Anthraquinones As Pharmacological Tools and Drugs

Ullmann reactions of 1-amino-4-bromoanthraquinones bearing various 2-substituents furnishing novel dyes

(2016) Enas M. Malik et al.   DYES AND PIGMENTS

Syntheses of 2-substituted 1-amino-4-bromoanthraquinones (bromaminic acid analogues) – precursors for dyes and drugs

(2015) Enas M Malik et al.   Beilstein Journal of Organic Chemistry

Medicinal Chemistry of P2X Receptors: Allosteric Modulators

(2015) Christa Muller   CURRENT MEDICINAL CHEMISTRY

A fruitful decade from 2005 to 2014 for anthraquinone patents

(2015) Hidayat Hussain et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A mode of action study of cationic anthraquinone analogs: a new class of highly potent anticancer agents

(2015) Jaya P. Shrestha et al.   MedChemComm

Rhein prevents endotoxin-induced acute kidney injury by inhibiting NF-κB activities

(2015) Chen Yu et al.   Scientific Reports

Synthesis and anticancer structure activity relationship investigation of cationic anthraquinone analogs

(2014) Jaya P. Shrestha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels

(2014) Subhrangsu Roy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anthraquinones, the Dr Jekyll and Mr Hyde of the food pigment family

(2014) Laurent Dufossé   FOOD RESEARCH INTERNATIONAL

Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071

(2014) Matthias Zebisch et al.   JOURNAL OF STRUCTURAL BIOLOGY

Prevention of Anthracycline-Induced Cardiotoxicity

(2014) Pimprapa Vejpongsa et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Fungal anthraquinones

(2013) N. N. Gessler et al.   APPLIED BIOCHEMISTRY AND MICROBIOLOGY

Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors

(2013) Bilel Jelassi et al.   CARCINOGENESIS

On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs

(2013) Chyuan-Chuan Wu et al.   NUCLEIC ACIDS RESEARCH

Protein-Protein Interactions as a Strategy towards Protein-Specific Drug Design: The Example of Ataxin-1

(2013) Cesira de Chiara et al.   PLoS One

Genotoxicological assessment of two reactive dyes extracted from cotton fibres using artificial sweat

(2013) Daniela Morais Leme et al.   TOXICOLOGY IN VITRO

Anthraquinone-2-sulfonic acid (AQ2S) is A Novel Neurotherapeutic Agent

(2013) T C Jackson et al.   Cell Death & Disease

Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway

(2013) Zhongjie Liang et al.   ACS Medicinal Chemistry Letters

Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: Roles of apoptotic cell death and LS1034 tumor xenografts model

(2012) Yi-Shih Ma et al.   FOOD AND CHEMICAL TOXICOLOGY

Chrysophanol-8-O-glucoside, an Anthraquinone Derivative in Rhubarb, Has Antiplatelet and Anticoagulant Activities

(2012) Eun Ji Seo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

(2012) Oktay Tacar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Adriamycin dose and time effects on cell cycle, cell death, and reactive oxygen species generation in leukaemia cells

(2012) Julien Savatier et al.   LEUKEMIA RESEARCH

Convergent Synthesis of the Potent P2Y Receptor Antagonist MG 50-3-1 Based on a Regioselective Ullmann Coupling Reaction

(2012) Younis Baqi et al.   MOLECULES

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Antitumor Activity of Emodin against Pancreatic Cancer Depends on Its Dual Role: Promotion of Apoptosis and Suppression of Angiogenesis

(2012) Sheng-Zhang Lin et al.   PLoS One

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Purification and Characterization of Hemagglutinating Proteins from Poker-Chip Venus (Meretrix lusoria) and Corbicula Clam (Corbicula fluminea)

(2012) Chin-Fu Cheng et al.   TheScientificWorldJOURNAL

Library Synthesis and Antibacterial Investigation of Cationic Anthraquinone Analogs

(2012) Marina Y. Fosso et al.   ACS Combinatorial Science

Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase. Implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells

(2011) Dorota Kostrzewa-Nowak et al.   ANTI-CANCER DRUGS

Mechanisms and management of doxorubicin cardiotoxicity

(2011) Y. Shi et al.   HERZ

Discovery of Potent Competitive Antagonists and Positive Modulators of the P2X2 Receptor

(2011) Younis Baqi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chronic Constipation: An Evidence-Based Review

(2011) L. Leung et al.   Journal of the American Board of Family Medicine

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Acid/base and hydrogen bonding effects on the proton-coupled electron transfer of quinones and hydroquinones in acetonitrile: Mechanistic investigation by voltammetry, 1H NMR and computation

(2010) Timothy M. Alligrant et al.   ELECTROCHIMICA ACTA

Studies on quinones. Part 46. Synthesis and in vitro antitumor evaluation of aminopyrimidoisoquinolinequinones

(2010) David Vásquez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of quinonoid compounds against tumor cell lines

(2010) Eufrânio N. da Silva et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Aloe-induced Toxic Hepatitis

(2010) Ha Na Yang et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Development of Potent and Selective Inhibitors ofecto-5′-Nucleotidase Based on an Anthraquinone Scaffold

(2010) Younis Baqi et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Limitations in doxorubicin production from Streptomyces peucetius

(2010) Sailesh Malla et al.   MICROBIOLOGICAL RESEARCH

Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects

(2010)   MOVEMENT DISORDERS

Cardiotoxicity and other adverse events associated with mitoxantrone treatment for MS

(2010) E. Kingwell et al.   NEUROLOGY

Effects of diacerein at the molecular level in the osteoarthritis disease process

(2010) Johanne Martel-Pelletier et al.   Therapeutic Advances in Musculoskeletal Disease

Reversible redox chemistry of quinones: Impact on biogeochemical cycles

(2009) Minori Uchimiya et al.   CHEMOSPHERE

High-Affinity, Non-Nucleotide-Derived Competitive Antagonists of Platelet P2Y12Receptors

(2009) Younis Baqi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding

(2009) Kristin E. D. Coan et al.   JOURNAL OF MEDICINAL CHEMISTRY

A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase

(2009) Adam Yasgar et al.   Molecular BioSystems

Aloe-emodin-induced DNA fragmentation in the mouse in vivo comet assay

(2009) Fabrice Nesslany et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Antiplatelet Effect and Selective Binding to Cyclooxygenase by Molecular Docking Analysis of 3-Alkylaminopropoxy-9,10-anthraquinone Derivatives

(2008) Kim-Hong Gan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Identification of Chemical Inhibitors to Human Tissue Transglutaminase by Screening Existing Drug Libraries

(2008) Thung-S. Lai et al.   CHEMISTRY & BIOLOGY

Dexrazoxane (TotectTM): FDA Review and Approval for the Treatment of Accidental Extravasation Following Intravenous Anthracycline Chemotherapy

(2008) R. C. Kane et al.   ONCOLOGIST

Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases)

(2008) Younis Baqi et al.   Purinergic Signalling

Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists

(2007) Stefanie Weyler et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effects of KP-496, a novel dual antagonist at the cysteinyl leukotriene receptor 1 and the thromboxane A2receptor, on airway obstruction in guinea pigs

(2007) M Ishimura et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of solution pH, ionic strength, and temperature on adsorption behavior of reactive dyes on activated carbon

(2007) Y ALDEGS et al.   DYES AND PIGMENTS

Transport of sennosides and sennidines from Cassia angustifolia and Cassia senna across Caco-2 monolayers – an in vitro model for intestinal absorption

(2007) B. Waltenberger et al.   PHYTOMEDICINE