Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis

Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome

(2022) Wen-Bing Jin et al.   CELL

Cytokine Regulation and Function in T Cells

(2021) Chen Dong   Annual Review of Immunology

Modulation of the Gut Microbiota-Farnesoid X Receptor Axis Improves Deoxycholic Acid-induced Intestinal Inflammation in Mice

(2021) Mengque Xu et al.   Journal of Crohns & Colitis

The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer

(2021) Lulu Sun et al.   Nature Reviews Gastroenterology & Hepatology

Microbial Hydroxysteroid Dehydrogenases: From Alpha to Omega

(2021) Heidi L. Doden et al.   Microorganisms

CAR directs T cell adaptation to bile acids in the small intestine

(2021) Mei Lan Chen et al.   NATURE

A Gut-Restricted Lithocholic Acid Analog as an Inhibitor of Gut Bacterial Bile Salt Hydrolases

(2021) Arijit A. Adhikari et al.   ACS Chemical Biology

A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1

(2021) Wei Li et al.   Cell Host & Microbe

Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease

(2021) Jonathan Wei Jie Lee et al.   Cell Host & Microbe

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

(2021) Yuko Sato et al.   NATURE

Ursodeoxycholic acid suppresses the malignant progression of colorectal cancer through TGR5-YAP axis

(2021) Huan Zhang et al.   Cell Death Discovery

Colorectal cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation

(2020) Sidhartha R. Sinha et al.   Cell Host & Microbe

Global chemical effects of the microbiome include new bile-acid conjugations

(2020) Robert A. Quinn et al.   NATURE

Development of a covalent inhibitor of gut bacterial bile salt hydrolases

(2020) Arijit A. Adhikari et al.   Nature Chemical Biology

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

(2020) Aonghus Lavelle et al.   Nature Reviews Gastroenterology & Hepatology

Deoxycholic Acid-Induced Gut Dysbiosis Disrupts Bile Acid Enterohepatic Circulation and Promotes Intestinal Inflammation

(2020) Mengque Xu et al.   DIGESTIVE DISEASES AND SCIENCES

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

(2020) Giovanni Sorrentino et al.   GASTROENTEROLOGY

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

(2020) Clarissa Campbell et al.   NATURE

Fibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in presence of Farnesoid X Receptor

(2020) Raffaella Maria Gadaleta et al.   EBioMedicine

Metagenomic analysis of the human microbiome reveals the association between the abundance of gut bile salt hydrolases and host health

(2020) Baolei Jia et al.   Gut Microbes

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

(2020) Masanori Funabashi et al.   NATURE

Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation

(2020) Lingyu Wang et al.   Gut Microbes

Effects of ursodeoxycholic acid on the gut microbiome and colorectal adenoma development

(2019) Talima Pearson et al.   Cancer Medicine

Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (BSH) genes based on worldwide human gut microbiome

(2019) Ziwei Song et al.   Microbiome

Interplay between bile acids and the gut microbiota promotes intestinal carcinogenesis

(2019) Sinan Wang et al.   MOLECULAR CARCINOGENESIS

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

(2019) Jason Lloyd-Price et al.   NATURE

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

(2019) Jakob Wirbel et al.   NATURE MEDICINE

Chemoproteomic Profiling of Gut Microbiota-Associated Bile Salt Hydrolase Activity

(2019) Bibudha Parasar et al.   ACS Central Science

Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

(2019) Shinichi Yachida et al.   NATURE MEDICINE

Microbial genes and pathways in inflammatory bowel disease

(2019) Melanie Schirmer et al.   NATURE REVIEWS MICROBIOLOGY

Pre-diagnostic plasma bile acid levels and colon cancer risk: A prospective study

(2019) Tilman Kühn et al.   JNCI-Journal of the National Cancer Institute

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

(2019) Xinyang Song et al.   NATURE

Primary biliary cholangitis: Old and novel therapy

(2018) Annarosa Floreani et al.   European Journal of Internal Medicine

Human T Cell Development, Localization, and Function throughout Life

(2018) Brahma V. Kumar et al.   IMMUNITY

A selective gut bacterial bile salt hydrolase alters host metabolism

(2018) Lina Yao et al.   eLife

Metabolism of Oxo-Bile Acids and Characterization of Recombinant 12α-Hydroxysteroid Dehydrogenases from Bile Acid 7α-Dehydroxylating Human Gut Bacteria

(2018) Heidi Doden et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid

(2018) Elliot S. Friedman et al.   GASTROENTEROLOGY

Gut microbiome structure and metabolic activity in inflammatory bowel disease

(2018) Eric A. Franzosa et al.   Nature Microbiology

The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids

(2017) Wei Cao et al.   IMMUNITY

Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents

(2017) Masamichi Watanabe et al.   JOURNAL OF LIPID RESEARCH

Bile acids and colon cancer: Is FXR the solution of the conundrum?

(2017) Raffaella Maria Gadaleta et al.   MOLECULAR ASPECTS OF MEDICINE

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

(2017) Wei Jia et al.   Nature Reviews Gastroenterology & Hepatology

Regulatory T cells in cancer immunotherapy

(2016) Atsushi Tanaka et al.   CELL RESEARCH

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

(2016) Takuro Saito et al.   NATURE MEDICINE

Signals from the gut microbiota to distant organs in physiology and disease

(2016) Bjoern O Schroeder et al.   NATURE MEDICINE

Diet, microorganisms and their metabolites and colon cancer

(2016) Stephen J. D. O'Keefe   Nature Reviews Gastroenterology & Hepatology

A biosynthetic pathway for a prominent class of microbiota-derived bile acids

(2015) A Sloan Devlin et al.   Nature Chemical Biology

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

(2015) E. Sefik et al.   SCIENCE

A prospective study of serum metabolites and colorectal cancer risk

(2014) Amanda J. Cross et al.   CANCER

Inflammatory Bowel Disease as a Model for Translating the Microbiome

(2014) Curtis Huttenhower et al.   IMMUNITY

Discovery of Bile Salt Hydrolase Inhibitors Using an Efficient High-Throughput Screening System

(2014) Katie Smith et al.   PLoS One

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

A tale of two diseases: The history of inflammatory bowel disease

(2013) Daniel J. Mulder et al.   Journal of Crohns & Colitis

Human Gut Microbiome and Risk for Colorectal Cancer

(2013) Jiyoung Ahn et al.   JNCI-Journal of the National Cancer Institute

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Stool Microbiome and Metabolome Differences between Colorectal Cancer Patients and Healthy Adults

(2013) Tiffany L. Weir et al.   PLoS One

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

(2013) Fei Li et al.   Nature Communications

Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease

(2012) Derrick E. Fouts et al.   JOURNAL OF HEPATOLOGY

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice

(2012) Suzanne Devkota et al.   NATURE

Leaky gut and the liver: A role for bacterial translocation in nonalcoholic steatohepatitis

(2012) Yaron Ilan   WORLD JOURNAL OF GASTROENTEROLOGY

Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats

(2011) K.B.M. Saiful Islam et al.   GASTROENTEROLOGY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

Probiotic Bile Salt Hydrolase: Current Developments and Perspectives

(2009) Anil K. Patel et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Metabolomics Reveals Metabolic Biomarkers of Crohn's Disease

(2009) Janet Jansson et al.   PLoS One

Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

(2008) B. V. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal bile acid physiology and pathophysiology

(2008) Olga Martínez-Augustin et al.   WORLD JOURNAL OF GASTROENTEROLOGY