Journal
REDOX BIOLOGY
Volume 34, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.redox.2020.101550
Keywords
Nitic oxide synthase; Adaptation; Intracellular signaling; Intercellular signaling
Categories
Funding
- Dr. Nancy Laning Sobczak Fund for Breast Cancer
- MCW Cancer Center through the Research and Education Program Fund, a component of the Advancing a Healthier Wisconsin endowment
- MCW Research Affairs Committee [RO1CA216882, RO1AI131267, RO1ES028149]
- DOD [71138LS]
- Wisconsin Breast Cancer Showhouse
Ask authors/readers for more resources
Nitric oxide synthases are the major sources of nitric oxide, a critical signaling molecule involved in a wide range of cellular and physiological processes. These enzymes comprise a family of genes that are highly conserved across all eukaryotes. The three family members found in mammals are important for inter- and intra-cellular signaling in tissues that include the nervous system, the vasculature, the gut, skeletal muscle, and the immune system, among others. We summarize major advances in the understanding of biochemical and tissue -speci fic roles of nitric oxide synthases, with a focus on how these mechanisms enable tissue adaptation and health or dysfunction and disease. We highlight the unique mechanisms and processes of neuronal nitric oxide synthase, or NOS1. This was the first of these enzymes discovered in mammals, and yet much remains to be understood about this highly conserved and complex gene. We provide examples of two areas that will likely be of increasing importance in nitric oxide biology. These include the mechanisms by which these critical enzymes promote adaptation or disease by 1) coordinating communication by diverse cell types within a tissue and 2) directing cellular di fferentiation/activation decisions processes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available