Statin use and risk of dementia or Alzheimer’s disease: a systematic review and meta-analysis of observational studies

Global epidemiology of dyslipidaemias

(2021) Angela Pirillo et al.   Nature Reviews Cardiology

Hydrophilic or Lipophilic Statins?

(2021) Elisenda Climent et al.   Frontiers in Cardiovascular Medicine

Statin exposure and the risk of dementia in individuals with hypercholesterolaemia

(2020) J.‐W. Lee et al.   JOURNAL OF INTERNAL MEDICINE

Telmisartan and Rosuvastatin Synergistically Ameliorate Dementia and Cognitive Impairment in Older Hypertensive Patients With Apolipoprotein E Genotype

(2020) Wenjing Hu et al.   Frontiers in Aging Neuroscience

Risk of dementia in patients with periodontitis and related protective factors: a nationwide retrospective cohort study

(2020) Chia‐Yen Lee et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Association Between Low-Density Lipoprotein Cholesterol Levels, Statin Use, and Dementia in Patients followed in German General Practices

(2020) Rebecca Zingel et al.   JOURNAL OF ALZHEIMERS DISEASE

Statins, lipids and dementia?

(2020) Lewis H. Kuller   Journal of Clinical Lipidology

Effects of blood pressure and lipid lowering on cognition

(2019) Jackie Bosch et al.   NEUROLOGY

Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials

(2019) Jane Armitage et al.   LANCET

Association Between Statin Use and Risk of Dementia After a Concussion

(2019) Donald A. Redelmeier et al.   JAMA Neurology

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk

(2019) François Mach et al.   EUROPEAN HEART JOURNAL

High exposure to statins decrease the risk of new-onset dementia

(2019) Chih-Feng Chang et al.   MEDICINE

Lipid lowering and Alzheimer disease risk: A mendelian randomization study

(2019) Dylan M. Williams et al.   ANNALS OF NEUROLOGY

The effect of high-dose atorvastatin on neural activity and cognitive function

(2018) Beth A. Taylor et al.   AMERICAN HEART JOURNAL

Adverse effects of statin therapy: perception vs. the evidence – focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract

(2018) François Mach et al.   EUROPEAN HEART JOURNAL

Antihypertensive drugs and relevant cardiovascular pharmacotherapies and the risk of incident dementia in patients with atrial fibrillation

(2018) Per Wändell et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Use of statins and the risk of dementia and mild cognitive impairment: A systematic review and meta-analysis

(2018) Che-Sheng Chu et al.   Scientific Reports

Lipid Lowering Agents, Cognitive Decline, and Dementia: The Three-City Study

(2018) Marie-Laure Ancelin et al.   JOURNAL OF ALZHEIMERS DISEASE

Conversion of Mild Cognitive Impairment to Dementia among Subjects with Diabetes: A Population-Based Study of Incidence and Risk Factors with Five Years of Follow-up

(2018) Fei Ma et al.   JOURNAL OF ALZHEIMERS DISEASE

Statin Use and the Risk of Dementia in Patients with Stroke: A Nationwide Population-Based Cohort Study

(2018) Mei-Lien Pan et al.   Journal of Stroke & Cerebrovascular Diseases

Statins use and risk of dementia

(2018) Xiaoyu Zhang et al.   MEDICINE

Statin reduces the risk of dementia in diabetic patients receiving androgen deprivation therapy for prostate cancer

(2018) Jui-Ming Liu et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Cognitive Function in a Randomized Trial of Evolocumab

(2017) Robert P. Giugliano et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low LDL cholesterol,PCSK9andHMGCRgenetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study

(2017) Marianne Benn et al.   BMJ-British Medical Journal

Low LDL cholesterol,PCSK9andHMGCRgenetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study

(2017) Marianne Benn et al.   BMJ-British Medical Journal

Statins and the Brain: More than Lipid Lowering Agents?

(2017) Anna Fracassi et al.   Current Neuropharmacology

Risk factors for dementia diagnosis in German primary care practices

(2016) Anke Booker et al.   INTERNATIONAL PSYCHOGERIATRICS

Use of Statins and Risk of Dementia in Heart Failure: A Retrospective Cohort Study

(2015) Abhishek S. Chitnis et al.   DRUGS & AGING

Statin Use, Incident Dementia and Alzheimer Disease in Elderly African Americans

(2015) Hugh C. Hendrie et al.   ETHNICITY & DISEASE

Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management

(2015) Erik S. Stroes et al.   EUROPEAN HEART JOURNAL

Statins and the risk of dementia in patients with atrial fibrillation: A nationwide population-based cohort study

(2015) Tze-Fan Chao et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Do Statins Impair Cognition? A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2015) Brian R. Ott et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials

(2015)   LANCET

Early Statin Use and the Progression of Alzheimer Disease

(2015) Feng-Cheng Lin et al.   MEDICINE

Statins, cognition, and dementia—systematic review and methodological commentary

(2015) Melinda C. Power et al.   Nature Reviews Neurology

Statins Reduces the Risk of Dementia in Patients with Late-Onset Depression: A Retrospective Cohort Study

(2015) Ya-Hsu Yang et al.   PLoS One

Decreased prevalence of dementia associated with statins: a national population-based study

(2014) C.-S. Chuang et al.   EUROPEAN JOURNAL OF NEUROLOGY

Statin use and incident dementia: A nationwide cohort study of Taiwan

(2014) Chian-Ying Chou et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Long-Term Statin Use and Dementia Risk in Taiwan

(2014) Ping-Yen Chen et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Statin use reduces the risk of dementia in elderly patients: a nationwide data survey and propensity analysis

(2014) C.-K. Wu et al.   JOURNAL OF INTERNAL MEDICINE

Effects of Statins on Incident Dementia in Patients with Type 2 DM: A Population-Based Retrospective Cohort Study in Taiwan

(2014) Jui-Ming Chen et al.   PLoS One

Long-term use of statins reduces the risk of hospitalization for dementia

(2013) Giovanni Corrao et al.   ATHEROSCLEROSIS

Long-Term Effects of Secondary Prevention on Cognitive Function in Stroke Patients

(2013) Abdel Douiri et al.   CIRCULATION

The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

(2013)   LANCET

Statins and Cognition: A Systematic Review and Meta-analysis of Short- and Long-term Cognitive Effects

(2013) Kristopher J. Swiger et al.   MAYO CLINIC PROCEEDINGS

Healthy User and Related Biases in Observational Studies of Preventive Interventions: A Primer for Physicians

(2011) William H. Shrank et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Statins, Risk of Dementia, and Cognitive Function: Secondary Analysis of the Ginkgo Evaluation of Memory Study

(2011) Kerstin Bettermann et al.   Journal of Stroke & Cerebrovascular Diseases

Risk factors for dementia in patients over 65 with diabetes

(2010) Niraj M. Parikh et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Statins and serum cholesterol's associations with incident dementia and mild cognitive impairment

(2010) M. A. Beydoun et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Age-Varying Association Between Statin Use and Incident Alzheimer's Disease

(2010) Ge Li et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Increased Atherogenic Lipoproteins are Associated With Cognitive Impairment

(2009) Cynthia M. Carlsson et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Pravastatin and cognitive function in the elderly. Results of the PROSPER study

(2009) Stella Trompet et al.   JOURNAL OF NEUROLOGY

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2009) David Moher et al.   PLOS MEDICINE

Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trials

(2008) Liam Smeeth et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Reduced Risk of Incident AD with Elective Statin Use in a Clinical Trial Cohort

(2008) D. Sparks et al.   Current Alzheimer Research

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study

(2008) M D M Haag et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Statins, incident Alzheimer disease, change in cognitive function, and neuropathology

(2008) Z. Arvanitakis et al.   NEUROLOGY

Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study

(2008) C. Cramer et al.   NEUROLOGY