Gene therapy for ischemic heart disease

A randomised, double-blind, placebo-controlled, multicentre study of the safety and efficacy of BIOBYPASS (AdGVVEGF121.10NH) gene therapy in patients with refractory advanced coronary artery disease: the NOVA trial

(2011) Jens Kastrup et al.   EuroIntervention

“Locked onto the Target”: Increasing the Efficiency of Antagomirzymes Using Locked Nucleic Acid Modifications

(2010) Harleen Kaur et al.   BIOCHEMISTRY

Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization

(2010) A. N. Stratman et al.   BLOOD

Cardiac-targeted delivery of regulatory RNA molecules and genes for the treatment of heart failure

(2010) W. Poller et al.   CARDIOVASCULAR RESEARCH

MicroRNAs Add a New Dimension to Cardiovascular Disease

(2010) Eric M. Small et al.   CIRCULATION

Myocardial Transfection of Hypoxia Inducible Factor-1α via an Adenoviral Vector During Coronary Artery Bypass Grafting

(2010) Eckehard Gerd Kilian et al.   CIRCULATION JOURNAL

Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution

(2010) K-M R Prasad et al.   GENE THERAPY

Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice

(2010) David M. Patrick et al.   JOURNAL OF CLINICAL INVESTIGATION

Nonviral Intercellular Adhesion Molecule-1 Small Interfering Ribonucleic Acid Sequences Transfection In Vivo

(2010) Christian Kupatt   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cotransfection of Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Via Recombinant Adeno-Associated Virus Resolves Chronic Ischemic Malperfusion

(2010) Christian Kupatt et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

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(2010) Jennifer Ziello et al.   MOLECULAR MEDICINE

Delivery of Gene and Cellular Therapies for Heart Disease

(2010) Justin A. Mariani et al.   Journal of Cardiovascular Translational Research

Midkine gene transfer after myocardial infarction in rats prevents remodelling and ameliorates cardiac dysfunction

(2009) Arihiro Sumida et al.   CARDIOVASCULAR RESEARCH

MicroRNA-320 Is Involved in the Regulation of Cardiac Ischemia/Reperfusion Injury by Targeting Heat-Shock Protein 20

(2009) Xiao-Ping Ren et al.   CIRCULATION

Reciprocal Regulation of MicroRNA-1 and Insulin-Like Growth Factor-1 Signal Transduction Cascade in Cardiac and Skeletal Muscle in Physiological and Pathological Conditions

(2009) Leonardo Elia et al.   CIRCULATION

Heart Disease and Stroke Statistics—2010 Update

(2009) et al.   CIRCULATION

Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes

(2009) Shweta Rane et al.   CIRCULATION RESEARCH

Loss of Cardiac microRNA-Mediated Regulation Leads to Dilated Cardiomyopathy and Heart Failure

(2009) Prakash K. Rao et al.   CIRCULATION RESEARCH

Stimulation of collateral artery growth: travelling further down the road to clinical application

(2009) S H Schirmer et al.   HEART

Cardiac Gene Therapy: Optimization of Gene Delivery Techniques In Vivo

(2009) Michael G. Katz et al.   HUMAN GENE THERAPY

Preventing and exploiting the oncogenic potential of integrating gene vectors

(2009) Ute Modlich et al.   JOURNAL OF CLINICAL INVESTIGATION

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

(2009) Eugenio Montini et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice

(2009) Thomas E. Callis et al.   JOURNAL OF CLINICAL INVESTIGATION

VEGF Gene Therapy Fails to Improve Perfusion of Ischemic Myocardium in Patients With Advanced Coronary Disease: Results of the NORTHERN Trial

(2009) Duncan J Stewart et al.   MOLECULAR THERAPY

Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle

(2009) Aravind Asokan et al.   NATURE BIOTECHNOLOGY

A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection

(2009) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice

(2009) A. Bonauer et al.   SCIENCE

Collateral circulation

(2008) Wolfgang Schaper   BASIC RESEARCH IN CARDIOLOGY

Cardiac Dissonance Without Conductors

(2008) Thomas Thum   CIRCULATION

miR-126 Regulates Angiogenic Signaling and Vascular Integrity

(2008) Jason E. Fish et al.   DEVELOPMENTAL CELL

Release of biomarkers of myocardial damage after direct intramyocardial injection of genes and stem cells via the percutaneous transluminal route

(2008) F. Baldazzi et al.   EUROPEAN HEART JOURNAL

Hypoxia induces microRNA miR-210 in vitro and in vivo

(2008) Kati Pulkkinen et al.   FEBS LETTERS

miRNA expression in the failing human heart: Functional correlates

(2008) Carmen Sucharov et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Microbubbles as ultrasound triggered drug carriers

(2008) Steliyan Tinkov et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Acute myocardial infarction

(2008) Harvey D White et al.   LANCET

Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection

(2008) Carmela Zincarelli et al.   MOLECULAR THERAPY

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

Designing Heart Performance by Gene Transfer

(2008) Jennifer Davis et al.   PHYSIOLOGICAL REVIEWS

Causes of death in patients with acute myocardial infarction treated with angiotensin-converting enzyme inhibitors: Findings from the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto (GISSI)–3 trial

(2007) Giovanni Pedrazzini et al.   AMERICAN HEART JOURNAL

Gene therapy: targeting the myocardium

(2007) A R Lyon et al.   HEART