A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

(2021) Yuko Sato et al.   NATURE

Development of a covalent inhibitor of gut bacterial bile salt hydrolases

(2020) Arijit A. Adhikari et al.   Nature Chemical Biology

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

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A metabolic pathway for bile acid dehydroxylation by the gut microbiome

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Regulatory T cell adaptation in the intestine and skin

(2019) Natasha Whibley et al.   NATURE IMMUNOLOGY

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(2019) Jason Lloyd-Price et al.   NATURE

Streamlined Genetic Manipulation of Diverse Bacteroides and Parabacteroides Isolates from the Human Gut Microbiota

(2019) Leonor García-Bayona et al.   mBio

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

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A selective gut bacterial bile salt hydrolase alters host metabolism

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Intestinal immune dysregulation driven by dysbiosis promotes barrier disruption and bacterial translocation in rats with cirrhosis

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Gut microbiome structure and metabolic activity in inflammatory bowel disease

(2018) Eric A. Franzosa et al.   Nature Microbiology

Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor

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A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients

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Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

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A biosynthetic pathway for a prominent class of microbiota-derived bile acids

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(2015) Nuala A. O'Leary et al.   NUCLEIC ACIDS RESEARCH

Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation

(2015) T. W. Cullen et al.   SCIENCE

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

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Bile Acid-Activated Receptors, Intestinal Microbiota, and the Treatment of Metabolic Disorders

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High-Specificity Targeted Functional Profiling in Microbial Communities with ShortBRED

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Human Gut Microbes Use Multiple Transporters to Distinguish Vitamin B12 Analogs and Compete in the Gut

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Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

(2014) Charlie G. Buffie et al.   NATURE

Complex host genetics influence the microbiome in inflammatory bowel disease

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Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis

(2013) Takashi Sekiya et al.   NATURE IMMUNOLOGY

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

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Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion

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Alterations in the gut microbiome of children with severe ulcerative colitis

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T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

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A Closer Look at Bacteroides: Phylogenetic Relationship and Genomic Implications of a Life in the Human Gut

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(2011) Manimozhiyan Arumugam et al.   NATURE

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A stereoselective synthesis of the allo-bile acids from the 5β-isomers

(2011) Qingjiang Li et al.   TETRAHEDRON LETTERS

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells

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Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

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Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

Isolation and characterization of a bile acid inducible 7α-dehydroxylating operon in Clostridium hylemonae TN271

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The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

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Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Targeting bile-acid signalling for metabolic diseases

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Clostridium scindens baiCD and baiH genes encode stereo-specific 7α/7β-hydroxy-3-oxo-Δ4-cholenoic acid oxidoreductases☆

(2007) D KANG   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS