Review
Biochemistry & Molecular Biology
Ying-Bing Zuo, Yin-Feng Zhang, Rui Zhang, Jia-Wei Tian, Xiao-Bing Lv, Rong Li, Shu-Ping Li, Meng-Die Cheng, Jing Shan, Zheng Zhao, Hui Xin
Summary: This review provides a systematic summary of the relationship between ferroptosis-associated ncRNAs and cancer progression and highlights the regulatory roles of ncRNAs in ferroptosis. It also suggests the potential of utilizing ncRNAs as diagnostic and therapeutic biomarkers for cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Endocrinology & Metabolism
Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang, Xinyu Guo, Zhengwei Xu, Hao Yang, Dingjun Hao
Summary: Low back pain is a common musculoskeletal symptom that severely affects quality of life. Intervertebral disc degeneration is considered a major cause, and non-coding RNAs play crucial roles in its development. Their potential as therapeutic targets for IDD remain to be explored.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Haitham G. Abo-Al-Ela
Summary: ncRNAs play crucial roles in regulating and controlling cellular processes and trafficking pathways, with lncRNAs having more diverse regulatory functions compared to microRNAs. Studies in fish have highlighted the potential of harnessing these RNA types to further understand biology and utilize technologies such as RNA interference and microRNA delivery for applications in aquaculture productivity, fish health, and overall understanding of fish biology.
MOLECULAR GENETICS AND GENOMICS
(2021)
Article
Oncology
Mei Mei, Yingjun Wang, Wenting Song, Zhaoming Li, Qilong Wang, Jiayin Li, Mingzhi Zhang
Summary: The study found that circADARB1 was highly expressed in the plasma of NKTCL patients. Knockdown of circADARB1 inhibited proliferation of NKTCL cells and it bound to miR-214-3p to regulate the expression of p-Stat3.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Sumio Hayakawa, Tomokazu Ohishi, Yumiko Oishi, Mamoru Isemura, Noriyuki Miyoshi
Summary: Polyphenols have anticancer effects by acting as antioxidants and modulating cell signaling pathways, with ncRNA modulation enhancing these effects.
Review
Biochemistry & Molecular Biology
Amir Safi, Mohammadreza Saberiyan, Mohammad-Javad Sanaei, Samaneh Adelian, Fateme Davarani Asl, Mahsa Zeinaly, Mahdi Shamsi, Reza Ahmadi
Summary: Metabolic reprogramming is a well-known feature of cancer, and noncoding RNAs (ncRNAs) have been found to play a role in this process. This review focuses on the metabolism of glucose, lipids, and amino acids in cancer cells, and highlights the therapeutic potential of targeting ncRNAs in cancer treatment.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Suresh L. Mehta, Anil K. Chokkalla, Raghu Vemuganti
Summary: The mammalian brain expresses different classes of noncoding RNAs, including lncRNAs, circRNAs, and miRNAs, which play vital roles in regulating cellular processes and pathophysiological conditions through intricate networks of interactions. These interactions affect gene expression and neural function.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Immunology
Ghaidaa Raheem Lateef Al-Awsi, Methaq Hadi Lafta, Hamzah Hashim Kzar, Gulnoza Samieva, Fahad Alsaikhan, Irshad Ahmad, Marwan Mahmood Saleh, Abdelgadir Alamin Altoum, Surendar Aravindhan, Yasser Fakri Mustafa, Reza Mahmoudi, Asgar Mohammadi
Summary: This article reviews the relationship between non-coding RNAs and the PCSK9 pathway, revealing their roles in the pathogenesis of inflammatory atherosclerosis and introducing potential therapeutic interventions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Shan Wang, Ziming Wang, Hongjun Su, Fenglei Chen, Mengjun Ma, Wenhui Yu, Guiwen Ye, Shuizhong Cen, Rujia Mi, Xiaohua Wu, Wen Deng, Pei Feng, Chenying Zeng, Huiyong Shen, Yanfeng Wu
Summary: Expansion of mesenchymal stem cells (MSCs) in vitro is a necessary process before application, and functional and genomic stability play crucial roles in stem cell therapies. This study investigated the expression and co-expression profiles of coding and non-coding RNAs in human bone marrow MSCs during in vitro aging, revealing significant differences in RNA levels among different passages. Key RNAs identified in bioinformatics analysis were validated, providing important considerations for therapeutic applications of MSCs.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Mingyue Zhou, Zehua Bian, Bingxin Liu, Yi Zhang, Yulin Cao, Kaisa Cui, Shengbai Sun, Jiuming Li, Jia Zhang, Xue Wang, Chaoqun Li, Surui Yao, Yuan Yin, Bojian Fei, Zhaohui Huang
Summary: In this study, we found that MCM3AP-AS1 expression was higher in CRC tissues than in noncancerous tissues, and increased expression was associated with poor outcomes. Functional experiments revealed that silencing MCM3AP-AS1 could inhibit the proliferation, colony formation, migratory, and invasive abilities of CRC cells. In vivo experiments confirmed that silencing MCM3AP-AS1 significantly inhibited the growth and metastasis of CRC.
Review
Oncology
Barbara Montico, Giorgio Giurato, Giovanni Pecoraro, Annamaria Salvati, Alessia Covre, Francesca Colizzi, Agostino Steffan, Alessandro Weisz, Michele Maio, Luca Sigalotti, Elisabetta Fratta
Summary: Cutaneous melanoma is an aggressive disease with high mortality rates and often unresponsive to conventional therapies. Recent studies have shown aberrant expression of different types of noncoding RNAs, with microRNAs being extensively studied, while circular RNAs and long noncoding RNAs in this tumor need further exploration.
MOLECULAR ONCOLOGY
(2022)
Article
Cell Biology
Dimitrios Tsitsipatis, Jennifer L. L. Martindale, Krystyna Mazan-Mamczarz, Allison B. B. Herman, Yulan Piao, Nirad Banskota, Jen-Hao Yang, Linna Cui, Carlos Anerillas, Ming-Wen Chang, Mary Kaileh, Rachel Munk, Xiaoling Yang, Ceereena Ubaida-Mohien, Chee W. W. Chia, Ajoy C. C. Karikkineth, Linda Zukley, Jarod D'Agostino, Kotb Abdelmohsen, Nathan Basisty, Supriyo De, Luigi Ferrucci, Myriam Gorospe
Summary: We identified age-associated changes in the transcriptome, including coding and noncoding RNAs, of healthy human skin fibroblasts from 82 individuals across a wide age range. The differential abundance of 1437 coding and 1177 long noncoding RNAs was observed as a function of age. Transcription factors and RNA-binding proteins were implicated in regulating the expression of differentially abundant mRNAs and age-associated lncRNAs. These findings suggest that the identified transcripts may have potential as biomarkers and therapeutic targets for aging skin.
Review
Cell Biology
Elahe Soltani-Fard, Marzieh Asadi, Sina Taghvimi, Asma Vafadar, Parisa Vosough, Amir Tajbakhsh, Amir Savardashtaki
Summary: Endometriosis is a gynecological disorder characterized by the growth of endometrial-like cells outside the uterus. It is difficult to diagnose noninvasively, leading to delays in treatment and increased burden on patients. Exosomes, which transport bioactive molecules, including microRNAs and long noncoding RNAs, have been found to play a significant role in endometriosis development. This review focuses on the potential functions of exosomal noncoding RNAs in the therapy and diagnosis of endometriosis.
CELL AND TISSUE RESEARCH
(2023)
Review
Cell Biology
Hee K. Chung, Lan Xiao, Krishna C. Jaladanki, Jian-Ying Wang
Summary: Paneth cells are specialized intestinal epithelial cells located at the base of small intestinal crypts, playing a crucial role in maintaining gut epithelium homeostasis. Post-transcriptional regulation of Paneth cells by RNA-binding proteins (RBPs) and noncoding RNAs (ncRNAs) is essential in gut mucosal diseases where Paneth cell dysfunction is a key factor.
Review
Cell Biology
Sina Taghvimi, Omid Vakili, Elahe Soltani Fard, Seyyed Hossein Khatami, Neda Karami, Mortaza Taheri-Anganeh, Mahsa Salehi, Babak Negahdari, Hassan Ghasemi, Ahmad Movahedpour
Summary: Lung cancer therapeutic resistance, especially chemoresistance, remains a major challenge in treating this disease. Recent studies have shown that transfer of exosomes, specifically noncoding RNAs, plays a crucial role in lung cancer chemoresistance by modulating various proteins and genes. Understanding these molecular mechanisms can help improve lung cancer therapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ivano Legnini, Gaia Di Timoteo, Francesca Rossi, Mariangela Morlando, Francesca Briganti, Olga Sthandier, Alessandro Fatica, Tiziana Santini, Adrian Andronache, Mark Wade, Pietro Laneve, Nikolaus Rajewsky, Irene Bozzoni
Article
Multidisciplinary Sciences
Lorenzo Errichelli, Stefano Dini Modigliani, Pietro Laneve, Alessio Colantoni, Ivano Legnini, Davide Capauto, Alessandro Rosa, Riccardo De Santis, Rebecca Scarfo, Giovanna Peruzzi, Lei Lu, Elisa Caffarelli, Neil A. Shneider, Mariangela Morlando, Irene Bozzoni
NATURE COMMUNICATIONS
(2017)
Article
Oncology
Pietro Laneve, Agnese Po, Annarita Favia, Ivano Legnini, Vincenzo Alfano, Jessica Rea, Valerio Di Carlo, Valeria Bevilacqua, Evelina Miele, Angela Mastronuzzi, Andrea Carai, Franco Locatelli, Irene Bozzoni, Elisabetta Ferretti, Elisa Caffarelli
Article
Multidisciplinary Sciences
Pietro Laneve, Lucia Piacentini, Assunta Maria Casale, Davide Capauto, Ubaldo Gioia, Ugo Cappucci, Valerio Di Carlo, Irene Bozzoni, Patrizio Di Micco, Veronica Morea, Carmela Antonia Di Franco, Elisa Caffarelli
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Maria Di Bari, Valeria Bevilacqua, Antonella De Jaco, Pietro Laneve, Roberta Piovesana, Laura Trobiani, Claudio Talora, Elisa Caffarelli, Ada Maria Tata
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Neurosciences
Davide Capauto, Alessio Colantoni, Lei Lu, Tiziana Santini, Giovanna Peruzzi, Silvia Biscarini, Mariangela Morlando, Neil A. Shneider, Elisa Caffarelli, Pietro Laneve, Irene Bozzoni
MOLECULAR NEUROBIOLOGY
(2018)
Article
Cell & Tissue Engineering
Silvia Biscarini, Davide Capauto, Giovanna Peruzzi, Lei Lu, Alessio Colantoni, Tiziana Santini, Neil A. Shneider, Elisa Caffarelli, Pietro Laneve, Irene Bozzoni
STEM CELL RESEARCH
(2018)
Review
Pediatrics
Pietro Laneve, Jessica Rea, Elisa Caffarelli
FRONTIERS IN PEDIATRICS
(2019)
Review
Cell Biology
Pietro Laneve, Elisa Caffarelli
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Cell Biology
Jessica Rea, Valentina Menci, Paolo Tollis, Tiziana Santini, Alexandros Armaos, Maria Giovanna Garone, Federica Iberite, Andrea Cipriano, Gian Gaetano Tartaglia, Alessandro Rosa, Monica Ballarino, Pietro Laneve, Elisa Caffarelli
CELL DEATH & DISEASE
(2020)
Article
Oncology
Jessica Rea, Annamaria Carissimo, Daniela Trisciuoglio, Barbara Illi, Daniel Picard, Marc Remke, Pietro Laneve, Elisa Caffarelli
Summary: Medulloblastoma is a common malignant pediatric brain tumor, with the most aggressive subtype being Group 3. Research is shifting towards developing alternative molecular therapies due to the limitations of existing treatments. The involvement of noncoding genes, especially long noncoding RNAs, in tumorigenesis poses a significant challenge but holds promise as potential biomarkers and therapeutic targets for personalized medicine.
Article
Cell Biology
Paolo Tollis, Erika Vitiello, Francesco Migliaccio, Eleonora D'Ambra, Anna Rocchegiani, Maria Giovanna Garone, Irene Bozzoni, Alessandro Rosa, Annamaria Carissimo, Pietro Laneve, Elisa Caffarelli
Summary: This study uncovers a novel function for the lncRNA nHOTAIRM1, specifically expressed in the spinal cord, in promoting the differentiation of motor neurons (MNs) and regulating their morphology and synaptic activity. The absence of nHOTAIRM1 results in altered neurite outgrowth, impaired gene expression related to synaptic connectivity, and neurotransmission.
CELL DEATH & DISEASE
(2023)