Anti-cancer peptide-based therapeutic strategies in solid tumors

The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapies

(2022) Hamidreza Zalpoor et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Beyond K48 and K63: non-canonical protein ubiquitination

(2021) Michal Tracz et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

BIRD-2, a BH4-domain-targeting peptide of Bcl-2, provokes Bax/Bak-independent cell death in B-cell cancers through mitochondrial Ca2+-dependent mPTP opening

(2021) Martijn Kerkhofs et al.   CELL CALCIUM

ZNF674-AS1 antagonizes miR-423-3p to induce G0/G1 cell cycle arrest in non-small cell lung cancer cells

(2021) Yu Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Revealing the Dynamic Mechanism by Which Transferrin Promotes the Cellular Uptake of HAIYPRH Peptide-Conjugated Nanostructures by Force Tracing

(2021) Siying Li et al.   MOLECULAR PHARMACEUTICS

Cancer Vaccines for Genitourinary Tumors: Recent Progresses and Future Possibilities

(2021) Brigida Anna Maiorano et al.   Vaccines

PD‐1/PD‐L1‐dependent immune response in colorectal cancer

(2020) Zahra Payandeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transformable peptide nanoparticles arrest HER2 signalling and cause cancer cell death in vivo

(2020) Lu Zhang et al.   Nature Nanotechnology

MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C

(2020) Ming Liao et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

LncRNA NNT-AS1 promotes lung squamous cell carcinoma progression by regulating the miR-22/FOXM1 axis

(2020) Jing Ma et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

New Synthesized Galloyl‐RGD Inhibits Melanogenesis by Regulating the CREB and ERK Signaling Pathway in B16F10 Melanoma Cells

(2020) Seo Yeon Shin et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Silibinin suppresses epithelial–mesenchymal transition in human non-small cell lung cancer cells by restraining RHBDD1

(2020) Suyan Xu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Recent Advances on Therapeutic Peptides for Breast Cancer Treatment

(2020) Samad Beheshtirouy et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges

(2019) Victor M. Pulgar   Frontiers in Neuroscience

Immune therapy of melanoma: Overview of therapeutic vaccines

(2019) Zahra Payandeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cancer statistics for African Americans, 2019

(2019) Carol E. DeSantis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Peptide-based targeted therapeutics and apoptosis imaging probes for cancer therapy

(2019) Sri Murugan Poongkavithai Vadevoo et al.   ARCHIVES OF PHARMACAL RESEARCH

Efficacy and Safety Analysis of Nelipepimut-S Vaccine to Prevent Breast Cancer Recurrence: A Randomized, Multicenter, Phase III Clinical Trial

(2019) Elizabeth A. Mittendorf et al.   CLINICAL CANCER RESEARCH

Bicyclic peptides: types, synthesis and applications

(2019) Shahrzad Ahangarzadeh et al.   DRUG DISCOVERY TODAY

Tumor targeting peptides: novel therapeutic strategies in glioblastoma

(2019) Drazen Raucher   CURRENT OPINION IN PHARMACOLOGY

Molecular targeted therapy of glioblastoma

(2019) Emilie Le Rhun et al.   CANCER TREATMENT REVIEWS

Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer

(2019) Katsiaryna Marhelava et al.   Cancers

Development of cell-permeable peptide-based PROTACs targeting estrogen receptor α

(2019) Yuxuan Dai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pro-apoptotic peptides-based cancer therapies: challenges and strategies to enhance therapeutic efficacy

(2018) Kyoung Ah Min et al.   ARCHIVES OF PHARMACAL RESEARCH

Seek & Destroy , use of targeting peptides for cancer detection and drug delivery

(2018) Vadim Le Joncour et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Therapeutic peptides: Historical perspectives, current development trends, and future directions

(2018) Jolene L. Lau et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Current Challenges and Opportunities in Treating Glioblastoma

(2018) Andrea Shergalis et al.   PHARMACOLOGICAL REVIEWS

Affinity maturation and characterization of the ofatumumab monoclonal antibody

(2018) Zahra Payandeh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Anti-CD37 targeted immunotherapy of B-Cell malignancies

(2018) Zahra Payandeh et al.   BIOTECHNOLOGY LETTERS

Risk Factors and Preventions of Breast Cancer

(2017) Yi-Sheng Sun et al.   International Journal of Biological Sciences

Biocompatible polymersomes-based cancer theranostics: Towards multifunctional nanomedicine

(2017) Marzieh Mohammadi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Personalized cancer vaccines: Targeting the cancer mutanome

(2017) Xiuli Zhang et al.   VACCINE

Mitochondrial VDAC1-based peptides: Attacking oncogenic properties in glioblastoma

(2017) Anna Shteinfer-Kuzmine et al.   Oncotarget

Lung Cancer-Targeting Peptides with Multi-subtype Indication for Combinational Drug Delivery and Molecular Imaging

(2017) Yi-Hsuan Chi et al.   Theranostics

Liposome-mediated RNA interference delivery against Erk1 and Erk2 does not equally promote chemosensitivity in human hepatocellular carcinoma cell line HepG2

(2017) Amir Mehdizadeh et al.   Artificial Cells Nanomedicine and Biotechnology

A pilot study of the immunogenicity of a 9-peptide breast cancer vaccine plus poly-ICLC in early stage breast cancer

(2017) Patrick M. Dillon et al.   Journal for ImmunoTherapy of Cancer

Potential role of an antimicrobial peptide, KLK in inhibiting lipopolysaccharide-induced macrophage inflammation

(2017) Pornpimon Jantaruk et al.   PLoS One

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells

(2017) Li-Min Mu et al.   Scientific Reports

Cell surface binding, uptaking and anticancer activity of L-K6, a lysine/leucine-rich peptide, on human breast cancer MCF-7 cells

(2017) Che Wang et al.   Scientific Reports

How Membrane-Active Peptides Get into Lipid Membranes

(2016) Marc-Antoine Sani et al.   ACCOUNTS OF CHEMICAL RESEARCH

Clinical Development of the E75 Vaccine in Breast Cancer

(2016) Guy T. Clifton et al.   Breast Care

MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours

(2016) Andrew R Green et al.   BRITISH JOURNAL OF CANCER

A randomized phase II clinical trial of personalized peptide vaccination with metronomic low-dose cyclophosphamide in patients with metastatic castration-resistant prostate cancer

(2016) Masanori Noguchi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A Phase 2 Randomized Controlled Trial of Personalized Peptide Vaccine Immunotherapy with Low-dose Dexamethasone Versus Dexamethasone Alone in Chemotherapy-naive Castration-resistant Prostate Cancer

(2016) Kazuhiro Yoshimura et al.   EUROPEAN UROLOGY

The development and use of the E75 (HER2 369–377) peptide vaccine

(2016) Guy T Clifton et al.   Future Oncology

Synthesis and evaluation of multivalent M2pep peptides for targeting alternatively activated M2 macrophages

(2016) Chayanon Ngambenjawong et al.   JOURNAL OF CONTROLLED RELEASE

An epirubicin-peptide conjugate with anticancer activity is dependent upon the expression level of the surface transferrin receptor

(2016) Jiadan Yang et al.   Molecular Medicine Reports

Development of a novel microbubble-liposome complex conjugated with peptide ligands targeting IL4R on brain tumor cells

(2016) SEE-HYOUNG PARK et al.   ONCOLOGY REPORTS

An update clinical application of amniotic fluid-derived stem cells (AFSCs) in cancer cell therapy and tissue engineering

(2016) Shiva Gholizadeh-Ghaleh Aziz et al.   Artificial Cells Nanomedicine and Biotechnology

Melanocortin 1 Receptor: Structure, Function, and Regulation

(2016) Erin M. Wolf Horrell et al.   Frontiers in Genetics

Targeting NF- B in glioblastoma: A therapeutic approach

(2016) D. Friedmann-Morvinski et al.   Science Advances

Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain

(2015) E. Railey White et al.   ACS Chemical Biology

Peptide vaccines in breast cancer: The immunological basis for clinical response

(2015) Lívia de Paula Peres et al.   BIOTECHNOLOGY ADVANCES

Breast cancer risk associated with benign breast disease: systematic review and meta-analysis

(2015) Sara W. Dyrstad et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy

(2015) Marsha Pellegrino et al.   CANCER RESEARCH

Association of Type and Location ofBRCA1andBRCA2Mutations With Risk of Breast and Ovarian Cancer

(2015) Timothy R. Rebbeck et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Comparative evaluation of polymersome versus micelle structures as vehicles for the controlled release of drugs

(2015) Mona Alibolandi et al.   JOURNAL OF NANOPARTICLE RESEARCH

Peptide-Based Treatment: A Promising Cancer Therapy

(2015) Yu-Feng Xiao et al.   Journal of Immunology Research

Final report of the phase I/II clinical trial of the E75 (nelipepimut-S) vaccine with booster inoculations to prevent disease recurrence in high-risk breast cancer patients

(2014) E. A. Mittendorf et al.   ANNALS OF ONCOLOGY

Entry of Cell-Penetrating Peptide Transportan 10 into a Single Vesicle by Translocating Across Lipid Membrane and Its Induced Pores

(2014) Md. Zahidul Islam et al.   BIOCHEMISTRY

Association of Insulin-Related Serum Factors with Colorectal Polyp Number and Type in Adult Males

(2014) S. S. Comstock et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Peptide-based cancer therapy: Opportunity and challenge

(2014) Dongdong Wu et al.   CANCER LETTERS

Breast cancer immunotherapy: monoclonal antibodies and peptide-based vaccines

(2014) Elham Mohit et al.   Expert Review of Clinical Immunology

XB130 promotes proliferation and invasion of gastric cancer cells

(2014) Min Shi et al.   Journal of Translational Medicine

Novel Target for Peptide-Based Imaging and Treatment of Brain Tumors

(2014) M. Hyvonen et al.   MOLECULAR CANCER THERAPEUTICS

Enhancement of the Tumor Penetration of Monoclonal Antibody by Fusion of a Neuropilin-Targeting Peptide Improves the Antitumor Efficacy

(2014) T.-H. Shin et al.   MOLECULAR CANCER THERAPEUTICS

Metastatic melanoma targeting property of a novel Tc-99m-labeled HYNIC-conjugated lactam bridge-cyclized alpha-MSH peptide

(2014) Liqin Liu et al.   NUCLEAR MEDICINE AND BIOLOGY

The CT20 peptide causes detachment and death of metastatic breast cancer cells by promoting mitochondrial aggregation and cytoskeletal disruption

(2014) M W Lee et al.   Cell Death & Disease

LDL Receptor–Related Protein-1

(2013) Steven L. Gonias et al.   AMERICAN JOURNAL OF PATHOLOGY

Malignant melanoma and melanocortin 1 receptor

(2013) A. A. Rosenkranz et al.   BIOCHEMISTRY-MOSCOW

Tumour homing peptide-functionalized porous silicon nanovectors for cancer therapy

(2013) Päivi J. Kinnari et al.   BIOMATERIALS

Suppression of colorectal cancer subcutaneous xenograft and experimental lung metastasis using nanoparticle-mediated drug delivery to tumor neovasculature

(2013) Chao Wang et al.   BIOMATERIALS

Form and Function in Cyclic Peptide Natural Products: A Pharmacokinetic Perspective

(2013) Andrew T. Bockus et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Phage protein-targeted cancer nanomedicines

(2013) V.A. Petrenko et al.   FEBS LETTERS

Phase I clinical trial of vaccination with LY6K-derived peptide in patients with advanced gastric cancer

(2013) Hajime Ishikawa et al.   Gastric Cancer

Melanocortin 1 Receptor-derived peptides are efficiently recognized by cytotoxic T lymphocytes from melanoma patients

(2013) Fermín E. González et al.   IMMUNOBIOLOGY

The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering

(2013) Fen Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peptide-Based Delivery of Oligonucleotides Across Blood–Brain Barrier Model

(2013) Artita Srimanee et al.   International Journal of Peptide Research and Therapeutics

Anticancer mechanisms of temporin-1CEa, an amphipathic α-helical antimicrobial peptide, in Bcap-37 human breast cancer cells

(2013) Che Wang et al.   LIFE SCIENCES

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

(2013) Greg M. Delgoffe et al.   NATURE

Mono and Dually Decorated Nanoliposomes for Brain Targeting, In Vitro and In Vivo Studies

(2013) E. Markoutsa et al.   PHARMACEUTICAL RESEARCH

Thermally Targeted Delivery of a c-Myc Inhibitory Polypeptide Inhibits Tumor Progression and Extends Survival in a Rat Glioma Model

(2013) Gene L. Bidwell et al.   PLoS One

Peptide-based targeting strategies for simultaneous imaging and therapy with nanovectors

(2013) Antonella Accardo et al.   POLYMER JOURNAL

VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia

(2013) T Prezma et al.   Cell Death & Disease

Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies

(2012) Sameer Agnihotri et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Anti-proliferative effect of atrial natriuretic peptide on colorectal cancer cells: Evidence for an Akt-mediated cross-talk between NHE-1 activity and Wnt/β-catenin signaling

(2012) Annalucia Serafino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Advancement in multifunctional nanoparticles for the effective treatment of cancer

(2012) Mahfoozur Rahman et al.   Expert Opinion on Drug Delivery

Phase I/II study of S-1 plus cisplatin combined with peptide vaccines for human vascular endothelial growth factor receptor 1 and 2 in patients with advanced gastric cancer

(2012) TORU MASUZAWA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Neuropilin 1 deficiency on CD4+Foxp3+regulatory T cells impairs mouse melanoma growth

(2012) Wiebke Hansen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

(2012) R. Katayama et al.   Science Translational Medicine

Personalized peptide vaccination: A novel immunotherapeutic approach for advanced cancer

(2012) Tetsuro Sasada et al.   Human Vaccines & Immunotherapeutics

STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1

(2012) Serena L. Clark et al.   Computational and Structural Biotechnology Journal

The Present and Future of Peptide Vaccines for Cancer

(2011) Craig L. Slingluff   CANCER JOURNAL

PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine

(2011) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells

(2011) J. G. Valero et al.   JOURNAL OF CELL SCIENCE

Antitumor Peptides from Marine Organisms

(2011) Lan-Hong Zheng et al.   Marine Drugs

PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation

(2011) Kariem Ezzat et al.   NUCLEIC ACIDS RESEARCH

Biological Effects of a De Novo Designed Myxoma Virus Peptide Analogue: Evaluation of Cytotoxicity on Tumor Cells

(2011) Taghrid S. Istivan et al.   PLoS One

Phase II study of personalized peptide vaccination for castration-resistant prostate cancer patients who failed in docetaxel-based chemotherapy

(2011) Masanori Noguchi et al.   PROSTATE

Angiotensin-(1-7) Reduces Fibrosis in Orthotopic Breast Tumors

(2010) K. L. Cook et al.   CANCER RESEARCH

The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma

(2010) Satoko Inoda et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Phage display selection of peptides that home to atherosclerotic plaques: IL-4 receptor as a candidate target in atherosclerosis

(2010) Hai-yan Hong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery

(2010) Zhi Jie Li et al.   JOURNAL OF CONTROLLED RELEASE

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

The ups and downs of Myc biology

(2009) Laura Soucek et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Tat-BMPs-PAMAM Conjugates Enhance Therapeutic Effect of Small Interference RNA on U251 Glioma Cells In Vitro and In Vivo

(2009) Lei Han et al.   HUMAN GENE THERAPY

The E75 HER2/neu peptide vaccine

(2008) Elizabeth A. Mittendorf et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CDK Inhibitors: Cell Cycle Regulators and Beyond

(2008) Arnaud Besson et al.   DEVELOPMENTAL CELL

Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer

(2008) Giorgio Vittorio Scagliotti et al.   JOURNAL OF CLINICAL ONCOLOGY

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients

(2008) G. Minniti et al.   JOURNAL OF NEURO-ONCOLOGY

Antitumor activity of a membrane lytic peptide cyclized with a linker sensitive to membrane type 1-matrix metalloproteinase

(2008) J. Zhong et al.   MOLECULAR CANCER THERAPEUTICS

c-Myc Is Required for Maintenance of Glioma Cancer Stem Cells

(2008) Jialiang Wang et al.   PLoS One

Studies on anticancer activities of antimicrobial peptides

(2007) David W. Hoskin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Characterization of a Novel Cytotoxic Cell‐penetrating Peptide Derived From p14ARF Protein

(2007) Henrik J Johansson et al.   MOLECULAR THERAPY