Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions

Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex

(2014) Linyuan Wang et al.   NATURE MEDICINE

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic  -cell function in diabetes

(2014) A. Hoshino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

(2013) S. Inoue et al.   GENES & DEVELOPMENT

Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate

(2013) Erica P. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 ubiquitin ligase Mule acts through the ATM–p53 axis to maintain B lymphocyte homeostasis

(2012) Zhenyue Hao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The double life of MULE in preeclamptic and IUGR placentae

(2012) A Rolfo et al.   Cell Death & Disease

Mitochondrion-dependent N-terminal Processing of Outer Membrane Mcl-1 Protein Removes an Essential Mule/Lasu1 Protein-binding Site

(2011) Matthew R. Warr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation ofarf-bp1Induces p53 Activation and Diabetic Phenotypes in Mice

(2011) Ning Kon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of Pten in Pancreatic  -Cells Protects Against Deficient  -Cell Mass and Function in Mouse Models of Type 2 Diabetes

(2010) L. Wang et al.   DIABETES

Conditional Gene Targeting in Mouse Pancreatic  -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

(2010) B. Wicksteed et al.   DIABETES

p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress

(2010) Esteban N. Gurzov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Erythropoietin protects against diabetes through direct effects on pancreatic β cells

(2010) Diana Choi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Mdm2-mediated ubiquitylation: p53 and beyond

(2009) J-C Marine et al.   CELL DEATH AND DIFFERENTIATION

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair

(2009) Jason L Parsons et al.   EMBO JOURNAL

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein

(2008) Xudong Zhao et al.   NATURE CELL BIOLOGY