Journal
ORVOSI HETILAP
Volume 157, Issue 49, Pages 1939-1946Publisher
AKADEMIAI KIADO ZRT
DOI: 10.1556/650.2016.30609
Keywords
diabetic neuropathy; oxidative stress; inflammation; endothelial dysfunction; microvascular complications
Categories
Ask authors/readers for more resources
Diabetic neuropathy may be one of the most common and severe complications of diabetes mellitus. Oxidative stress plays a pivotal role in the development of microvascular complications of diabetes. The majority of related pathways like polyol and hexosamine, advanced glycation end products, poly-ADP-ribose polymerase, and protein kinase-C all originated from initial oxidative stress. In this review, the authors present the current oxidative stress hypothesis in diabetes mellitus and summarize the pathophysiological mechanisms of diabetic neuropathy associated with increased oxidative stress. The development of modern medicines to treat diabetic neuropathy needs intensive long-term comparative trials in the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available