Dexmedetomidine attenuates hypoxia‐induced cardiomyocyte injury by promoting telomere/telomerase activity: Possible involvement of ERK1/2‐Nrf2 signaling pathway

Telomerase as a Therapeutic Target in Cardiovascular Disease

(2021) Jedrzej Hoffmann et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidative Stress-Responsive MicroRNAs in Heart Injury

(2020) Branislav Kura et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dexmedetomidine Exerted Anti-arrhythmic Effects in Rat With Ischemic Cardiomyopathy via Upregulation of Connexin 43 and Reduction of Fibrosis and Inflammation

(2020) Shu-jie Wu et al.   Frontiers in Physiology

Telomeres and Telomerase in Heart Ontogenesis, Aging and Regeneration

(2020) Denis Nalobin et al.   Cells

Hypotheses, rationale, design, and methods for prognostic evaluation of a randomized comparison between patients with coronary artery disease associated with ischemic cardiomyopathy who undergo medical or surgical treatment: MASS-VI (HF)

(2020) Paulo Cury Rezende et al.   Trials

Dexmedetomidine pretreatment attenuates myocardial ischemia reperfusion induced acute kidney injury and endoplasmic reticulum stress in human and rat

(2020) Chaoliang Tang et al.   LIFE SCIENCES

Dexmedetomidine Attenuates Cellular Injury and Apoptosis in H9c2 Cardiomyocytes by Regulating p-38MAPK and Endoplasmic Reticulum Stress

(2020) Zhipeng Zhu et al.   Drug Design Development and Therapy

Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV + Individuals: Implications for Atherogenesis

(2019) Meera V Singh et al.   CIRCULATION

Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest

(2019) Elisa Coluzzi et al.   Cells

Dexmedetomidine improves cerebral ischemia-reperfusion injury in rats via ERK-CREB signaling pathway

(2019) Lu Teng et al.   World Neurosurgery

Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary

(2019) Nana Akino et al.   Reproductive Biology and Endocrinology

Dexmedetomidine preconditioning attenuates ischemia/reperfusion injury in isolated rat hearts with endothelial dysfunction

(2019) Liang He et al.   BIOMEDICINE & PHARMACOTHERAPY

Myocardial ischemia and coronary disease in heart failure

(2019) Beniamino R. Pagliaro et al.   HEART FAILURE REVIEWS

The Interstitium in the Hypertrophied Heart

(2019) Brian P. Halliday et al.   JACC-Cardiovascular Imaging

Structural Biology of Telomerase

(2019) Yaqiang Wang et al.   Cold Spring Harbor Perspectives in Biology

Role of the Extracellular Signal-Regulated Kinase 1/2 Signaling Pathway in Ischemia-Reperfusion Injury

(2019) Tingting Kong et al.   Frontiers in Physiology

Stable Ischemic Heart Disease

(2019) Richmond Doxey   ANNALS OF INTERNAL MEDICINE

Dexmedetomidine Maintains Its Direct Cardioprotective Effect Against Ischemia/Reperfusion Injury in Hypertensive Hypertrophied Myocardium

(2018) Yusuke Yoshikawa et al.   ANESTHESIA AND ANALGESIA

Impact of oxidative stress on telomere biology

(2018) Wareed Ahmed et al.   DIFFERENTIATION

Sulfiredoxin-1 enhances cardiac progenitor cell survival against oxidative stress via the upregulation of the ERK/NRF2 signal pathway

(2018) Xiuchun Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heat-shock transcription factor 1 is critically involved in the ischaemia-induced cardiac hypertrophy via JAK2/STAT3 pathway

(2018) Lingyan Yuan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

Hypertension, Left Ventricular Hypertrophy, and Myocardial Ischemia

(2017) Tony Stanton et al.   MEDICAL CLINICS OF NORTH AMERICA

Bioinformatics analysis of key genes and signaling pathways associated with myocardial infarction following telomerase activation

(2017) Yi Yang et al.   Molecular Medicine Reports

Short Telomere Length and Ischemic Heart Disease: Observational and Genetic Studies in 290 022 Individuals

(2016) A. Scheller Madrid et al.   CLINICAL CHEMISTRY

Coronary Physiology Assessment for the Diagnosis and Treatment of Stable Ischemic Heart Disease

(2016) Ali E. Denktas et al.   Current Atherosclerosis Reports

Telomere shortening and telomerase activity in ischaemic cardiomyopathy patients – Potential markers of ventricular arrhythmia

(2016) V. Sawhney et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Dose response of dexmedetomidine-induced resistance to hypoxia in mice

(2016) Wanying Pan et al.   Molecular Medicine Reports

ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2

(2016) Vincent Picco et al.   Oncotarget

Telomeres and Telomerase in Cardiovascular Diseases

(2016) Jih-Kai Yeh et al.   Genes

5-Aminolevulinic acid combined with sodium ferrous citrate ameliorates H2O2-induced cardiomyocyte hypertrophy via activation of the MAPK/Nrf2/HO-1 pathway

(2015) Mingyi Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

An overview of the efficacy of resveratrol in the management of ischemic heart disease

(2015) Pema Raj et al.   Annals of the New York Academy of Sciences

Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway

(2015) Peng Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protective Effects of 7-Hydroxycoumarin on Dyslipidemia and Cardiac Hypertrophy in Isoproterenol-Induced Myocardial Infarction in Rats

(2015) Govindan Sangaran Jagadeesh et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Acute myocardial infarction: ‘telomerasing’ for cardioprotection

(2015) Fabian Sanchis-Gomar et al.   TRENDS IN MOLECULAR MEDICINE

Protective effects of dexmedetomidine on intestinal ischemia-reperfusion injury

(2015) YONG SUN et al.   Experimental and Therapeutic Medicine

Angiogenesis and Cardiac Hypertrophy

(2014) Toru Oka et al.   CIRCULATION RESEARCH

Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy

(2014) S Gallo et al.   Cell Death & Disease

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction

(2014) Christian Bär et al.   Nature Communications

Repetitive hyperthermia attenuates progression of left ventricular hypertrophy and increases telomerase activity in hypertensive rats

(2012) Jun-ichi Oyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart

(2012) Mauricio Ibacache et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Telomeres—structure, function, and regulation

(2012) Weisi Lu et al.   EXPERIMENTAL CELL RESEARCH

A derivative of the CRMP2 binding compound lanthionine ketimine provides neuroprotection in a mouse model of cerebral ischemia

(2012) Shadia E. Nada et al.   NEUROCHEMISTRY INTERNATIONAL

Telomerase: Structure, functions, and activity regulation

(2011) M. I. Zvereva et al.   BIOCHEMISTRY-MOSCOW

Gene therapy for ischemic heart disease

(2011) Rabea Hinkel et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Cellular mechanisms of cardiomyopathy

(2011) Pamela A. Harvey et al.   JOURNAL OF CELL BIOLOGY

Danshen–Gegen decoction protects against hypoxia/reoxygenation-induced apoptosis by inhibiting mitochondrial permeability transition via the redox-sensitive ERK/Nrf2 and PKCɛ/mKATP pathways in H9c2 cardiomyocytes

(2011) Po Yee Chiu et al.   PHYTOMEDICINE

Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells

(2010) Po Yee Chiu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY