with Molecular Biomarkers: From Chemistry of Body Fluids to Nature-Inspired Chemical Sensors

(2019) Yoav Y. Broza et al.   CHEMICAL REVIEWS

Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology

(2019) Masayuki Ide et al.   EMBO Molecular Medicine

A Förster Resonance Energy Transfer Switchable Fluorescent Probe With H2S-Activated Second Near-Infrared Emission for Bioimaging

(2019) Rongchen Wang et al.   Frontiers in Chemistry

Non-invasive in vivo imaging of caspase-1 activation enables rapid and spatiotemporal detection of acute and chronic inflammatory disorders

(2019) Young Ji Ko et al.   BIOMATERIALS

An Unsymmetrical Squaraine‐Based Activatable Probe for Imaging Lymphatic Metastasis by Responding to Tumor Hypoxia with MSOT and Aggregation‐Enhanced Fluorescent Imaging

(2019) Yi Lin et al.   CHEMISTRY-A EUROPEAN JOURNAL

Detection of collagens by multispectral optoacoustic tomography as an imaging biomarker for Duchenne muscular dystrophy

(2019) Adrian P. Regensburger et al.   NATURE MEDICINE

Repurposing Cyanine NIR-I Dyes Accelerates Clinical Translation of Near-Infrared-II (NIR-II) Bioimaging

(2018) Shoujun Zhu et al.   ADVANCED MATERIALS

Recent development of technology and application of photoacoustic molecular imaging toward clinical translation

(2018) Jaesok Yu et al.   JOURNAL OF NUCLEAR MEDICINE

A Visible and Near-Infrared, Dual-Channel Fluorescence-On Probe for Selectively Tracking Mitochondrial Glutathione

(2018) Zhiqiang Xu et al.   Chem

New Diketopyrrolopyrrole-Based Ratiometric Fluorescent Probe for Intracellular Esterase Detection and Discrimination of Live and Dead Cells in Different Fluorescence Channels

(2018) Jian Wang et al.   ACS Applied Materials & Interfaces

Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo

(2018) Yuanyuan Fu et al.   Autophagy

Hypoxia and thrombosis

(2018) Josef T. Prchal   BLOOD

Evolution of Hydrogen Sulfide Therapeutics to Treat Cardiovascular Disease

(2018) Zhen Li et al.   CIRCULATION RESEARCH

Endothelial pyruvate kinase M2 maintains vascular integrity

(2018) Boa Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Activatable probes for diagnosing and positioning liver injury and metastatic tumors by multispectral optoacoustic tomography

(2018) Yinglong Wu et al.   Nature Communications

Programmable Chemotherapy and Immunotherapy against Breast Cancer Guided by Multiplexed Fluorescence Imaging in the Second Near-Infrared Window

(2018) Xiaoxia Hao et al.   ADVANCED MATERIALS

A Fluorescent Probe with Aggregation-Induced Emission for Detecting Alkaline Phosphatase and Cell Imaging

(2018) Mingang Lin et al.   Chemistry-An Asian Journal

Responsive Upconversion Nanoprobe for Background‐Free Hypochlorous Acid Detection and Bioimaging

(2018) Run Zhang et al.   Small

Upconversion Nanoprobes for the Ratiometric Luminescent Sensing of Nitric Oxide

(2017) Ningning Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photostable Ratiometric Pdot Probe for in Vitro and in Vivo Imaging of Hypochlorous Acid

(2017) Li Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dual-Site Fluorescent Probe for Visualizing the Metabolism of Cys in Living Cells

(2017) Yongkang Yue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alkaline phosphatase: a novel treatment target for cardiovascular disease in CKD

(2017) Mathias Haarhaus et al.   Nature Reviews Nephrology

In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe

(2017) Xinyuan He et al.   Chemical Science

A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B

(2017) N. Pengo et al.   Nature Communications

Quantitative real-time imaging of glutathione

(2017) Xiqian Jiang et al.   Nature Communications

Esterase-Activated Charge-Reversal Polymer for Fibroblast-Exempt Cancer Gene Therapy

(2016) Nasha Qiu et al.   ADVANCED MATERIALS

Esterase-Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide

(2016) Yueqin Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer

(2016) S R Rao et al.   BRITISH JOURNAL OF CANCER

Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System

(2016) Kathy K. Griendling et al.   CIRCULATION RESEARCH

pH-Controlled Hydrogen Sulfide Release for Myocardial Ischemia-Reperfusion Injury

(2016) Jianming Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Real-Time Tracking and In Vivo Visualization of β-Galactosidase Activity in Colorectal Tumor with a Ratiometric Near-Infrared Fluorescent Probe

(2016) Kaizhi Gu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent Structural Insights into Cytochrome P450 Function

(2016) F. Peter Guengerich et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Deoxynyboquinones as NQO1-Activated Cancer Therapeutics

(2015) Elizabeth I. Parkinson et al.   ACCOUNTS OF CHEMICAL RESEARCH

Aggregation-Induced Emission: Together We Shine, United We Soar!

(2015) Ju Mei et al.   CHEMICAL REVIEWS

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

A small-molecule dye for NIR-II imaging

(2015) Alexander L. Antaris et al.   NATURE MATERIALS

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Advances in real-time multispectral optoacoustic imaging and its applications

(2015) Adrian Taruttis et al.   Nature Photonics

Nitric oxide in liver diseases

(2015) Yasuko Iwakiri et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Assessment of Hypoxia in the Stroma of Patient-Derived Pancreatic Tumor Xenografts

(2014) Ines Lohse et al.   Cancers

Regulation and function of pyruvate kinase M2 in cancer

(2013) Weiwei Yang et al.   CANCER LETTERS

Stromal cells in tumor microenvironment and breast cancer

(2012) Yan Mao et al.   CANCER AND METASTASIS REVIEWS

Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells

(2012) M. Tamada et al.   CLINICAL CANCER RESEARCH

Biomarkers in the Clinical Diagnosis and Management of Traumatic Brain Injury

(2012) Georgene W. Hergenroeder et al.   Molecular Diagnosis & Therapy

SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions

(2012) K. E. Keller et al.   SCIENCE

Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer

(2011) Q. Chang et al.   CANCER RESEARCH

Chemistry and biology of reactive oxygen species in signaling or stress responses

(2011) Bryan C Dickinson et al.   Nature Chemical Biology

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytochrome P450 enzymes in the brain: emerging evidence of biological significance

(2011) Charmaine S. Ferguson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Vasodilator effect of gaseous sulfur dioxide and regulation of its level by Ach in rat vascular tissues

(2009) Ziqiang Meng et al.   INHALATION TOXICOLOGY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY