The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1

Epidemiology and aetiology of heart failure

(2016) Boback Ziaeian et al.   Nature Reviews Cardiology

HUWE1 mutations in Juberg-Marsidi and Brooks syndromes: the results of an X-chromosome exome sequencing study

(2016) Michael J Friez et al.   BMJ Open

Targeting the Ubiquitin-Proteasome System in Heart Disease: The Basis for New Therapeutic Strategies

(2014) Oliver Drews et al.   ANTIOXIDANTS & REDOX SIGNALING

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase

(2014) S. Peter et al.   EMBO Molecular Medicine

PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

(2014) V. A. Morais et al.   SCIENCE

Regulation of fetal gene expression in heart failure

(2013) Ellen Dirkx et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes

(2013) Stephen C. Kolwicz et al.   CIRCULATION RESEARCH

Role of the Ubiquitin Proteasome System in the Heart

(2013) Julia Pagan et al.   CIRCULATION RESEARCH

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

(2013) S. Inoue et al.   GENES & DEVELOPMENT

The role of ubiquitin ligases in cardiac disease

(2013) Monte S. Willis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury

(2013) Hilary K. Siddall et al.   PLoS One

Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease

(2012) Peter A. Hecker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The E3 ubiquitin ligase Mule acts through the ATM–p53 axis to maintain B lymphocyte homeostasis

(2012) Zhenyue Hao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic effects of glutamine on the heart: Anaplerosis versus the hexosamine biosynthetic pathway

(2012) Benjamin Lauzier et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Oxidative stress and cardiac hypertrophy: a review

(2012) Subir Kumar Maulik et al.   TOXICOLOGY MECHANISMS AND METHODS

Back to your heart: Ubiquitin proteasome system-regulated signal transduction

(2011) Andrea L. Portbury et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function

(2011) F. Billia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice

(2010) Preeti Ahuja et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload

(2008) Nadia Hedhli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

Acute severe cardiac failure in a myeloma patient due to proteasome inhibitor bortezomib

(2008) Abdullah Hacihanefioglu et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Metabolic Reserve of the Heart: The Forgotten Link Between Contraction and Coronary Flow

(2008) Christos Kassiotis et al.   PROGRESS IN CARDIOVASCULAR DISEASES