Pro-apoptotic peptides-based cancer therapies: challenges and strategies to enhance therapeutic efficacy

Apoptosis and Clearance of Apoptotic Cells

(2018) Shigekazu Nagata   Annual Review of Immunology

Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells

(2018) Raheleh Rezaei Araghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tandem-multimeric F3-gelonin fusion toxins for enhanced anti-cancer activity for prostate cancer treatment

(2017) Meong Cheol Shin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Targeting of p32 in peritoneal carcinomatosis with intraperitoneal linTT1 peptide-guided pro-apoptotic nanoparticles

(2017) Hedi Hunt et al.   JOURNAL OF CONTROLLED RELEASE

Vascular changes in tumors resistant to a vascular disrupting nanoparticle treatment

(2017) Shweta Sharma et al.   JOURNAL OF CONTROLLED RELEASE

Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer

(2017) Rehan Ahmad et al.   Molecular Cancer

Enzyme-Cleavable Polymeric Micelles for the Intracellular Delivery of Proapoptotic Peptides

(2017) Hanna B. Kern et al.   MOLECULAR PHARMACEUTICS

Systemic Delivery of Tumor-Targeted Bax-Derived Membrane-Active Peptides for the Treatment of Melanoma Tumors in a Humanized SCID Mouse Model

(2017) Anastassia Karageorgis et al.   MOLECULAR THERAPY

When the guardian sleeps: Reactivation of the p53 pathway in cancer

(2017) Olaf Merkel et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Tumor-Penetrating Nanosystem Strongly Suppresses Breast Tumor Growth

(2017) Shweta Sharma et al.   NANO LETTERS

TRAIL–NP hybrids for cancer therapy: a review

(2017) H. Belkahla et al.   Nanoscale

pH-sensitive polymeric micelles for the Co-delivery of proapoptotic peptide and anticancer drug for synergistic cancer therapy

(2017) Anbu Mozhi et al.   RSC Advances

Multivalent Polymers Displaying M2 Macrophage-Targeting Peptides Improve Target Binding Avidity and Serum Stability

(2017) Chayanon Ngambenjawong et al.   ACS Biomaterials-Science & Engineering

Evolving strategies for tumor immunotherapy: enhancing the enhancer and suppressing the suppressor

(2017) Yan Gu et al.   National Science Review

Multivalent Polymers Displaying M2 Macrophage-Targeting Peptides Improve Target Binding Avidity and Serum Stability

(2017) Chayanon Ngambenjawong et al.   ACS Biomaterials Science & Engineering

Origin of anti-tumor activity of the cysteine-containing GO peptides and further optimization of their cytotoxic properties

(2017) Irina I. Tyuryaeva et al.   Scientific Reports

RSK2 and its binding partners in cell proliferation, transformation and cancer development

(2016) Yong-Yeon Cho   ARCHIVES OF PHARMACAL RESEARCH

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

(2016) Nazila Kamaly et al.   CHEMICAL REVIEWS

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

(2016) Mahdi Karimi et al.   CHEMICAL SOCIETY REVIEWS

Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise

(2016) Kristopher A. Sarosiek et al.   FEBS Journal

Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis

(2016) Kai Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced in vivo antitumor efficacy of dual-functional peptide-modified docetaxel nanoparticles through tumor targeting and Hsp90 inhibition

(2016) Yao Jiang et al.   JOURNAL OF CONTROLLED RELEASE

Bladder tumor-targeted delivery of pro-apoptotic peptide for cancer therapy

(2016) Hyun-Kyung Jung et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis and evaluation of multivalent M2pep peptides for targeting alternatively activated M2 macrophages

(2016) Chayanon Ngambenjawong et al.   JOURNAL OF CONTROLLED RELEASE

Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting

(2016) F Wachter et al.   ONCOGENE

Preparation and Characterization of Gelonin-Melittin Fusion Biotoxin for Synergistically Enhanced Anti-Tumor Activity

(2016) Meong Cheol Shin et al.   PHARMACEUTICAL RESEARCH

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

(2016) Daniel Bobo et al.   PHARMACEUTICAL RESEARCH

iRGD-targeted delivery of a pro-apoptotic peptide activated by cathepsin B inhibits tumor growth and metastasis in mice

(2016) Wang Qifan et al.   TUMOR BIOLOGY

Multivalent Targeting Based Delivery of Therapeutic Peptide using AP1-ELP Carrier for Effective Cancer Therapy

(2016) Vijaya Sarangthem et al.   Theranostics

Tuning the anticancer activity of a novel pro-apoptotic peptide using gold nanoparticle platforms

(2016) Mohammad Akrami et al.   Scientific Reports

Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics

(2016) Peter Lönn et al.   Scientific Reports

Smac Therapeutic Peptide Nanoparticles Inducing Apoptosis of Cancer Cells for Combination Chemotherapy with Doxorubicin

(2015) Mingxing Li et al.   ACS Applied Materials & Interfaces

Magnetic iron oxide nanoparticles: Recent trends in design and synthesis of magnetoresponsive nanosystems

(2015) Etelka Tombácz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Efficient Identification of Murine M2 Macrophage Peptide Targeting Ligands by Phage Display and Next-Generation Sequencing

(2015) Gary W. Liu et al.   BIOCONJUGATE CHEMISTRY

Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy

(2015) Nohyun Lee et al.   CHEMICAL REVIEWS

Intracellular Targeting of the Oncogenic MUC1-C Protein with a Novel GO-203 Nanoparticle Formulation

(2015) M. Hasegawa et al.   CLINICAL CANCER RESEARCH

Drugs acting on homeostasis: challenging cancer cell adaptation

(2015) Maria Moschovi et al.   Expert Review of Anticancer Therapy

Multivalent display of pendant pro-apoptotic peptides increases cytotoxic activity

(2015) David S.H. Chu et al.   JOURNAL OF CONTROLLED RELEASE

Functionalized Gold Nanoparticles: Synthesis, Properties and Applications—A Review

(2015) Saji Alex et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Multifunctional superparamagnetic iron oxide nanoparticles for combined chemotherapy and hyperthermia cancer treatment

(2015) Christopher A. Quinto et al.   Nanoscale

Cancer nanomedicine: from targeted delivery to combination therapy

(2015) Xiaoyang Xu et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial targeted peptides for cancer therapy

(2015) Sadaf Farsinejad et al.   TUMOR BIOLOGY

The CNGRC-GG-D(KLAKLAK)2 peptide induces a caspase-independent, Ca2+-dependent death in human leukemic myeloid cells by targeting surface aminopeptidase N/CD13

(2015) Sandrine Bouchet et al.   Oncotarget

Enhanced antitumor effects of the BRBP1 compound peptide BRBP1-TAT-KLA on human brain metastatic breast cancer

(2015) Bo Fu et al.   Scientific Reports

Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells

(2014) Glenna Wink Foight et al.   ACS Chemical Biology

Core–Shell Nanoparticle-Based Peptide Therapeutics and Combined Hyperthermia for Enhanced Cancer Cell Apoptosis

(2014) Birju P. Shah et al.   ACS Nano

Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

(2014) Ravi V. J. Chari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy

(2014) Yinan Zhong et al.   BIOMACROMOLECULES

Novel LHRH-receptor-targeted cytolytic peptide, EP-100: first-in-human phase I study in patients with advanced LHRH-receptor-expressing solid tumors

(2014) Kelly K. Curtis et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Peptide-based cancer therapy: Opportunity and challenge

(2014) Dongdong Wu et al.   CANCER LETTERS

Novel Polymeric Nanoparticles for Intracellular Delivery of Peptide Cargos: Antitumor Efficacy of the BCL-2 Conversion Peptide NuBCP-9

(2014) M. Kumar et al.   CANCER RESEARCH

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

(2014) Erik Procko et al.   CELL

Multifunctional theranostic gold nanoparticles for targeted CT imaging and photothermal therapy

(2014) Taeyjuana Curry et al.   Contrast Media & Molecular Imaging

Targeting Tumor Suppressor p53 for Cancer Therapy: Strategies, Challenges and Opportunities

(2014) Bo Hong et al.   CURRENT DRUG TARGETS

Tumor-Penetrating iRGD Peptide Inhibits Metastasis

(2014) K. N. Sugahara et al.   MOLECULAR CANCER THERAPEUTICS

Cell-Penetrating Apoptotic Peptide/p53 DNA Nanocomplex as Adjuvant Therapy for Drug-Resistant Breast Cancer

(2014) Huiyuan Wang et al.   MOLECULAR PHARMACEUTICS

An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability

(2014) Hong-Bo Pang et al.   Nature Communications

Nanoparticles for Combination Drug Therapy

(2013) Liang Ma et al.   ACS Nano

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

(2013) Nicolas Bertrand et al.   ADVANCED DRUG DELIVERY REVIEWS

A specific cell-penetrating peptide induces apoptosis in SKOV3 cells by down-regulation of Bcl-2

(2013) Chuying Ma et al.   BIOTECHNOLOGY LETTERS

A new anti-cancer strategy of damaging mitochondria by pro-apoptotic peptide functionalized gold nanoparticles

(2013) Wei-Hai Chen et al.   CHEMICAL COMMUNICATIONS

Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface-Associated GRP78

(2013) Y. R. Miao et al.   CLINICAL CANCER RESEARCH

Cell-penetrating peptides: 20 years later, where do we stand?

(2013) Chérine Bechara et al.   FEBS LETTERS

Targeting acute myeloid leukemia with a proapoptotic peptide conjugated to a toll-like receptor 2-mediated cell-penetrating peptide

(2013) Ke Li et al.   INTERNATIONAL JOURNAL OF CANCER

Cell-penetrating peptides: Achievements and challenges in application for cancer treatment

(2013) Meong Cheol Shin et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Multifunctional Envelope-Type Mesoporous Silica Nanoparticles for Tumor-Triggered Targeting Drug Delivery

(2013) Jing Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

BH3 Mimetics: Status of the Field and New Developments

(2013) C. Billard   MOLECULAR CANCER THERAPEUTICS

Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival

(2013) M. Cieslewicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia

(2013) T Prezma et al.   Cell Death & Disease

Dual-Targeting Pro-apoptotic Peptide for Programmed Cancer Cell Death via Specific Mitochondria Damage

(2013) Wei-Hai Chen et al.   Scientific Reports

Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides

(2013) Kelly C. L. Mulder et al.   Frontiers in Microbiology

From antimicrobial to anticancer peptides. A review

(2013) Diana Gaspar et al.   Frontiers in Microbiology

Stimuli-responsive polymers: Biomedical applications and challenges for clinical translation

(2012) Allan S. Hoffman   ADVANCED DRUG DELIVERY REVIEWS

Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules

(2012) Leonid Vigderman et al.   ADVANCED DRUG DELIVERY REVIEWS

Construction and expression of sTRAIL–melittin combining enhanced anticancer activity with antibacterial activity in Escherichia coli

(2012) Hongyan Liu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

De Novo Design of a Tumor-Penetrating Peptide

(2012) L. Alberici et al.   CANCER RESEARCH

A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics

(2012) Stephanie D. Steichen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Identification of a Novel Peptide Ligand of Human Transfrrin Receptor 1 for Targeted Tumor Delivery Drug

(2012) Qin Xin et al.   PROTEIN AND PEPTIDE LETTERS

Aptamer-conjugated nanomaterials and their applications

(2011) Liu Yang et al.   ADVANCED DRUG DELIVERY REVIEWS

The transferrin receptor and the targeted delivery of therapeutic agents against cancer

(2011) Tracy R. Daniels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells

(2011) Megumi Kawamoto et al.   BMC CANCER

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Tumor Vasculature Targeting Through NGR Peptide-Based Drug Delivery Systems

(2011) Angelo Corti et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Delivery of Intracellular-Acting Biologics in Pro-Apoptotic Therapies

(2011) Hongmei Li et al.   CURRENT PHARMACEUTICAL DESIGN

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Transtumoral targeting enabled by a novel neuropilin-binding peptide

(2011) L Roth et al.   ONCOGENE

Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma

(2011) L. Agemy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer theranostics: the rise of targeted magnetic nanoparticles

(2011) Adam J. Cole et al.   TRENDS IN BIOTECHNOLOGY

Tumor delivery of macromolecular drugs based on the EPR effect

(2010) Vladimir Torchilin   ADVANCED DRUG DELIVERY REVIEWS

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Anti-apoptosis and cell survival: A review

(2010) Liam Portt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Light induced drug delivery into cancer cells

(2010) Yosi Shamay et al.   BIOMATERIALS

Induction of Ca2+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction

(2010) F. Zhong et al.   BLOOD

Induction of Cancer Cell Death by Self-assembling Nanostructures Incorporating a Cytotoxic Peptide

(2010) S. M. Standley et al.   CANCER RESEARCH

Multivalent DR5 Peptides Activate the TRAIL Death Pathway and Exert Tumoricidal Activity

(2010) V. Pavet et al.   CANCER RESEARCH

A novel hybrid peptide targeting EGFR-expressing cancers

(2010) Masayuki Kohno et al.   EUROPEAN JOURNAL OF CANCER

Synthetic constrained peptide selectively binds and antagonizes death receptor 5

(2010) Johanna Vrielink et al.   FEBS Journal

Amphipathic Tail-anchoring Peptide and Bcl-2 Homology Domain-3 (BH3) Peptides from Bcl-2 Family Proteins Induce Apoptosis through Different Mechanisms

(2010) Jae-Kyun Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting of drugs and nanoparticles to tumors

(2010) Erkki Ruoslahti et al.   JOURNAL OF CELL BIOLOGY

Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma

(2010) Fernanda I. Staquicini et al.   JOURNAL OF CLINICAL INVESTIGATION

Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules

(2010) Pål Kristian Selbo et al.   JOURNAL OF CONTROLLED RELEASE

Targeted delivery of a proapoptotic peptide to tumorsin vivo

(2010) Sandrine Dufort et al.   JOURNAL OF DRUG TARGETING

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Cell Death-Inducing Activity of the Peptide Containing Noxa Mitochondrial-Targeting Domain Is Associated with Calcium Release

(2009) Y.-W. Seo et al.   CANCER RESEARCH

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Targeting AKT with the proapoptotic peptide, TAT-CTMP: A novel strategy for the treatment of human pancreatic adenocarcinoma

(2009) Peter O. Simon et al.   INTERNATIONAL JOURNAL OF CANCER

Photochemical internalization (PCI) in cancer therapy: From bench towards bedside medicine

(2009) Ole-Jacob Norum et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Intracellular Delivery of a Proapoptotic Peptide via Conjugation to a RAFT Synthesized Endosomolytic Polymer

(2009) Craig L. Duvall et al.   MOLECULAR PHARMACEUTICS

Inhibiting the inhibitors: Retro-inverso Smac peptides

(2009) Julia Hossbach et al.   PEPTIDES

Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers☆

(2008) I SLOWING et al.   ADVANCED DRUG DELIVERY REVIEWS

Neuropilin-1 is a receptor for transforming growth factor β-1, activates its latent form, and promotes regulatory T cell activity

(2008) Yelena Glinka et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY