Trehalose protects against cisplatin-induced cochlear hair cell damage by activating TFEB-mediated autophagy

Molecular mechanisms of action of Trehalose in cancer: A comprehensive review

(2021) Nyshadham S N Chaitanya et al.   LIFE SCIENCES

U0126 pretreatment inhibits cisplatin-induced apoptosis and autophagy in HEI-OC1 cells and cochlear hair cells

(2021) Dan Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pseudoginsenoside F11 ameliorates the dysfunction of the autophagy-lysosomal pathway by activating calcineurin-mediated TFEB nuclear translocation in neuron during permanent cerebral ischemia

(2021) Xiaoxiao Fu et al.   EXPERIMENTAL NEUROLOGY

Cisplatin-induced ototoxicity: Updates on molecular mechanisms and otoprotective strategies

(2021) Qing Tang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Autophagy: A Novel Horizon for Hair Cell Protection

(2021) Chang Liu et al.   NEURAL PLASTICITY

Autophagy in Cisplatin Nephrotoxicity during Cancer Therapy

(2021) Xiaoru Hu et al.   Cancers

Clinical trials evaluating transtympanic otoprotectants for cisplatin-induced ototoxicity: what do we know so far?

(2020) Sofia Waissbluth   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Trehalose in Machado-Joseph Disease: Safety, Tolerability, and Efficacy

(2020) Roy Zaltzman et al.   CEREBELLUM

Cisplatin-Induced Stria Vascularis Damage Is Associated with Inflammation and Fibrosis

(2020) Na Zhang et al.   NEURAL PLASTICITY

Sirtuin 1 and Autophagy Attenuate Cisplatin-Induced Hair Cell Death in the Mouse Cochlea and Zebrafish Lateral Line

(2019) Jiaqi Pang et al.   Frontiers in Cellular Neuroscience

The Antioxidative Role of Autophagy in Hearing Loss

(2019) Bin Ye et al.   Frontiers in Neuroscience

Necroptosis and apoptosis contribute to cisplatin and aminoglycoside ototoxicity

(2019) Douglas Ruhl et al.   JOURNAL OF NEUROSCIENCE

Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR

(2019) Bin Ye et al.   Autophagy

Cisplatin-Induced Ototoxicity: Updates on Molecular Targets

(2019) Erica Gentilin et al.   TRENDS IN MOLECULAR MEDICINE

Trehalose promotes the survival of random-pattern skin flaps by TFEB mediated autophagy enhancement

(2019) Hongqiang Wu et al.   Cell Death & Disease

Activation of TFEB ameliorates dedifferentiation of arterial smooth muscle cells and neointima formation in mice with high-fat diet

(2019) Yun-Ting Wang et al.   Cell Death & Disease

Pou4f3 gene mutation promotes autophagy and apoptosis of cochlear hair cells in cisplatin-induced deafness mice

(2019) Feilong Xu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Oral trehalose maybe helpful for patients with spinocerebellar ataxia 3 and should be better evaluated

(2019) M.A. Noorasyikin et al.   PARKINSONISM & RELATED DISORDERS

Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency

(2018) Parisa Lotfi et al.   Autophagy

TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis

(2018) Trent D. Evans et al.   Autophagy

PINK1 Protects Auditory Hair Cells and Spiral Ganglion Neurons from Cisplatin-induced Ototoxicity via Inducing Autophagy and Inhibiting JNK Signaling Pathway

(2018) Qianqian Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction

(2018) Sebastiano Sciarretta et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of NLRX1-mediated autophagy accelerates the ototoxic potential of cisplatin in auditory cells

(2018) Haiyan Yin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Meclofenamic Acid Reduces Reactive Oxygen Species Accumulation and Apoptosis, Inhibits Excessive Autophagy, and Protects Hair Cell-Like HEI-OC1 Cells From Cisplatin-Induced Damage

(2018) He Li et al.   Frontiers in Cellular Neuroscience

Trehalose protects against oxidative stress by regulating the Keap1–Nrf2 and autophagy pathways

(2018) Yuhei Mizunoe et al.   Redox Biology

Evaluating protective and therapeutic effects of alpha-lipoic acid on cisplatin-induced ototoxicity

(2018) Kyung-Hee Kim et al.   Cell Death & Disease

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

(2018) Paola Rusmini et al.   Autophagy

Genetic and Modifiable Risk Factors Contributing to Cisplatin-induced Toxicities

(2018) Matthew R. Trendowski et al.   CLINICAL CANCER RESEARCH

Clinical effect of intratympanic dexamethasone injection in acute unilateral tinnitus: A prospective, placebo-controlled, multicenter study

(2017) Hyun-Jin Lee et al.   LARYNGOSCOPE

Autophagy is essential for hearing in mice

(2017) Chisato Fujimoto et al.   Cell Death & Disease

Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development

(2017) Qian Tang et al.   Cell Death & Disease

mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

(2017) Michela Palmieri et al.   Nature Communications

Intratympanic methylprednisolone versus gentamicin in patients with unilateral Ménière's disease: a randomised, double-blind, comparative effectiveness trial

(2016) Mitesh Patel et al.   LANCET

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

(2016) Xiaoli Zhang et al.   Nature Communications

Autophagy Attenuates Noise-Induced Hearing Loss by Reducing Oxidative Stress

(2015) Hu Yuan et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A  Generation and Amyloid Plaque Pathogenesis

(2015) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of sensorineural cell damage, death and survival in the cochlea

(2015) Ann C. Y. Wong et al.   Frontiers in Aging Neuroscience

Rapamycin alleviates cisplatin-induced ototoxicity in vivo

(2014) Bin Fang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy

(2012) Véronique Schaeffer et al.   Autophagy

Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling

(2012) Amlan Das et al.   BIOCHEMICAL PHARMACOLOGY

Transtympanic Injections of N-acetylcysteine for the Prevention of Cisplatin-induced Ototoxicity

(2011) Maria G. Riga et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

(2011) Diego L. Medina et al.   DEVELOPMENTAL CELL

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

(2011) Ana-Maria Florea et al.   Cancers

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Roles of NADPH Oxidases in Cisplatin-Induced Reactive Oxygen Species Generation and Ototoxicity

(2010) H.-J. Kim et al.   JOURNAL OF NEUROSCIENCE