Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

Neuregulin-4 is an angiogenic factor that is critically involved in the maintenance of adipose tissue vasculature

(2018) Dhite Bayu Nugroho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Family with sequence similarity 13, member A modulates adipocyte insulin signaling and preserves systemic metabolic homeostasis

(2018) Donytra Arby Wardhana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of neuregulin-4 in adipocytes improves metabolic health by enhancing adipose tissue angiogenesis

(2018) Dhite Bayu Nugroho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Revisiting Cardiac Cellular CompositionNovelty and Significance

(2015) Alexander R. Pinto et al.   CIRCULATION RESEARCH

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

(2015) Allyson K. Palmer et al.   DIABETES

Ageing research: Blood to blood

(2015) Megan Scudellari   NATURE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements

(2015) Thomas S. Morley et al.   Nature Communications

Aging differentially alters the expression of angiogenic genes in a tissue-dependent manner

(2014) Yoshiaki Shimoda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions

(2014) J. B. Halter et al.   DIABETES

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Adipose Vascular Endothelial Growth Factor Regulates Metabolic Homeostasis through Angiogenesis

(2013) Hoon-Ki Sung et al.   Cell Metabolism

Accelerated fat cell aging links oxidative stress and insulin resistance in adipocytes

(2013) Finny Monickaraj et al.   JOURNAL OF BIOSCIENCES

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Ecscr regulates insulin sensitivity and predisposition to obesity by modulating endothelial cell functions

(2013) Yoshiki Akakabe et al.   Nature Communications

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Defining vascular aging and cardiovascular risk

(2012) Stéphane Laurent   JOURNAL OF HYPERTENSION

Dichotomous effects of VEGF-A on adipose tissue dysfunction

(2012) K. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of cellular senescence by developmentally regulated FGF receptors in mesenchymal stem cells

(2011) D. L. Coutu et al.   BLOOD

Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization

(2011) Bi-Sen Ding et al.   CELL

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Loss of Bcl-2 During the Senescence Exacerbates the Impaired Angiogenic Functions in Endothelial Cells by Deteriorating the Mitochondrial Redox State

(2011) Maki Uraoka et al.   HYPERTENSION

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Inflammasome activation and IL-1  target IL-1  for secretion as opposed to surface expression

(2011) A. Fettelschoss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

The Many Faces of Endothelial Microparticles

(2010) Françoise Dignat-George et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Accumulation of protein carbonyls within cerebellar astrocytes in murine experimental autoimmune encephalomyelitis

(2010) Jianzheng Zheng et al.   JOURNAL OF NEUROSCIENCE RESEARCH

IGF-1, oxidative stress and atheroprotection

(2010) Yusuke Higashi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular endothelial senescence: from mechanisms to pathophysiology

(2008) Jorge D. Erusalimsky   JOURNAL OF APPLIED PHYSIOLOGY

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY