Article
Cardiac & Cardiovascular Systems
Jean-Baptiste Guichard, Feng Xiong, Xiao-Yan Qi, Nathalie L'Heureux, Roddy Hiram, Jiening Xiao, Patrice Naud, Jean-Claude Tardif, Antoine Da Costa, Stanley Nattel
Summary: This study assessed the specific contributions of atrial fibrillation-related atrial arrhythmia vs. associated ventricular arrhythmia to remodeling. The results showed that both atrial tachyarrhythmia and rapid ventricular response during AF produce distinct atrial remodelling, providing new insights into AF-related remodeling and ventricular rate-control considerations.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Maryam Farazandeh, Maryam Mahmoudabady, Ali Akbar Asghari, Saeed Niazmand
Summary: Cinnamon extract can prevent diabetic heart damage by alleviating cardiac inflammation and fibrosis, in addition to its hypoglycemic and antioxidant properties.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Yen-Nien Lin, Thassio Mesquita, Lizbeth Sanchez, Yin-Huei Chen, Weixin Liu, Chang Li, Russell Rogers, Yizhou Wang, Xinling Li, Di Wu, Rui Zhang, Ahmed Ibrahim, Eduardo Marban, Eugenio Cingolani
Summary: The study demonstrated that extracellular vesicles secreted by cardiosphere-derived cells exerted significant effects in improving cardiac function, reducing cardiac inflammation, and suppressing arrhythmias in an arrhythmogenic cardiomyopathy murine model.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Alwin B. P. Noordman, Alexander H. Maass, Hessel Groenveld, Bart A. Mulder, Michiel Rienstra, Yuri Blaauw
Summary: This study showed that myocardial scar characterization based on cardiac magnetic resonance imaging can improve risk stratification for ventricular arrhythmia occurrence in patients with ischemic cardiomyopathy who received an Implantable Cardioverter-Defibrillator (ICD). The analysis revealed that total scar mass and border zone mass independently predicted appropriate ICD therapy, suggesting the importance of myocardial scar assessment in determining the risk of ventricular arrhythmias in this patient population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Immunology
Qi Liu, Jun Zhu, Bin Kong, Wei Shuai, He Huang
Summary: The study revealed that tirzepatide, a dual GLP-1 and GIP receptor agonist, has a protective effect on sepsis-induced cardiac dysfunction, and its mechanism of action is through the inhibition of the TLR4/NF-kB/NLRP3 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Katharina Knoll, Patrick Fuchs, Isabel Weidmann, Fatih Altunkas, Stephanie Voss, Carsten Lennerz, Christof Kolb, Thorsten Kessler, Heribert Schunkert, Wibke Reinhard, Stefan Gross, Teresa Trenkwalder
Summary: The incidence of ventricular arrhythmias in wtATTR-CM is 44% and is associated with the severity of left ventricular disease. Further studies are needed to evaluate the role of ventricular arrhythmias in predicting sudden cardiac death and the benefit of ICD therapy in wtATTR-CM.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Yen-Nien Lin, Ahmed Ibrahim, Eduardo Marban, Eugenio Cingolani
Summary: Arrhythmogenic cardiomyopathy (AC) is a genetic disease characterized by progressive heart muscle breakdown and inflammation. Myocardial inflammation is a key feature in the early stages of the disease, and targeting inflammation has shown promise in preclinical models for slowing disease progression.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Clara Stegmann, Cosima Jahnke, Frank Lindemann, Sabrina Oebel, Sergio Richter, Andreas Bollmann, Nikolaos Dagres, Gerhard Hindricks, Ingo Paetsch
Summary: This study aimed to establish a predictive model based on CMR for distinguishing 'arrhythmia-induced' from 'arrhythmia-mediated' cardiomyopathy in patients with atrial tachyarrhythmias. Results showed that assessment of LVEDVI category and LGE by CMR allowed for effective identification of arrhythmia-induced cardiomyopathy.
Review
Genetics & Heredity
Chiara Di Resta, Jan Berg, Andrea Villatore, Marianna Maia, Gianluca Pili, Francesco Fioravanti, Rossella Tomaiuolo, Simone Sala, Sara Benedetti, Giovanni Peretto
Summary: Having a new and more precise definition of BrS may be crucial to improve the clinical management of patients, at diagnostic, prognostic, and therapeutic levels. The evidence of myocardial structural and functional abnormalities in patients with BrS challenges the definition of the disease as a channelopathy.
Article
Pharmacology & Pharmacy
Wu Luo, Gaojun Wu, Xiaojun Chen, Qiuyan Zhang, Chunpeng Zou, Jun Wang, Jun Liu, Nipon Chattipakorn, Yi Wang, Guang Liang
Summary: The expression of MyD88 protein was found to be increased in the hearts of diabetic mice. Inhibition of MyD88 through siRNA or small-molecular inhibitor markedly reduced inflammatory response and associated cell signaling pathway activation under high glucose conditions. Furthermore, pharmacological inhibition of MyD88 showed anti-inflammatory, anti-hypertrophic, and anti-fibrotic effects in diabetic mouse hearts. These findings indicate that MyD88 may serve as a potential therapeutic target for diabetic cardiomyopathy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Donah Zachariah, Kenzaburo Nakajima, Luca Rosario Limite, David Zweiker, Michael Spartalis, Davide Zirolia, Martina Musto, Giuseppe D'Angelo, Gabriele Paglino, Francesca Baratto, Manuela Cireddu, Caterina Bisceglia, Andrea Radinovic, Alessandra Marzi, Simone Sala, Giovanni Peretto, Pasquale Vergara, Simone Gulletta, Patrizio Mazzone, Paolo Della Bella
Summary: This study describes ventricular signal abnormalities in three different pathologies and examines their association with the diastolic component of VT circuits. The results show that the nature of abnormal signals in different cardiomyopathies reflects underlying pathology.
Review
Cell Biology
Christine Mages, Heike Gampp, Pascal Syren, Ann-Kathrin Rahm, Florian Andre, Norbert Frey, Patrick Lugenbiel, Dierk Thomas
Summary: This review highlights the pathomechanisms underlying arrhythmogenicity in patients with heart failure, such as myocardial fibrosis and ion channel remodeling. It emphasizes the association of dysregulated ion channel expression with cardiomyopathy and arrhythmia development, and discusses potential therapeutic options.
Article
Cardiac & Cardiovascular Systems
Roddy Hiram, Feng Xiong, Patrice Naud, Jiening Xiao, Martin Sirois, Jean-Francois Tanguay, Jean-Claude Tardif, Stanley Nattel
Summary: The study found that the inflammation-resolution enhancing molecule RvD1 can prevent atrial arrhythmogenic remodeling in experimental RHD by suppressing inflammatory signaling and fibrotic/electrical remodeling.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Alex Horby Christensen, Pyotr G. Platonov, Anneli Svensson, Henrik K. Jensen, Christine Rootwelt-Norberg, Pia Dahlberg, Trine Madsen, Tanja Charlotte Frederiksen, Tiina Helio, Kristina H. Haugaa, Henning Bundgaard, Jesper H. Svendsen
Summary: This study describes the complications associated with implantable cardioverter-defibrillators (ICD) treatment in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). The results show that during long-term follow-up, approximately 41% of patients experienced potentially life-saving ICD therapy, while 27% had complications requiring surgery, mainly lead-related complications.
Article
Oncology
Linsheng Song, Xinyi Zhao, Wenlong Lv, Jie Zeng, Yishuang Wang, Bo Gong, Andreas P. Kalogeropoulos, Hong Pu, Yifeng Bai, Shengkun Peng
Summary: This study aims to explore the value of cardiac magnetic resonance feature tracking in the diagnosis of malignant ventricular arrhythmia in patients with nonischemic dilated cardiomyopathy. The findings suggest that parameters such as global longitudinal strain and global circumferential strain can be used to predict the occurrence of malignant ventricular arrhythmia.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Xiaohong Gu, Yuechun Li, Kaixin Chen, Xingang Wang, Zhongyu Wang, Hao Lian, Yuanzheng Lin, Xing Rong, Maoping Chu, Jiafeng Lin, Xiaoling Guo
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Engineering, Civil
Yuanzheng Lin, Kaiming Bi, Zhouhong Zong, Hong Hao, Jin Lin, Yiyan Chen
JOURNAL OF BRIDGE ENGINEERING
(2020)
Article
Materials Science, Characterization & Testing
Yuanzheng Lin, Yiqian Chen, Zhouhong Zong, Jin Lin, Guangwu Tang, Xiaohui He
Summary: This study introduces a new hybrid input strategy for reproducing across-fault ground motions on multi-shaking tables, overcoming limitations of traditional acceleration and displacement input strategies. Validated through shaking table tests, the hybrid input strategy was found to provide improved fidelity in reproducing across-fault ground motions, offering useful references for structural performance investigations in earthquake scenarios.
JOURNAL OF TESTING AND EVALUATION
(2021)
Article
Engineering, Geological
Yuanzheng Lin, Zhouhong Zong, Kaiming Bi, Hong Hao, Jin Lin, Yiyan Chen
BULLETIN OF EARTHQUAKE ENGINEERING
(2020)
Article
Thermodynamics
Tianliang Lin, Yuanzheng Lin, Haoling Ren, Haibin Chen, Zhongshen Li, Qihuai Chen
Summary: This paper proposes a load sensing system based on displacement adaptive and variable speed control for electric excavator, as well as a novel control strategy based on hierarchical differential pressure control. By utilizing these methods, the control performance of the electric excavator can be effectively improved, and energy consumption can be reduced by 19%e70%.
Article
Materials Science, Ceramics
Jingming Cai, Jinlong Pan, Jinsheng Han, Yuanzheng Lin, Zhaoliang Sheng
Summary: This study investigates the low-energy impact behaviors of engineered geopolymer composite (EGC) and discusses the feasibility of developing ambient cured EGC with cheap PVA fiber. The experimental results show that EGC exhibits similar tensile behaviors with engineered cementitious composites (ECC) and has high impact-resistance. The impact behaviors of EGC and geopolymeric matrix are affected by NaOH molarity. The findings suggest the potential application of EGC.
CERAMICS INTERNATIONAL
(2022)
Article
Construction & Building Technology
Jingming Cai, Jinlong Pan, Jinsheng Han, Yuanzheng Lin, Zhaoliang Sheng
Summary: This study demonstrates that EGC exhibits superior impact resistance at high temperatures and is more suitable for impact protection of structures in high temperature environments compared to ECC.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yale Li, Zhouhong Zong, Bingwen Yang, Zhanghua Xia, Yuanzheng Lin, Jin Lin
Summary: Factors such as seismic characteristics, multi-directional seismic coupling, span, pier height, and structural system type influence the collapse resistance of continuous girder bridges. Different ground motion characteristics and design approaches can lead to varying collapse modes.
APPLIED SCIENCES-BASEL
(2021)
Article
Construction & Building Technology
Qian Li, Kaiming Bi, Huihui Dong, Yuanzheng Lin, Qiang Han, Xiuli Du
Summary: The seismic performances of different bridge structures supported by precast segmental columns are investigated and compared under various earthquake ground motions in this study. The influences of permanent ground displacement and pulse period are also examined. The results show that the permanent ground displacement has different effects on segmental columns-supported bridge and monolithic columns supported bridge.
ADVANCES IN STRUCTURAL ENGINEERING
(2022)
Article
Engineering, Geological
Guanyu Xie, Xihong Zhang, Hong Hao, Kaiming Bi, Yuanzheng Lin
Summary: This paper investigates the seismic behavior of interlocking brick walls through laboratory tests and numerical modeling. The study finds that interlocking brick walls have higher seismic resistance compared to conventional masonry walls, and their damage modes are different.
BULLETIN OF EARTHQUAKE ENGINEERING
(2022)
Article
Construction & Building Technology
Jinsheng Han, Jingming Cai, Yuanzheng Lin, Yuqin Sun, Jinlong Pan
Summary: This study aims to investigate the impact resistance of engineered geopolymer composite (EGC) in cold temperatures. The experimental results show that EGC has comparable compressive strength and tensile behavior with ECC, and also exhibits preferable impact resistance under low temperature environments.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zhongshen Li, Yuanzheng Lin, Qihuai Chen, Kai Wu, Tianliang Lin, Haoling Ren, Wen Gong
Summary: Energy conservation and emission reduction have become a global development consensus. Electric construction machinery, with its zero emissions, is considered a main trend in the future. However, the control of the motor and hydraulic systems in existing electric construction machinery can still be further optimized. A control strategy based on motor speed classification and variable constant power is proposed to adapt to the working conditions of the power system, providing a relatively stable speed input for the hydraulic system.
APPLIED SCIENCES-BASEL
(2022)
Article
Construction & Building Technology
Zongping Chen, Yuhan Liang, Yuanzheng Lin, Jingming Cai
Summary: With the development of modern transportation, the recycling and reusing of waste tires have become a global concern. This study aimed to develop impact-resistant engineered cementitious composites (ECC) using waste tire rubber as aggregate. The mechanical behaviors of rubber-modified ECC were investigated, and the impact tests were conducted under different environmental temperatures and impact heights. The results showed that rubber-modified ECC is more suitable as impact-resistant material in cold regions.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Environmental Sciences
Yuanzheng Lin, Bin Zhao, Xiujie Ma
Summary: This study investigates the impact of Guozhuang Dance on the subjective well-being of older adults. The results show that Guozhuang Dance has a positive effect on enhancing the subjective well-being of older adults and can increase their well-being through the chain mediating effect of group identity and self-efficacy.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Engineering, Civil
Yuanzheng Lin, Kaidi Xing, Zhouhong Zong, Minghong Li, Kaiming Bi, Yale Li
Summary: In this study, an innovative posttensioned precast segmental CFDST (PTPS-CFDST) column was proposed and its seismic performance was investigated through experimental tests. The results showed that the PTPS-CFDST column had good seismic performance, self-centering capacity, and minor damage. The arrangement of external energy dissipation devices and the use of high prestressing force were found to enhance the seismic performance of the column.
JOURNAL OF BRIDGE ENGINEERING
(2023)