Article
Multidisciplinary Sciences
Samira Molaei Ramshe, Hamid Ghaedi, Mir Davood Omrani, Lobat Geranpayeh, Behnam Alipour, Soudeh Ghafouri-Fard
Summary: Long non-coding RNAs play important roles in cancer development, with FOXN3-AS1 identified as a potential diagnostic marker for breast cancer due to its significantly increased expression levels in tumor samples. On the other hand, EMX2OS showed no significant difference in expression levels between tumor samples and normal adjacent tissues, but was associated with patient age. Further functional studies are recommended to explore the precise roles of these lncRNAs in breast cancer progression.
Article
Oncology
Jianhong Zhang, Zeming Hu, Chao Wen, Qicheng Liao, Baoqing He, Jing Peng, Xin Tang, Zhixi Chen, Yuankang Xie
Summary: The study found that miR-182 promotes EMT in GBC cells by targeting FOXN3, which in turn suppresses the Wnt/beta-catenin pathway. Decreased miR-182 expression led to attenuated EMT and reduced activity of beta-catenin and its downstream factors in GBC cells. Overexpression of FOXN3 improved EMT and the beta-catenin pathway.
Article
Cell Biology
Zhaowei Xu, Shuyan Liu, Chun Feng, Fuyi Xu, Demin Kong, Jia Mi, Chunhua Yang, Guilong Zhang, Pengfei Wei, Buyan-Ochir Orgil, Jonas Bergquist, Geng Tian
Summary: This study found that the expression of checkpoint suppressor 1 (CHES1) is highly associated with triple-negative breast cancer (TNBC) and plays a role in promoting the proliferation and metastasis of TNBC. Acetylation of CHES1 enhances its stability and contributes to its high abundance in TNBC. These findings highlight the significance of CHES1 acetylation in breast cancer progression.
CELL DEATH DISCOVERY
(2022)
Review
Oncology
Yuanyuan Kang, Kexin Zhang, Lixue Sun, Ying Zhang
Summary: This article provides an overview of the mechanisms and roles of FOXK2 in cancer, as well as the prognostic value of FOXK2 expression in different types of cancer. The findings will contribute to a better understanding of the therapeutic potential of FOXK2 as a target for cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Stefan Koch
Summary: This article discusses the control of the Wnt pathway by FOX proteins, and the contribution of their interaction to cancer initiation and progression. Further research on FOX biology may lead to new targeted treatments for cancer.
Article
Developmental Biology
Huanqing Zhang, Pei Zhuang, Ryan M. Welchko, Manhong Dai, Fan Meng, David L. Turner
Summary: This study reveals that miR-216b is highly expressed in postmitotic retinal amacrine cells in the mouse retina and its expression in the retina is partly regulated by the transcription factor Ptf1a. Ectopic expression of miR-216b leads to increased amacrine cell formation and decreased bipolar neuron formation in the developing retina. The researchers identify Foxn3 mRNA as a target of miR-216b and show that Foxn3 is a novel regulator of interneuron formation in the developing retina.
Review
Biochemistry & Molecular Biology
Samia S. Sadaf, Ali Hazazi, Samia S. Alkhalil, Ahad Amer Alsaiari, Amal F. Gharib, Hayaa M. Alhuthali, Shanika Rana, Abdulaziz A. Aloliqi, Alaa Abdulaziz Eisa, Mohammad Raghibul Hasan, Kapil Dev
Summary: Breast cancer is a deadly disease with global significance, and understanding its various factors, genetic mutations, and pathways is crucial for improving treatment. The forkhead-box gene family has a significant impact on the growth and progression of breast cancer. This article explores different forkhead genes, their role in cancer development, drug resistance, interaction with microRNAs, potential as therapeutic targets, and their association with stem cells.
Article
Pathology
Rui Zhang, Ziqi Meng, Xuwei Wu, Meihua Zhang, Songnan Zhang, Tiefeng Jin
Summary: The research demonstrated that Mortalin promotes proliferation, metastasis, and malignant progression of breast cancer, potentially through the Wnt/beta-Catenin signaling pathway. This suggests that Mortalin could serve as a biomarker and prognostic factor in breast cancer.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Meysam Moghbeli, Negin Taghehchian, Iman Akhlaghipour, Yalda Samsami, Amirhosein Maharati
Summary: Chemotherapy is commonly used as a first-line treatment for cancer patients, but chemo resistance can limit its effectiveness. Understanding the molecular mechanisms involved in chemo response, such as drug efflux and DNA repair, can help improve patient prognosis. In this review, the role of the FOX protein family in chemo response, particularly with DOX/PTX, is discussed. FOX proteins have been found to regulate drug efflux, autophagy, structural proteins, and signaling pathways, making them potential prognostic markers and therapeutic targets in cancer patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell Biology
Danrong Ye, Yuying Wang, Xiaochong Deng, Xiqian Zhou, Diya Liu, Baian Zhou, Wenfang Zheng, Xuehui Wang, Lin Fang
Summary: Breast cancer is a common malignant tumor in women and understanding its mechanisms is important for prognosis. Recent research suggests that dermatopontin (DPT), an extracellular matrix protein, is involved in cancer development. This study found that DNMT3a-mediated DPT promoter hypermethylation leads to downregulation of DPT in breast cancer, and low DPT expression is associated with poor prognosis. Additionally, DPT interacts with YAP to inhibit breast cancer growth and metastasis. These findings reveal the critical role of DPT in breast cancer progression and suggest potential targeted therapies.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Wei Yu, Yongkang Diao, Yi Zhang, Ying Shi, Xiangkang Lv, Chengwu Zhang, Kangjun Zhang, Weifeng Yao, Dongsheng Huang, Jungang Zhang
Summary: The study found that high expression of FOXN3 in pancreatic cancer is associated with poor prognosis, and FOXN3 is involved in the occurrence and progression of pancreatic cancer, which may be useful as a prognostic tool in pancreatic cancer immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Behzad Mansoori, Pascal H. G. Duijf, Ali Mohammadi, Elham Safarzadeh, Henrik J. Ditzel, Morten F. Gjerstorff, William Chi-Shing Cho, Behzad Baradaran
Summary: miR-142-3p directly targets the HMGA2 gene in breast cancer cells, leading to apoptosis, cell cycle arrest, and inhibition of cancer stem cell properties. This study provides evidence for miR-142-3p as a potential therapeutic target for breast cancer treatment, highlighting its role in regulating oncogenesis.
Article
Biology
Chao Song, Ting Li, Chunlei Zhang, Shufang Li, Songhui Lu, Yi Zou
Summary: Proper retinoic acid signaling is crucial for normal craniofacial development. Both excessive and deficiency of retinoic acid can lead to craniofacial malformations. Dysregulated Wnt and Shh signaling are involved in the pathogenesis of retinoic acid-induced craniofacial defects. MiR-484-Fzd5 regulatory network plays critical roles in retinoic acid-regulated craniofacial development.
LIFE SCIENCE ALLIANCE
(2023)
Article
Oncology
Andrew D. James, Theresa K. Leslie, Joshua D. Kaggie, Laura Wiggins, Lewis Patten, John Murphy O'Duinn, Swen Langer, Marie-Christine Labarthe, Frank Riemer, Gabrielle Baxter, Mary A. McLean, Fiona J. Gilbert, Aneurin J. Kennerley, William J. Brackenbury
Summary: In this study, the diagnostic and treatment-monitoring potential of sodium (Na-23) MRI in breast cancer was demonstrated. The researchers found elevated sodium concentration in tumor regions compared to non-tumor regions, and combining Na-23 MRI with other imaging measurements improved the accuracy of tumor classification. This novel MRI method also showed superior sensitivity in assessing treatment response compared to traditional methods.
BRITISH JOURNAL OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Brock Humphries, Zhishan Wang, Chengfeng Yang
Summary: Recent advances in understanding breast cancer have highlighted the key role of CSCs in progression and recurrence, with miRNAs playing a crucial role in regulating CSC characteristics. MiRNAs have the potential to serve as biomarkers and clinical therapeutics for breast cancer by targeting signaling pathways associated with CSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
James A. L. Brown
JOURNAL OF BIOLOGICAL EDUCATION
(2020)
Review
Oncology
Yihang Qi, Xiangyu Wang, Xiangyi Kong, Jie Zhai, Yi Fang, Xiaoxiang Guan, Jing Wang
CANCER CELL INTERNATIONAL
(2019)
Review
Oncology
Xiangyu Wang, Yihang Qi, Xiangyi Kong, Jie Zhai, Yalun Li, Yan Song, Jing Wang, Xiaoli Feng, Yi Fang
Letter
Oncology
Qiang Liu, Yi Fang, Jing Wang
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Oncology
Andrew McGuire, Maire-Caitlin Casey, Ronan M. Waldron, Helen Heneghan, Olga Kalinina, Emma Holian, Ailbhe McDermott, Aoife J. Lowery, John Newell, Roisin M. Dwyer, Nicola Miller, Maccon Keane, James A. L. Brown, Michael J. Kerin
Article
Oncology
Xiangyi Kong, Yihang Qi, Junjie Huang, Yang Zhao, Yongle Zhan, Xuzhen Qin, Zhihong Qi, Adejare (Jay) Atanda, Lei Zhang, Jing Wang, Yi Fang, Peng Jia, Asieh Golozar, Lin Zhang, Yu Jiang
Summary: The overall prevalence of cancer among COVID-19 patients is low, but higher in Europe. Cancer prevalence is higher in patients aged over 60. The severity and mortality rates in COVID-19 patients with cancer are relatively high, especially in Europe.
Article
Cell Biology
Maria Likhatcheva, Roben G. Gieling, James A. L. Brown, Constantinos Demonacos, Kaye J. Williams
Summary: Genotoxic stress can activate the ATM kinase, with potential involvement of Suv39H1 and Tip60 in ATM activation under hypoxic conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Li Chen, Xiangyi Kong, Yi Fang, Shishir Paunikar, Xiangyu Wang, James A. L. Brown, Emer Bourke, Xingrui Li, Jing Wang
Summary: Discoidin domain receptor tyrosine kinases (DDRs) are a type of receptor tyrosine kinases associated with various diseases, widely expressed in different cell types and involved in signaling pathways, closely related to the development and progression of solid tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Amila Suraweera, James A. L. Brown, Yi Chieh Lim, Martin F. Lavin
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Editorial Material
Cell Biology
James A. L. Brown, E. Bourke, W. W. Hancock, D. J. Richard
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
James A. L. Brown
Summary: This study shows that academic staff in the biological sciences are eager to receive formal leadership skills training, but there is no clear evidence that they have received such training. The study also found that they are more interested in systemic leadership, which is lacking in the workplace. Therefore, specific leadership skills training should be incorporated into professional development programs in the field of biological sciences.
Article
Oncology
Amirhossein Jalali, David Miresse, Matthew R. Fahey, Niamh Ni Mhaonaigh, Andrew McGuire, Emer Bourke, Michael J. Kerin, James A. L. Brown
Summary: The study demonstrates the prognostic value of systemic blood-based immunocyte ratios in neoadjuvant chemotherapy-treated breast cancer patients, with significant associations found between different immunocyte ratios and subtype-specific outcomes.
Article
Public, Environmental & Occupational Health
Xiangyu Wang, Yinqi Gao, Xue Yang, Xiangyi Kong, Zixing Wang, Yi Fang, Jing Wang
IRANIAN JOURNAL OF PUBLIC HEALTH
(2020)
Review
Oncology
Xiangyi Kong, Bolun Ai, Yiming Kong, Lijuan Su, Yunzhou Ning, Newton Howard, Shun Gong, Chen Li, Jie Wang, Wan-Ting Lee, Jing Wang, Yanguo Kong, Jingping Wang, Yi Fang
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2019)
Article
Pharmacology & Pharmacy
James A. L. Brown
PHARMACEUTICAL PATENT ANALYST
(2020)
