Insights into the identification of a molecular signature for amyotrophic lateral sclerosis exploiting integrated microRNA profiling of iPSC-derived motor neurons and exosomes

TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS

(2021) Xinxin Zuo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Emerging role of microRNAs in the pathogenesis of amyotrophic lateral sclerosis

(2021) Nader Akbari Dilmaghani et al.   METABOLIC BRAIN DISEASE

Gene therapy for ALS: A review

(2021) Defne A. Amado et al.   MOLECULAR THERAPY

RNA Deregulation in Amyotrophic Lateral Sclerosis: The Noncoding Perspective

(2021) Pietro Laneve et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future

(2020) Heike J. Wobst et al.   MEDICINAL RESEARCH REVIEWS

Connecting RNA-Modifying Similarities of TDP-43, FUS, and SOD1 with MicroRNA Dysregulation Amidst A Renewed Network Perspective of Amyotrophic Lateral Sclerosis Proteinopathy

(2020) Jade Pham et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Disease-modifying therapies in amyotrophic lateral sclerosis

(2020) Adriano Chiò et al.   NEUROPHARMACOLOGY

miR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosis

(2020) Alessia Loffreda et al.   PROGRESS IN NEUROBIOLOGY

Cytoplasmic TDP43 Binds microRNAs: New Disease Targets in Amyotrophic Lateral Sclerosis

(2020) Ximena Paez-Colasante et al.   Frontiers in Cellular Neuroscience

Downregulation of miR-335-5P in Amyotrophic Lateral Sclerosis Can Contribute to Neuronal Mitochondrial Dysfunction and Apoptosis

(2020) Noemi De Luna et al.   Scientific Reports

Circulating Exosomal miRNA as Diagnostic Biomarkers of Neurodegenerative Diseases

(2020) Lin Wang et al.   Frontiers in Molecular Neuroscience

Amyotrophic lateral sclerosis: a clinical review

(2020) P. Masrori et al.   EUROPEAN JOURNAL OF NEUROLOGY

MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases

(2020) Mariano Catanesi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNAs as regulators of cell death mechanisms in amyotrophic lateral sclerosis

(2019) Delia Gagliardi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

RNA Dysregulation in Amyotrophic Lateral Sclerosis

(2019) Zoe Butti et al.   Frontiers in Genetics

An Overview of MicroRNAs as Biomarkers of ALS

(2019) Greig Joilin et al.   Frontiers in Neurology

TRPM2 Channel in Microglia as a New Player in Neuroinflammation Associated With a Spectrum of Central Nervous System Pathologies

(2019) Philippa Malko et al.   Frontiers in Pharmacology

Long non-coding RNA-p21 regulates MPP+-induced neuronal injury by targeting miR-625 and derepressing TRPM2 in SH-SY5Y cells

(2019) Xiu-Ming Ding et al.   CHEMICO-BIOLOGICAL INTERACTIONS

microRNA dysregulation in neurodegenerative diseases: A systematic review

(2019) Camille A. Juźwik et al.   PROGRESS IN NEUROBIOLOGY

Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies

(2019) Xiangyi Kong et al.   Frontiers in Oncology

Emerging roles of extracellular vesicles in neurodegenerative disorders

(2019) Yang You et al.   NEUROBIOLOGY OF DISEASE

Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS

(2018) Anika M. Helferich et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

FUS Regulates Activity of MicroRNA-Mediated Gene Silencing

(2018) Tao Zhang et al.   MOLECULAR CELL

A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons

(2018) Davide Capauto et al.   MOLECULAR NEUROBIOLOGY

Differential expression of microRNAs and other small RNAs in muscle tissue of patients with ALS and healthy age-matched controls

(2018) Anja Kovanda et al.   Scientific Reports

Small RNA Sequencing of Sporadic Amyotrophic Lateral Sclerosis Cerebrospinal Fluid Reveals Differentially Expressed miRNAs Related to Neural and Glial Activity

(2018) Rachel Waller et al.   Frontiers in Neuroscience

MicroRNA expression analysis identifies a subset of downregulated miRNAs in ALS motor neuron progenitors

(2018) Mafalda Rizzuti et al.   Scientific Reports

Wide-Ranging Analysis of MicroRNA Profiles in Sporadic Amyotrophic Lateral Sclerosis Using Next-Generation Sequencing

(2018) Bruna De Felice et al.   Frontiers in Genetics

The Role of MicroRNAs in Patients with Amyotrophic Lateral Sclerosis

(2018) Efthimios Dardiotis et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

MicroRNAs as Biomarkers in Amyotrophic Lateral Sclerosis

(2018) Claudia Ricci et al.   Cells

Exosomes: From Garbage Bins to Promising Therapeutic Targets

(2017) Mohammed H. Rashed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Screening the expression characteristics of several miRNAs in G93A-SOD1 transgenic mouse: altered expression of miRNA-124 is associated with astrocyte differentiation by targeting Sox2 and Sox9

(2017) Fenghua Zhou et al.   JOURNAL OF NEUROCHEMISTRY

MicroRNA Metabolism and Dysregulation in Amyotrophic Lateral Sclerosis

(2017) Paola Rinchetti et al.   MOLECULAR NEUROBIOLOGY

MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity

(2017) F. Capitano et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extracellular vesicle-packaged miRNA release after short-term exposure to particulate matter is associated with increased coagulation

(2017) Laura Pergoli et al.   Particle and Fibre Toxicology

Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases

(2017) Kira S. Sheinerman et al.   Alzheimers Research & Therapy

Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms

(2016) Claudia Figueroa-Romero et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Identification of miRNAs as Potential Biomarkers in Cerebrospinal Fluid from Amyotrophic Lateral Sclerosis Patients

(2016) Michele Benigni et al.   NEUROMOLECULAR MEDICINE

Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS

(2016) Ilary Allodi et al.   Scientific Reports

Therapeutic Development in Amyotrophic Lateral Sclerosis

(2015) Monica Bucchia et al.   CLINICAL THERAPEUTICS

MicroRNAs: Newcomers into the ALS Picture

(2015) Cinzia Volonte et al.   CNS & Neurological Disorders-Drug Targets

Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS

(2015) A. Emde et al.   EMBO JOURNAL

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

MicroRNAs as Potential Circulating Biomarkers for Amyotrophic Lateral Sclerosis

(2014) Frank Cloutier et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes

(2014) Yves Maury et al.   NATURE BIOTECHNOLOGY

miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients

(2014) Bruna De Felice et al.   NEUROGENETICS

An ALS-associated mutation in the FUS 3′-UTR disrupts a microRNA–FUS regulatory circuitry

(2014) Stefano Dini Modigliani et al.   Nature Communications

miRNAs in development and pathogenesis of the nervous system: Table 1

(2013) Jakub S. Nowak et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Altered microRNA expression profile in amyotrophic lateral sclerosis: a role in the regulation of NFL mRNA levels

(2013) Danae Campos-Melo et al.   Molecular Brain

MicroRNAs as biomarkers for CNS disease

(2013) Pooja Rao et al.   Frontiers in Molecular Neuroscience

Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis

(2013) Axel Freischmidt et al.   Acta Neuropathologica Communications

A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis

(2012) Bruna De Felice et al.   GENE

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis

(2012) Claudia Figueroa-Romero et al.   PLoS One

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

(2012) Y. Kawahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

microRNA-34a regulates neurite outgrowth, spinal morphology, and function

(2011) M. Agostini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The MicroRNA Spectrum in 12 Body Fluids

(2010) J. A. Weber et al.   CLINICAL CHEMISTRY

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

(2010) C. Lagier-Tourenne et al.   HUMAN MOLECULAR GENETICS

miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation

(2009) Xiaoying Wang et al.   BRAIN RESEARCH BULLETIN

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

MicroRNAs Potentiate Neural Development

(2009) Sarah K. Fineberg et al.   NEURON

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE