Research progress of active ingredients of Scutellaria baicalensis in the treatment of type 2 diabetes and its complications

Baicalin suppresses renal fibrosis through microRNA-124/TLR4/NF-κB axis in streptozotocin-induced diabetic nephropathy mice and high glucose-treated human proximal tubule epithelial cells

(2020) Shefeng Zhang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Structural Dependence of Sulfated Polysaccharide for Diabetes Management: Fucoidan From Undaria pinnatifida Inhibiting α-Glucosidase More Strongly Than α-Amylase and Amyloglucosidase

(2020) Hui Si Audrey Koh et al.   Frontiers in Pharmacology

The inhibitory effects of flavonoids on α-amylase and α-glucosidase

(2019) Jianzhong Zhu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Antidiabetic Potential of Flavonoids from Traditional Chinese Medicine: A Review

(2019) Lan Bai et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Baicalin ameliorates lipopolysaccharide-induced acute lung injury in mice by suppressing oxidative stress and inflammation via the activation of the Nrf2-mediated HO-1 signaling pathway

(2019) Xiangli Meng et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Knockdown of ANGPTL-4 inhibits inflammatory response and extracellular matrix accumulation in glomerular mesangial cells cultured under high glucose condition

(2019) Linfang Qin et al.   Artificial Cells Nanomedicine and Biotechnology

Baicalin relieves hypoxia-aroused H9c2 cell apoptosis by activating Nrf2/HO-1-mediated HIF1α/BNIP3 pathway

(2019) Hailiang Yu et al.   Artificial Cells Nanomedicine and Biotechnology

Considerations when using alpha-glucosidase inhibitors in the treatment of type 2 diabetes

(2019) Maka S. Hedrington et al.   EXPERT OPINION ON PHARMACOTHERAPY

SP1‐mediated lncRNA PVT1 modulates the proliferation and apoptosis of lens epithelial cells in diabetic cataract via miR‐214‐3p/MMP2 axis

(2019) Jun Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Baicalin ameliorates hepatic insulin resistance and gluconeogenic activity through inhibition of p38 MAPK/PGC-1α pathway

(2019) Penghua Fang et al.   PHYTOMEDICINE

HMGB1 Mediates Paraquat-Induced Neuroinflammatory Responses via Activating RAGE Signaling Pathway

(2019) Min Huang et al.   NEUROTOXICITY RESEARCH

A strategy to improve the oral availability of baicalein: The baicalein-theophylline cocrystal

(2018) Wen Li et al.   FITOTERAPIA

A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism

(2018) Naoko Niimi et al.   JOURNAL OF NEUROCHEMISTRY

Role of Caspase-3-Mediated Apoptosis in Chronic Caspase-3-Cleaved Tau Accumulation and Blood–Brain Barrier Damage in the Corpus Callosum after Traumatic Brain Injury in Rats

(2018) Olena Y. Glushakova et al.   JOURNAL OF NEUROTRAUMA

Myocardial Interstitial Fibrosis in Heart Failure

(2018) Arantxa González et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cellular and molecular mechanisms of kidney fibrosis

(2018) Sonja Djudjaj et al.   MOLECULAR ASPECTS OF MEDICINE

Starfish Apaf-1 activates effector caspase-3/9 upon apoptosis of aged eggs

(2018) Ritsuko Tamura et al.   Scientific Reports

Identification of baicalin from Bofutsushosan and Daisaikoto as a potent inducer of glucose uptake and modulator of insulin signaling-associated pathways

(2018) Yu-Ting Kuo et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway

(2018) Jiang Fang et al.   Drug Design Development and Therapy

Targeting inflammation in diabetic nephropathy: a tale of hope

(2018) Juan Antonio Moreno et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Circulating S100A8/A9 Levels Reflect Intraocular Inflammation in Uveitis Patients

(2018) Yu-Qin Wang et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2

(2018) Peng Xu et al.   Frontiers in Pharmacology

Baicalin and chrysin mixture imparts cyto-protection against methylglyoxal induced cytotoxicity and diabetic tubular injury by modulating RAGE, oxidative stress and inflammation

(2017) Jyotsna Singh et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

MiR-34a contributes to diabetes-related cochlear hair cell apoptosis via SIRT1/HIF-1α signaling

(2017) Ying Lin et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes

(2017) Aidin Rawshani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Involvement of Nrf2 in Ocular Diseases

(2017) Shehzad Batliwala et al.   Oxidative Medicine and Cellular Longevity

Baicalein protects rat insulinoma INS-1 cells from palmitate-induced lipotoxicity by inducing HO-1

(2017) Hyun Jeong Kwak et al.   PLoS One

Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria by decreasing ANGPTL-4 expression

(2017) Lingyu Xue et al.   BMC Nephrology

Association of single-nucleotide polymorphisms in the RAGE gene and its gene- environment interactions with diabetic nephropathy in Chinese patients with type 2 diabetes

(2017) Ying Zhang et al.   Oncotarget

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers

(2016) Hongxian Pang et al.   CLINICAL DRUG INVESTIGATION

Tackling myocardial ischemic injury: the signal transducer and activator of transcription 3 (STAT3) at a good site

(2016) Yang Yang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Baicalein alleviates doxorubicin-induced cardiotoxicity via suppression of myocardial oxidative stress and apoptosis in mice

(2016) Bidya Dhar Sahu et al.   LIFE SCIENCES

Inhibition of JNK suppresses autophagy and attenuates insulin resistance in a rat model of nonalcoholic fatty liver disease

(2016) Hua Yan et al.   Molecular Medicine Reports

Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype

(2016) Xianli Shen et al.   NATURE IMMUNOLOGY

Epalrestat protects against diabetic peripheral neuropathy by alleviating oxidative stress and inhibiting polyol pathway

(2016) Hong-ying Yang et al.   Neural Regeneration Research

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

(2016) Frederick E. Dewey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combination of Sitagliptin and Insulin against Type 2 Diabetes Mellitus with Neuropathy in Rats: Neuroprotection and Role of Oxidative and Inflammation Stress

(2016) Mohamed Elsayed Kelany et al.   PHARMACOLOGY

Hypoxic Conditioned Medium From Human Adipose-Derived Stem Cells Promotes Mouse Liver Regeneration Through JAK/STAT3 Signaling

(2016) Sang Chul Lee et al.   Stem Cells Translational Medicine

Az oxidatív stressz szerepe a diabeteses neuropathia kialakulásában

(2016) Ferenc Sztanek et al.   ORVOSI HETILAP

Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation

(2015) Yang Sun et al.   BIOCHEMICAL PHARMACOLOGY

Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-κB and STAT Signaling Pathways in Diabetic Mice

(2015) Iolanda Lazaro et al.   DIABETES

The contribution of NF-κB signalling to immune regulation and tolerance

(2015) Myrthe A. M. van Delft et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Baicalin Inhibits Lipopolysaccharide-Induced Inflammation Through Signaling NF-κB Pathway in HBE16 Airway Epithelial Cells

(2015) Shou-jin Dong et al.   INFLAMMATION

The protective effect of baicalin against renal ischemia-reperfusion injury through inhibition of inflammation and apoptosis

(2014) Miao Lin et al.   BMC Complementary and Alternative Medicine

The Four Faces of Autophagy: Implications for Cancer Therapy

(2014) D. A. Gewirtz   CANCER RESEARCH

Old, new and emerging functions of caspases

(2014) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

Arachidonate 12/15-Lipoxygenase–Induced Inflammation and Oxidative Stress Are Involved in the Development of Diabetic Cardiomyopathy

(2014) Hirofumi Suzuki et al.   DIABETES

Wogonoside Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2014) Liang Zhang et al.   INFLAMMATION

The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-κB pathway activation

(2014) Li Cui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

TAK1-ECSIT-TRAF6 Complex Plays a Key Role in the TLR4 Signal to Activate NF-κB

(2014) Sae Mi Wi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects

(2014) Min Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Synthesis of Ring A-Modified Baicalein Derivatives

(2011) Jun-Fei Wang et al.   HELVETICA CHIMICA ACTA

Ocular pharmacokinetic study on baicalin in lens of rabbits following intragastric administration

(2009) Jia Zhiyan et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Increased Oral AUC of Baicalin in Streptozotocin-Induced Diabetic Rats due to the Increased Activity of Intestinal β-Glucuronidase

(2009) Li Liu et al.   PLANTA MEDICA

Coronary effluent from a preconditioned heart activates the JAK-STAT pathway and induces cardioprotection in a donor heart

(2007) Lynn C. Huffman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY