Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia/reoxygenation-induced upregulation of miRNA-542-5p aggravated cardiomyocyte injury by repressing autophagy

(2021) Fei Wang et al.   Human Cell

Iron overload as a risk factor for hepatic ischemia‐reperfusion injury in liver transplantation: Potential role of ferroptosis

(2020) Naoya Yamada et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Transferrin Receptor Is a Specific Ferroptosis Marker

(2020) Huizhong Feng et al.   Cell Reports

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Transferrin and transferrin receptors update

(2018) Hiroshi Kawabata   FREE RADICAL BIOLOGY AND MEDICINE

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load

(2018) Carine Fillebeen et al.   BLOOD

Regulating ferroportin-1 and transferrin receptor-1 expression: A novel function of hydrogen sulfide

(2018) Meng-Wan Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux

(2018) Wei Wan et al.   MOLECULAR CELL

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

The transferrin receptor: the cellular iron gate

(2017) Elena Gammella et al.   Metallomics

The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1

(2017) Keith Dadson et al.   Scientific Reports

4-Hydroxy-2-nonenal: a critical target in oxidative stress?

(2016) Mason Breitzig et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The myeloid heat shock transcription factor 1/β-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury

(2016) Shi Yue et al.   HEPATOLOGY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Rapamycin Protection of Livers From Ischemia and Reperfusion Injury Is Dependent on Both Autophagy Induction and Mammalian Target of Rapamycin Complex 2-Akt Activation

(2015) Jianjun Zhu et al.   TRANSPLANTATION

MiR-542-5p is a negative prognostic factor and promotes osteosarcoma tumorigenesis by targeting HUWE1

(2015) Dong-dong Cheng et al.   Oncotarget

Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions

(2014) Linyuan Wang et al.   DIABETOLOGIA

Quantitative Lys-ϵ-Gly-Gly (diGly) Proteomics Coupled with Inducible RNAi Reveals Ubiquitin-mediated Proteolysis of DNA Damage-inducible Transcript 4 (DDIT4) by the E3 Ligase HUWE1

(2014) Joel W. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu

(2013) Carmen Peralta et al.   JOURNAL OF HEPATOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

The E3 ubiquitin ligase Mule acts through the ATM–p53 axis to maintain B lymphocyte homeostasis

(2012) Zhenyue Hao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A highly selective turn-on fluorescent probe for iron(ii) to visualize labile iron in living cells

(2012) Tasuku Hirayama et al.   Chemical Science

Liver Ischemia and Reperfusion Injury: New Insights into Mechanisms of Innate-Adaptive Immune-Mediated Tissue Inflammation

(2011) Y. Zhai et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2

(2011) J. Zhang et al.   GENES & DEVELOPMENT

Transferrin-Directed Internalization and Cycling of Transferrin Receptor 2

(2009) Juxing Chen et al.   TRAFFIC

The Small-Molecule Iron Transport Inhibitor Ferristatin/NSC306711 Promotes Degradation of the Transferrin Receptor

(2008) Lior Horonchik et al.   CHEMISTRY & BIOLOGY

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein

(2008) Xudong Zhao et al.   NATURE CELL BIOLOGY

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

(2008) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA