Altersolanol B, a fungal tetrahydroanthraquinone, inhibits the proliferation of estrogen receptor-expressing (ER+) human breast adenocarcinoma by modulating PI3K/AKT, p38/ERK MAPK and associated signaling pathways

Understanding MAPK Signaling Pathways in Apoptosis

(2020) Jicheng Yue et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bioactivities and Structure–Activity Relationships of Natural Tetrahydroanthraquinone Compounds: A Review

(2020) Shixiu Feng et al.   Frontiers in Pharmacology

Targeting GSK3 and Associated Signaling Pathways Involved in Cancer

(2020) Przemysław Duda et al.   Cells

Epicatechin and scopoletin rich Morinda citrifolia (Noni) leaf extract supplementation, mitigated Osteoarthritis via anti-inflammatory, anti-oxidative, and anti-protease pathways

(2019) Wan NurFarahin Wan Osman et al.   JOURNAL OF FOOD BIOCHEMISTRY

Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer

(2019) Alexandria C. Rutkovsky et al.   BMC CANCER

AKT and ERK dual inhibitors: The way forward?

(2019) Zhe Cao et al.   CANCER LETTERS

Epicatechin and scopoletin‐rich Morinda citrifolia leaf ameliorated leukemia via anti‐inflammatory, anti‐angiogenesis, and apoptosis pathways in vitro and in vivo

(2019) Negin Ahmadi et al.   JOURNAL OF FOOD BIOCHEMISTRY

Use of Complementary and Alternative Medicine among Young Patients with Breast Cancer

(2019) Friederike Hammersen et al.   Breast Care

Properties and Applications of Morinda citrifolia (Noni): A Review

(2019) Édipo S. Almeida et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

DPS-2: A Novel Dual MEK/ERK and PI3K/AKT Pathway Inhibitor with Powerful Ex Vivo and In Vivo Anticancer Properties

(2019) Maria Goulielmaki et al.   Translational Oncology

BCL-2 proteins and apoptosis: Recent insights and unknowns

(2018) Frank Edlich   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of apoptosis by pyrazolo[3,4- d ]pyridazine derivative in lung cancer cells via disruption of Bcl-2 / Bax expression balance

(2018) Mervat S. Mohamed et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Advances in the Discovery of Anthraquinone-Based Anticancer Agents

(2018) Alexander S. Tikhomirov et al.   Recent Patents on Anti-Cancer Drug Discovery

A real-time, bioluminescent annexin V assay for the assessment of apoptosis

(2018) Kevin Kupcho et al.   APOPTOSIS

A phase Ib dose-escalation and expansion study of the oral MEK inhibitor pimasertib and PI3K/MTOR inhibitor voxtalisib in patients with advanced solid tumours

(2018) Alison M. Schram et al.   BRITISH JOURNAL OF CANCER

A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer

(2017) Zev A. Wainberg et al.   Targeted Oncology

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity—Diverse effects on cell growth, metabolism and cancer

(2016) James A. McCubrey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Use of complementary and alternative medicine and breast cancer survival in the Health, Eating, Activity, and Lifestyle Study

(2016) Marian L. Neuhouser et al.   BREAST CANCER RESEARCH AND TREATMENT

4E-BP1, a multifactor regulated multifunctional protein

(2016) Xiaoyu Qin et al.   CELL CYCLE

New cytotoxic compounds of endophytic fungus Alternaria sp. isolated from Broussonetia papyrifera (L.) Vent

(2016) Naidan Zhang et al.   FITOTERAPIA

A randomized phase II non-comparative study of PF-04691502 and gedatolisib (PF-05212384) in patients with recurrent endometrial cancer

(2016) Josep María del Campo et al.   GYNECOLOGIC ONCOLOGY

Cell-in-Cell Death Is Not Restricted by Caspase-3 Deficiency in MCF-7 Cells

(2016) Shan Wang et al.   Journal of Breast Cancer

Antibacterial Constituents of HainanMorinda citrifolia(Noni) Leaves

(2016) Wei-Min Zhang et al.   JOURNAL OF FOOD SCIENCE

Anthraquinones As Pharmacological Tools and Drugs

(2016) Enas M. Malik et al.   MEDICINAL RESEARCH REVIEWS

Metastasized lung cancer suppression by Morinda citrifolia (Noni) leaf compared to Erlotinib via anti-inflammatory, endogenous antioxidant responses and apoptotic gene activation

(2016) Swee-Ling Lim et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin against Human Breast Cancer MCF-7 Cells in Vitro

(2016) Muhammad Aziz et al.   MOLECULES

Juglanthraquinone C Induces Intracellular ROS Increase and Apoptosis by Activating the Akt/Foxo Signal Pathway in HCC Cells

(2016) Ya-Qin Hou et al.   Oxidative Medicine and Cellular Longevity

A Friendly Relationship between Endophytic Fungi and Medicinal Plants: A Systematic Review

(2016) Min Jia et al.   Frontiers in Microbiology

Tetrahydroanthraquinone Derivative (±)-4-Deoxyaustrocortilutein Induces Cell Cycle Arrest and Apoptosis in Melanoma Cells via Upregulation of p21 and p53 and Downregulation of NF-kappaB

(2016) Miroslav Genov et al.   Journal of Cancer

The Roles of p38 MAPK and ERK1/2 in Coplanar Polychlorinated Biphenyls-Induced Apoptosis of Human Extravillous Cytotrophoblast-Derived Transformed Cells

(2015) Zhu Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Metabolites from Combretum dolichopetalum and its associated endophytic fungus Nigrospora oryzae — Evidence for a metabolic partnership

(2015) Philip F. Uzor et al.   FITOTERAPIA

The Marine Metabolite SZ-685C Induces Apoptosis in Primary Human Nonfunctioning Pituitary Adenoma Cells by Inhibition of the Akt Pathway in Vitro

(2015) Xin Wang et al.   Marine Drugs

Cambogin Induces Caspase-Independent Apoptosis through the ROS/JNK Pathway and Epigenetic Regulation in Breast Cancer Cells

(2015) K. Shen et al.   MOLECULAR CANCER THERAPEUTICS

Secondary Metabolites from Rubiaceae Species

(2015) Daiane Martins et al.   MOLECULES

Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: The involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway

(2014) GUK HEUI JO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

US Incidence of Breast Cancer Subtypes Defined by Joint Hormone Receptor and HER2 Status

(2014) Nadia Howlader et al.   JNCI-Journal of the National Cancer Institute

Antiviral activity of extracts fromMorinda citrifolialeaves and chlorophyll catabolites, pheophorbide a and pyropheophorbide a, against hepatitis C virus

(2014) Suratno Lulut Ratnoglik et al.   MICROBIOLOGY AND IMMUNOLOGY

Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion

(2014) Kazumasa Ohashi et al.   MOLECULAR BIOLOGY OF THE CELL

ROS-Dependent Antiproliferative Effect of Brassinin Derivative Homobrassinin in Human Colorectal Cancer Caco2 Cells

(2014) Martin Kello et al.   MOLECULES

Activation of JNK Contributes to Evodiamine-Induced Apoptosis and G2/M Arrest in Human Colorectal Carcinoma Cells: A Structure-Activity Study of Evodiamine

(2014) Chih-Chiang Chien et al.   PLoS One

Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells

(2014) MUHAMMAD YUSRAN ABDUL AZIZ et al.   Oncology Letters

Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity

(2013) Marie-Hélène Teiten et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Optimal Binary Solvent Extraction System for Phenolic Antioxidants from Mengkudu (Morinda citrifolia) Fruit

(2013) Yin Thoo et al.   MOLECULES

Antiangiogenetic effects of anthranoids from Alternaria sp., an endophytic fungus in a Thai medicinal plant Erythrina variegata

(2013) Phunlap Pompeng et al.   PHYTOMEDICINE

OpenCFU, a New Free and Open-Source Software to Count Cell Colonies and Other Circular Objects

(2013) Quentin Geissmann   PLoS One

Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects

(2013) J. E. Allen et al.   Science Translational Medicine

Regulation of the Intrinsic Apoptosis Pathway by Reactive Oxygen Species

(2012) Chu-Chiao Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

The lipopeptide toxins anabaenolysin A and B target biological membranes in a cholesterol-dependent manner

(2012) Linn Oftedal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cancer Therapy–Induced Cardiac Toxicity in Early Breast Cancer

(2012) Michel G. Khouri et al.   CIRCULATION

Reactive Oxygen Species in Health and Disease

(2012) Assim A. Alfadda et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids

(2012) P Newsholme et al.   JOURNAL OF ENDOCRINOLOGY

A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling

(2012) Xun Zhu et al.   Marine Drugs

Anthraquinone derivatives from the mangrove-derived fungus Phomopsis sp. PSU-MA214

(2012) Saranyoo Klaiklay et al.   Phytochemistry Letters

Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways

(2012) Xue-mei Chen et al.   TOXICOLOGY IN VITRO

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

(2011) Ganta Chaitanya et al.   Cell Communication and Signaling

Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects

(2011) Lishuang Lv et al.   FITOTERAPIA

PI3K: A potential therapeutic target for cancer

(2011) Yingwei Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Damnacanthal, a noni component, exhibits antitumorigenic activity in human colorectal cancer cells

(2011) Thararat Nualsanit et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

GSK-3: Functional Insights from Cell Biology and Animal Models

(2011) Oksana Kaidanovich-Beilin et al.   Frontiers in Molecular Neuroscience

Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation

(2010) Irina F. Sevrioukova   ANTIOXIDANTS & REDOX SIGNALING

Instability of, and generation of hydrogen peroxide by, phenolic compounds in cell culture media

(2010) Lee Hua Long et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

SZ-685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway

(2010) Gui'e Xie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Multiple Berry Types Prevent N-nitrosomethylbenzylamine-Induced Esophageal Cancer in Rats

(2010) Gary D. Stoner et al.   PHARMACEUTICAL RESEARCH

Wound healing effects of noni (Morinda citrifolia L.) leaves: a mechanism involving its PDGF/A2A receptor ligand binding and promotion of wound closure

(2010) Afa Palu et al.   PHYTOTHERAPY RESEARCH

Isolation, Purification, and Biological Activity of a Phytotoxin Produced by Stemphylium solani

(2010) Lu Zheng et al.   PLANT DISEASE

N-Tosyl-l-phenylalanine Chloromethyl Ketone Inhibits NF-κB Activation by Blocking Specific Cysteine Residues of IκB Kinase β and p65/RelA

(2009) Kyung-Ho Ha et al.   BIOCHEMISTRY

Apoptosis-inducing effects ofMorinda citrifoliaL. and doxorubicin on the Ehrlich ascites tumor in Balb-c mice

(2009) Elif İlkay Taşkın et al.   CELL BIOCHEMISTRY AND FUNCTION

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

New anthraquinone glycosides from the roots of Morinda citrifolia

(2009) Kohei Kamiya et al.   FITOTERAPIA

Bioactive Metabolites from the Endophytic FungusStemphylium globuliferumIsolated fromMentha pulegium

(2009) Abdessamad Debbab et al.   JOURNAL OF NATURAL PRODUCTS

A new anthraquinone fromMorinda citrifoliaroots

(2009) G.C.L. Ee et al.   NATURAL PRODUCT RESEARCH

Tumour cell survival signalling by the ERK1/2 pathway

(2008) K Balmanno et al.   CELL DEATH AND DIFFERENTIATION

Deregulation of the Akt Pathway in Human Cancer

(2008) Eriko Tokunaga et al.   CURRENT CANCER DRUG TARGETS

Bioactive metabolites from the endophytic fungus Ampelomyces sp. isolated from the medicinal plant Urospermum picroides

(2008) Amal H. Aly et al.   PHYTOCHEMISTRY