Ursodeoxycholic acid suppresses the malignant progression of colorectal cancer through TGR5-YAP axis

Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer

(2021) Huanji Xu et al.   Cell Death Discovery

TGR5 receptor activation attenuates diabetic retinopathy through suppression of RhoA/ROCK signaling

(2020) Lingpeng Zhu et al.   FASEB JOURNAL

FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis

(2020) Katrin Panzitt et al.   JOURNAL OF HEPATOLOGY

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

(2020) Giovanni Sorrentino et al.   GASTROENTEROLOGY

Structural basis of GPBAR activation and bile acid recognition

(2020) Fan Yang et al.   NATURE

Synaptopodin Is Dispensable for Normal Podocyte Homeostasis but Is Protective in the Context of Acute Podocyte Injury

(2020) Liang Ning et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation

(2019) Choong-kun Lee et al.   SCIENCE

MEK nuclear localization promotes YAP stability via sequestering β-TrCP in KRAS mutant cancer cells

(2019) Huanji Xu et al.   CELL DEATH AND DIFFERENTIATION

Ursodeoxycholic Acid Accelerates Bile Acid Enterohepatic Circulation

(2019) Yunjing Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Biosynthesis, Signaling, and Neurological Functions of Bile Acids

(2019) Yoshimitsu Kiriyama et al.   Biomolecules

TGR5 agonist ameliorates insulin resistance in skeletal muscles and improves glucose homeostasis in diabetic mice

(2019) Suling Huang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Diversification of host bile acids by members of the gut microbiota

(2019) Jenessa A. Winston et al.   Gut Microbes

Conjugated Bile Acids Promote Invasive Growth of Esophageal Adenocarcinoma Cells and Cancer Stem Cell Expansion via Sphingosine 1-Phosphate Receptor 2–Mediated YAP Activation

(2018) Runping Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney disease

(2018) Jing Cai et al.   GENES & DEVELOPMENT

EGFR-PI3K-PDK1 pathway regulates YAP signaling in hepatocellular carcinoma: the mechanism and its implications in targeted therapy

(2018) Hongwei Xia et al.   Cell Death & Disease

ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells

(2018) Sheng Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Lithocholic Acid Stimulates IL-8 Expression in Human Colorectal Cancer Cells Via Activation of Erk1/2 MAPK and Suppression of STAT3 Activity

(2017) Thi Thinh Nguyen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

(2017) Wei Jia et al.   Nature Reviews Gastroenterology & Hepatology

Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres

(2017) Patrick W. Oakes et al.   Nature Communications

Clinical relevance of the bile acid receptor TGR5 in metabolism

(2017) F Samuel van Nierop et al.   Lancet Diabetes & Endocrinology

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

Primary biliary cirrhosis

(2015) Elizabeth J Carey et al.   LANCET

Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis

(2015) Hongtan Wu et al.   Nature Communications

Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1)

(2014) Valentina Sepe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes

(2013) Minchul Kim et al.   EMBO JOURNAL

Bile Acids Activate YAP to Promote Liver Carcinogenesis

(2013) Sayeepriyadarshini Anakk et al.   Cell Reports

Expression of bile acid receptor TGR5 in gastric adenocarcinoma

(2012) Weibiao Cao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway

(2012) Senthilkumar Rajagopal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Stromal COX-2 signaling activated by deoxycholic acid mediates proliferation and invasiveness of colorectal epithelial cancer cells

(2012) Yingting Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The chemopreventive agent ursodeoxycholic acid inhibits proliferation of colon carcinoma cells by suppressing c-Myc expression

(2012) Roser Peiró-Jordán et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Celecoxib and tauro-ursodeoxycholic acid co-treatment inhibits cell growth in familial adenomatous polyposis derived LT97 colon adenoma cells

(2012) Bjorn W.H. van Heumen et al.   EXPERIMENTAL CELL RESEARCH

Deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis

(2012) Wei-Dong Chen et al.   HEPATOLOGY

High-Dose Ursodeoxycholic Acid Is Associated With the Development of Colorectal Neoplasia in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis

(2011) John E Eaton et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

cAMP/PKA antagonizes thrombin-induced inactivation of endothelial myosin light chain phosphatase: role of CPI-17

(2010) Muhammad Aslam et al.   CARDIOVASCULAR RESEARCH

Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma

(2009) Michelle Z. Xu et al.   CANCER

Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma

(2009) J. Hong et al.   GUT