Structural mechanism of TRPM7 channel regulation by intracellular magnesium

Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition

(2021) Zheng Ruan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics

(2021) Astrid Kollewe et al.   eLife

Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

(2019) Ying Yin et al.   SCIENCE

TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival

(2019) Lorenz Mittermeier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Structural insights into TRPM8 inhibition and desensitization

(2019) Melinda M. Diver et al.   SCIENCE

Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel

(2019) Yihe Huang et al.   eLife

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Role of kinase-coupled TRP channels in mineral homeostasis

(2018) Vladimir Chubanov et al.   PHARMACOLOGY & THERAPEUTICS

Structure of full-length human TRPM4

(2018) Jingjing Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

(2018) Zhe Zhang et al.   eLife

Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium

(2018) Yihe Huang et al.   NATURE

Structure of the mammalian TRPM7, a magnesium channel required during embryonic development

(2018) Jingjing Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TRPM7 channel kinase regulates store-operated calcium entry

(2017) Malika Faouzi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structures of the calcium-activated, non-selective cation channel TRPM4

(2017) Jiangtao Guo et al.   NATURE

Electron cryo-microscopy structure of a human TRPM4 channel

(2017) Paige A. Winkler et al.   NATURE

Opening of the human epithelial calcium channel TRPV6

(2017) Luke L. McGoldrick et al.   NATURE

TRPM7 senses oxidative stress to release Zn2+from unique intracellular vesicles

(2017) Sunday A. Abiria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the human TRPM4 ion channel in a lipid nanodisc

(2017) Henriette E. Autzen et al.   SCIENCE

All atom NMDA receptor transmembrane domain model development and simulations in lipid bilayers and water

(2017) Samaneh Mesbahi-Vasey et al.   PLoS One

TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP

(2017) Silvia Ferioli et al.   Scientific Reports

TRPM7 is a molecular substrate of ATP-evoked P2X7-like currents in tumor cells

(2016) Wolfgang Nörenberg et al.   JOURNAL OF GENERAL PHYSIOLOGY

The coiled-coil domain of zebrafish TRPM7 regulates Mg·nucleotide sensitivity

(2016) Chad Jansen et al.   Scientific Reports

Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

(2016) Vladimir Chubanov et al.   eLife

Regulation of the transient receptor potential channel TRPM3 by phosphoinositides

(2015) Balázs I. Tóth et al.   JOURNAL OF GENERAL PHYSIOLOGY

Lipid14: The Amber Lipid Force Field

(2014) Callum J. Dickson et al.   Journal of Chemical Theory and Computation

Activation of TRPM7 channels by small molecules under physiological conditions

(2014) T. Hofmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Inactivation of TRPM7 kinase activity does not impair its channel function in mice

(2014) Taku Kaitsuka et al.   Scientific Reports

Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice

(2014) Lillia V. Ryazanova et al.   Scientific Reports

The structure and regulation of magnesium selective ion channels

(2013) Jian Payandeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

(2013) Daniel R. Roe et al.   Journal of Chemical Theory and Computation

Sensitivity of TRPM7 channels to Mg2+ characterized in cell-free patches of Jurkat T lymphocytes

(2012) Rikki Chokshi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Natural and synthetic modulators of SK (Kca2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7

(2012) V Chubanov et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cellular magnesium homeostasis

(2011) Andrea M.P. Romani   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Phosphatidylinositol 4,5-bisphosphate (PIP2) controls magnesium gatekeeper TRPM6 activity

(2011) Jia Xie et al.   Scientific Reports

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

TRPM7 is essential for Mg2+ homeostasis in mammals

(2010) Lillia V. Ryazanova et al.   Nature Communications

Evolutionary determinants of divergent calcium selectivity of TRPM channels

(2007) Michael Mederos y Schnitzler et al.   FASEB JOURNAL