Side effects of statins: from pathophysiology and epidemiology to diagnostic and therapeutic implications

SLCO1B1*5 Allele is Associated with Atorvastatin Discontinuation and Adverse Muscle Symptoms in the Context of Routine Care

(2022) Deepak Voora et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Prevalence of statin intolerance: a meta-analysis

(2022) Ibadete Bytyçi et al.   EUROPEAN HEART JOURNAL

Statin Use and The Incidence of Age-Related Macular Degeneration

(2022) Arshia Eshtiaghi et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Emerging views of statin pleiotropy and cholesterol lowering

(2021) Dongbo Yu et al.   CARDIOVASCULAR RESEARCH

Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials

(2021) Emily Herrett et al.   BMJ-British Medical Journal

Global epidemiology of dyslipidaemias

(2021) Angela Pirillo et al.   Nature Reviews Cardiology

Optimal use of lipid-lowering therapy after acute coronary syndromes: A Position Paper endorsed by the International Lipid Expert Panel (ILEP)

(2021) Maciej Banach et al.   PHARMACOLOGICAL RESEARCH

Association Between Vitamin D and Statin-Related Myopathy: A Meta-analysis

(2021) Qingtao Hou et al.   American Journal of Cardiovascular Drugs

Statins Are Associated With Increased Insulin Resistance and Secretion

(2021) Fahim Abbasi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Statin liver safety in non‐alcoholic fatty liver disease. A systematic review and metanalysis

(2021) Daniele Pastori et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Effect of SLCO1B1 T521C on Statin‐Related Myotoxicity With Use of Lovastatin and Atorvastatin

(2021) Brian Lu et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Nocebo/drucebo effect in statin-intolerant patients: an attempt at recommendations

(2021) Peter E Penson et al.   EUROPEAN HEART JOURNAL

Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment

(2021) James P. Howard et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of Statin Therapy on Cognitive Decline and Incident Dementia in Older Adults

(2021) Zhen Zhou et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Lipid-Lowering Therapy and Hemorrhagic Stroke Risk: Comparative Meta-Analysis of Statins and PCSK9 Inhibitors

(2021) Borja E. Sanz-Cuesta et al.   STROKE

Statin therapy and its association with long-term survival after colon cancer surgery

(2021) Arvid Pourlotfi et al.   SURGERY

Intensity of statin therapy and muscle symptoms: a network meta-analysis of 153 000 patients

(2021) John W Davis et al.   BMJ Open

Associations between statins and adverse events in primary prevention of cardiovascular disease: systematic review with pairwise, network, and dose-response meta-analyses

(2021) Ting Cai et al.   BMJ-British Medical Journal

Long-Term Statin Use, Total Cholesterol Level, and Risk of Colorectal Cancer: A Prospective Cohort Study

(2021) Yin Zhang et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Statin-Related New-Onset Diabetes Appears Driven by Increased Insulin Resistance: Are There Clinical Implications?

(2021) Eliot A. Brinton   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lipid-lowering therapy use in primary and secondary care in Central and Eastern Europe: DA VINCI observational study

(2021) Michal Vrablik et al.   ATHEROSCLEROSIS

Statins for primary prevention among elderly men and women

(2021) Maria Bergami et al.   CARDIOVASCULAR RESEARCH

Combination lipid-lowering therapy as first-line strategy in very high-risk patients

(2021) Kausik K Ray et al.   EUROPEAN HEART JOURNAL

Statin use and incidence and mortality of breast and gynecology cancer: A cohort study using the National Health Insurance claims database

(2021) Dong‐Sook Kim et al.   INTERNATIONAL JOURNAL OF CANCER

Moderate Intensity Exercise Training Improves Skeletal Muscle Performance in Symptomatic and Asymptomatic Statin Users

(2021) Neeltje A.E. Allard et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Exercise Training Improves Muscle Performance and Quality of Life in Patients With Statin Muscle Symptoms

(2021) Robert S. Rosenson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Intracranial Hemorrhage in the TST Trial

(2021) Pierre Amarenco et al.   STROKE

Exploring Pleiotropic Effects of Lipid Modifiers and Targets on Measures of the Coagulation System with Genetics

(2021) C. Mary Schooling et al.   THROMBOSIS AND HAEMOSTASIS

Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis

(2021) Madeleine Dorsch et al.   Cell Reports

Statin use and risk of dementia or Alzheimer’s disease: a systematic review and meta-analysis of observational studies

(2021) Elena Olmastroni et al.   European Journal of Preventive Cardiology

Association of Statin Therapy Initiation With Diabetes Progression

(2021) Ishak A. Mansi et al.   JAMA Internal Medicine

Common Statin Intolerance Variants in ABCB1 and LILRB5 Show Synergistic Effects on Statin Response: An Observational Study Using Electronic Health Records

(2021) Alaa’ Lutfi Melhem et al.   Frontiers in Genetics

Outcomes of Screening for Prostate Cancer Among Men Who Use Statins

(2021) Arla Vettenranta et al.   JAMA Oncology

Statin Discontinuation and Cardiovascular Events Among Older People in Denmark

(2021) Wade Thompson et al.   JAMA Network Open

Cerebrovascular Disease and Statins

(2021) Luis M. Beltrán Romero et al.   Frontiers in Cardiovascular Medicine

Statin Therapy in Very Old Patients: Lights and Shadows

(2021) Lidia Cobos-Palacios et al.   Frontiers in Cardiovascular Medicine

Statin therapy in athletes and patients performing regular intense exercise – Position Paper from the International Lipid Expert Panel (ILEP)

(2020) Niki Katsiki et al.   PHARMACOLOGICAL RESEARCH

A scoring system for predicting individual treatment effects of statins in type 2 diabetes patients on haemodialysis

(2020) Bernd Genser et al.   European Journal of Preventive Cardiology

Statins and Risk of Intracerebral Hemorrhage in Individuals With a History of Stroke

(2020) Anette Riisgaard Ribe et al.   STROKE

β Cell-Specific Deletion of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) Reductase Causes Overt Diabetes Due to Reduction of β Cell Mass and Impaired Insulin Secretion

(2020) Shoko Takei et al.   DIABETES

Independent risk factors for simvastatin-related myopathy and relevance to different types of muscle symptom

(2020) Jemma C Hopewell et al.   EUROPEAN HEART JOURNAL

An updated review of pharmacokinetic drug interactions and pharmacogenetics of statins

(2020) Takeshi Hirota et al.   Expert Opinion on Drug Metabolism & Toxicology

In-depth Mendelian randomization analysis of causal factors for coronary artery disease

(2020) Yuan-De Tan et al.   Scientific Reports

Association of Bempedoic Acid Administration With Atherogenic Lipid Levels in Phase 3 Randomized Clinical Trials of Patients With Hypercholesterolemia

(2020) Maciej Banach et al.   JAMA Cardiology

Safety and Efficacy of Pitavastatin in Patients With Impaired Fasting Glucose and Hyperlipidemia: A Randomized, Open-Labeled, Multicentered, Phase IV Study

(2020) Hae-Young Lee et al.   CLINICAL THERAPEUTICS

How low is safe? The frontier of very low (<30 mg/dL) LDL cholesterol

(2020) Angelos D Karagiannis et al.   EUROPEAN HEART JOURNAL

Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real‐life setting: the PROSISA Study

(2020) M. Casula et al.   JOURNAL OF INTERNAL MEDICINE

N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects

(2020) Frances A. Wood et al.   NEW ENGLAND JOURNAL OF MEDICINE

Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association

(2019) Connie B. Newman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Statin Toxicity

(2019) Natalie C. Ward et al.   CIRCULATION RESEARCH

Statin Use and Risk of Pancreatic Cancer

(2019) Yun Zhang et al.   PANCREAS

Effects of blood pressure and lipid lowering on cognition

(2019) Jackie Bosch et al.   NEUROLOGY

Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials

(2019) Jane Armitage et al.   LANCET

Recent advances in synthetic pharmacotherapies for dyslipidaemias

(2019) Cesare R Sirtori et al.   European Journal of Preventive Cardiology

Genomewide Association Study of Statin‐Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink

(2019) Daniel F. Carr et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Lipophilic Statins and Risk for Hepatocellular Carcinoma and Death in Patients With Chronic Viral Hepatitis: Results From a Nationwide Swedish Population

(2019) Tracey G. Simon et al.   ANNALS OF INTERNAL MEDICINE

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk

(2019) François Mach et al.   EUROPEAN HEART JOURNAL

Chemoprevention of Colorectal Cancer

(2019) Bryson W. Katona et al.   GASTROENTEROLOGY

Statin Use and the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B

(2019) Myung Ji Goh et al.   HEPATOLOGY

Levofloxacin‐induced rhabdomyolysis in a patient on concurrent atorvastatin: Case report and literature review

(2019) Jeannette Bouchard et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Willingness to be Re-initiated on a Statin (From the REasons for Geographic And Racial Differences in Stroke [REGARDS] Study)

(2018) Matthew T. Mefford et al.   AMERICAN JOURNAL OF CARDIOLOGY

Effect of pitavastatin compared with atorvastatin and rosuvastatin on new-onset diabetes mellitus in patients with acute myocardial infarction

(2018) Jah Yeon Choi et al.   AMERICAN JOURNAL OF CARDIOLOGY

High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD)

(2018) Isao Taguchi et al.   CIRCULATION

Adverse effects of statin therapy: perception vs. the evidence – focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract

(2018) François Mach et al.   EUROPEAN HEART JOURNAL

Appropriateness of statin prescription in the elderly

(2018) M. Ruscica et al.   European Journal of Internal Medicine

Clinical and pathophysiological evidence supporting the safety of extremely low LDL levels—The zero-LDL hypothesis

(2018) Luis Masana et al.   Journal of Clinical Lipidology

Risk scores to guide referral decisions for people with suspected ovarian cancer in secondary care: a systematic review and cost-effectiveness analysis

(2018) Marie Westwood et al.   HEALTH TECHNOLOGY ASSESSMENT

Impact of Lipids on Cardiovascular Health

(2018) Brian A. Ference et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Validation of a clinically-relevant rodent model of statin-associated muscle symptoms for use in pharmacological studies

(2018) Jordon Candice Irwin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Trust the Blinded Randomized Evidence That Statin Therapy Rarely Causes Symptomatic Side Effects

(2018) Richard Peto et al.   CIRCULATION

Introducing the ‘Drucebo’ effect in statin therapy: a systematic review of studies comparing reported rates of statin-associated muscle symptoms, under blinded and open-label conditions

(2018) Peter E. Penson et al.   Journal of Cachexia Sarcopenia and Muscle

A common missense variant of LILRB5 is associated with statin intolerance and myalgia

(2017) Moneeza K Siddiqui et al.   EUROPEAN HEART JOURNAL

Statin drug interactions and related adverse reactions: an update

(2017) Stefano Bellosta et al.   Expert Opinion On Drug Safety

Statins Affect Skeletal Muscle Performance: Evidence for Disturbances in Energy Metabolism

(2017) Neeltje A E Allard et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Liver Safety of Statins in Prediabetes or T2DM and Nonalcoholic Steatohepatitis: Post Hoc Analysis of a Randomized Trial

(2017) Fernando Bril et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Statin Intolerance and Risk of Coronary Heart Events and All-Cause Mortality Following Myocardial Infarction

(2017) Maria-Corina Serban et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase

(2017) Ajay Gupta et al.   LANCET

Statin Use and the Risk of Cataracts: A Systematic Review and Meta‐Analysis

(2017) Shandong Yu et al.   Journal of the American Heart Association

Risk of Myopathy in Patients in Therapy with Statins: Identification of Biological Markers in a Pilot Study

(2017) Giulia M. Camerino et al.   Frontiers in Pharmacology

Metabolic Markers to Predict Incident Diabetes Mellitus in Statin-Treated Patients (from the Treating to New Targets and the Stroke Prevention by Aggressive Reduction in Cholesterol Levels Trials)

(2016) Payal Kohli et al.   AMERICAN JOURNAL OF CARDIOLOGY

Diagnosis, Prevention, and Management of Statin Adverse Effects and Intolerance: Canadian Consensus Working Group Update (2016)

(2016) G.B. John Mancini et al.   CANADIAN JOURNAL OF CARDIOLOGY

Long-Term Effectiveness and Safety of Pravastatin in Patients With Coronary Heart DiseaseCLINICAL PERSPECTIVE

(2016) Wendy E. Hague et al.   CIRCULATION

Recommendations for Management of Clinically Significant Drug-Drug Interactions With Statins and Select Agents Used in Patients With Cardiovascular Disease: A Scientific Statement From the American Heart Association

(2016) Barbara S. Wiggins et al.   CIRCULATION

Long-Term Safety and Efficacy of Lowering Low-Density Lipoprotein Cholesterol With Statin TherapyCLINICAL PERSPECTIVE

(2016) Ian Ford et al.   CIRCULATION

Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes

(2016) Luca A. Lotta et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Interpretation of the evidence for the efficacy and safety of statin therapy

(2016) Rory Collins et al.   LANCET

Hepatotoxicity of statins and other lipid-lowering agents

(2016) Einar S. Björnsson   LIVER INTERNATIONAL

Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease

(2016) Salim Yusuf et al.   NEW ENGLAND JOURNAL OF MEDICINE

Statin-Associated Autoimmune Myopathy

(2016) Andrew L. Mammen   NEW ENGLAND JOURNAL OF MEDICINE

High Dose Atorvastatin Associated with Increased Risk of Significant Hepatotoxicity in Comparison to Simvastatin in UK GPRD Cohort

(2016) Alan T. Clarke et al.   PLoS One

Effect of pitavastatin on glucose, HbA1c and incident diabetes: A meta-analysis of randomized controlled clinical trials in individuals without diabetes

(2015) Antonio J. Vallejo-Vaz et al.   ATHEROSCLEROSIS

Could changes in adiponectin drive the effect of statins on the risk of new-onset diabetes? The case of pitavastatin

(2015) Lorenzo Arnaboldi et al.   ATHEROSCLEROSIS SUPPLEMENTS

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition

(2015) Tom J.J. Schirris et al.   Cell Metabolism

Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort

(2015) Henna Cederberg et al.   DIABETOLOGIA

Negative statin-related news stories decrease statin persistence and increase myocardial infarction and cardiovascular mortality: a nationwide prospective cohort study

(2015) Sune Fallgaard Nielsen et al.   EUROPEAN HEART JOURNAL

Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management

(2015) Erik S. Stroes et al.   EUROPEAN HEART JOURNAL

The role of mitochondria in statin-induced myopathy

(2015) Maria Apostolopoulou et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

(2015) Maciej Banach et al.   Expert Opinion On Drug Safety

Natural history and outcomes in drug-induced autoimmune hepatitis

(2015) Tian T. Yeong et al.   HEPATOLOGY RESEARCH

Analysis of vitamin D levels in patients with and without statin-associated myalgia — A systematic review and meta-analysis of 7 studies with 2420 patients

(2015) Marta Michalska-Kasiczak et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Do Statins Impair Cognition? A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2015) Brian R. Ott et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Risk of New-Onset Diabetes and Cardiovascular Risk Reduction From High-Dose Statin Therapy in Pre-Diabetics and Non – Pre-Diabetics

(2015) Payal Kohli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

(2015) Daniel I Swerdlow et al.   LANCET

Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials

(2015)   LANCET

Effects of Coenzyme Q10 on Statin-Induced Myopathy

(2015) Maciej Banach et al.   MAYO CLINIC PROCEEDINGS

Statins, cognition, and dementia—systematic review and methodological commentary

(2015) Melinda C. Power et al.   Nature Reviews Neurology

Statin therapy and plasma coenzyme Q10 concentrations—A systematic review and meta-analysis of placebo-controlled trials

(2015) Maciej Banach et al.   PHARMACOLOGICAL RESEARCH

Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism

(2015) Vasundhara Kain et al.   Scientific Reports

A systematic review of statin-induced muscle problems in clinical trials

(2014) Harsha V. Ganga et al.   AMERICAN HEART JOURNAL

High-potency statins increase the risk of acute kidney injury: Evidence from a large population-based study

(2014) Giovanni Corrao et al.   ATHEROSCLEROSIS

Statins, mood, sleep, and physical function: a systematic review

(2014) Kristopher J. Swiger et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Spectrum of statin hepatotoxicity: Experience of the drug-induced liver injury network

(2014) Mark W. Russo et al.   HEPATOLOGY

An assessment by the Statin Muscle Safety Task Force: 2014 update

(2014) Robert S. Rosenson et al.   Journal of Clinical Lipidology

An assessment by the Statin Intolerance Panel: 2014 update

(2014) John R. Guyton et al.   Journal of Clinical Lipidology

KDIGO Clinical Practice Guideline for Lipid Management in CKD: summary of recommendation statements and clinical approach to the patient

(2014) Christoph Wanner et al.   KIDNEY INTERNATIONAL

GATM gene variants and statin myopathy risk

(2014) D. F. Carr et al.   NATURE

Lack of association between SLCO1B1 polymorphisms and clinical myalgia following rosuvastatin therapy

(2013) Jacqueline S. Danik et al.   AMERICAN HEART JOURNAL

Relation of Statin Therapy to Psychological Functioning in Patients With an Implantable Cardioverter Defibrillator

(2013) Madelein T. Hoogwegt et al.   AMERICAN JOURNAL OF CARDIOLOGY

Meta-Analysis of Impact of Different Types and Doses of Statins on New-Onset Diabetes Mellitus

(2013) Eliano Pio Navarese et al.   AMERICAN JOURNAL OF CARDIOLOGY

Discontinuation of Statins in Routine Care Settings

(2013) Huabing Zhang et al.   ANNALS OF INTERNAL MEDICINE

Long-term use of statins reduces the risk of hospitalization for dementia

(2013) Giovanni Corrao et al.   ATHEROSCLEROSIS

Comparative Tolerability and Harms of Individual Statins

(2013) Huseyin Naci et al.  

SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink

(2013) D F Carr et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Statin Therapy and New-onset Diabetes: Molecular Mechanisms and Clinical Relevance

(2013) Maciej Banach et al.   CURRENT PHARMACEUTICAL DESIGN

HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment

(2013) et al.   EUROPEAN HEART JOURNAL

Incidence, Presentation, and Outcomes in Patients With Drug-Induced Liver Injury in the General Population of Iceland

(2013) Einar S. Björnsson et al.   GASTROENTEROLOGY

A meta-analysis of the role of statins on renal outcomes in patients with chronic kidney disease. Is the duration of therapy important?

(2013) Dragana Nikolic et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Predictors of statin adherence, switching, and discontinuation in the USAGE survey: Understanding the use of statins in America and gaps in patient education

(2013) Melissa Y. Wei et al.   Journal of Clinical Lipidology

A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

(2013) Lara M. Mangravite et al.   NATURE

Statins decrease all-cause mortality only in CKD patients not requiring dialysis therapy—A meta-analysis of 11 randomized controlled trials involving 21,295 participants

(2013) Marcin Barylski et al.   PHARMACOLOGICAL RESEARCH

Psychologic Disorders and Statin Use: A Propensity Score-Matched Analysis

(2013) Ishak Mansi et al.   PHARMACOTHERAPY

Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases

(2013) C. R. Dormuth et al.   BMJ-British Medical Journal

Risk of incident diabetes among patients treated with statins: population based study

(2013) A. A. Carter et al.   BMJ-British Medical Journal

Association of Statin Use With Cataracts

(2013) Jessica Leuschen et al.   JAMA Ophthalmology

Proportion and Risk Indicators of Nonadherence to Statin Therapy: A Meta-analysis

(2012) Mark Lemstra et al.   CANADIAN JOURNAL OF CARDIOLOGY

Effect of Statins on Skeletal Muscle Function

(2012) Beth A. Parker et al.   CIRCULATION

Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial

(2012) Paul M Ridker et al.   LANCET

Discontinuation of statin therapy due to muscular side effects: A survey in real life

(2012) D. Rosenbaum et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Statin Therapy and the Risk of Intracerebral Hemorrhage

(2012) James S. McKinney et al.   STROKE

The Anglo-Scandinavian Cardiac Outcomes Trial: 11-year mortality follow-up of the lipid-lowering arm in the UK

(2011) Peter S. Sever et al.   EUROPEAN HEART JOURNAL

Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy

(2011) David Preiss   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Predictors of New-Onset Diabetes in Patients Treated With Atorvastatin

(2011) David D. Waters et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin

(2011) L R Brunham et al.   PHARMACOGENOMICS JOURNAL

Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study

(2010) Adrian Reuben et al.   HEPATOLOGY

Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study

(2010) Martin J O'Donnell et al.   LANCET

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials

(2010) Naveed Sattar et al.   LANCET

Statins and fenofibrate affect skeletal muscle chloride conductance in rats by differently impairing ClC-1 channel regulation and expression

(2009) S Pierno et al.   BRITISH JOURNAL OF PHARMACOLOGY

Association between statin-associated myopathy and skeletal muscle damage

(2009) M. G. Mohaupt et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

3-hydroxy 3-methylglutaryl coenzyme A reductase increase is essential for rat muscle differentiation

(2009) Chiara Martini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pravastatin and cognitive function in the elderly. Results of the PROSPER study

(2009) Stella Trompet et al.   JOURNAL OF NEUROLOGY

The SLCO1B1*5Genetic Variant Is Associated With Statin-Induced Side Effects

(2009) Deepak Voora et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Statin-Associated Adverse Cognitive Effects: Survey Results from 171 Patients

(2009) Marcella A Evans et al.   PHARMACOTHERAPY

Drug-Induced Liver Injury Associated with Statins

(2009) Mark Russo et al.   SEMINARS IN LIVER DISEASE

The safety and tolerability of atorvastatin 10 mg in the Collaborative Atorvastatin Diabetes Study (CARDS)

(2008) Connie B Newman et al.   Diabetes & Vascular Disease Research

Atorvastatin in Factorial with Omega-3 EE90 Risk Reduction in Diabetes (AFORRD): a randomised controlled trial

(2008) R. R. Holman et al.   DIABETOLOGIA

Statin-Associated Psychiatric Adverse Events

(2008) Marco Tuccori et al.   DRUG SAFETY

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cells

(2007) Karin Mausner-Fainberg et al.   ATHEROSCLEROSIS