U0126 pretreatment inhibits cisplatin-induced apoptosis and autophagy in HEI-OC1 cells and cochlear hair cells
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Title
U0126 pretreatment inhibits cisplatin-induced apoptosis and autophagy in HEI-OC1 cells and cochlear hair cells
Authors
Keywords
Ototoxicity, Cisplatin, Hair cell, U0126, ERK signaling pathway
Journal
TOXICOLOGY AND APPLIED PHARMACOLOGY
Volume 415, Issue -, Pages 115447
Publisher
Elsevier BV
Online
2021-02-10
DOI
10.1016/j.taap.2021.115447
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Note: Only part of the references are listed.- Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo
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- (2020) Jie Ji et al. INTERNATIONAL IMMUNOPHARMACOLOGY
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- (2019) Robert Roskoski PHARMACOLOGICAL RESEARCH
- MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid haemorrhage in rats
- (2019) Simon T. Christensen et al. PLoS One
- MAPK Pathway Inhibitors Attenuated Hydrogen Peroxide Induced Damage in Neural Cells
- (2019) Zhenwei Fan et al. Biomed Research International
- Enhancing autophagy by down-regulating GSK-3β alleviates cisplatin-induced ototoxicity in vivo and in vitro
- (2019) Tianyi Liu et al. TOXICOLOGY LETTERS
- Predicting Hearing Loss After Radiotherapy and Cisplatin Chemotherapy in Patients With Head and Neck Cancer
- (2019) Andrew Schuette et al. JAMA Otolaryngology-Head & Neck Surgery
- Pou4f3 gene mutation promotes autophagy and apoptosis of cochlear hair cells in cisplatin-induced deafness mice
- (2019) Feilong Xu et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents
- (2019) Neife Aparecida Guinaim dos Santos et al. FOOD AND CHEMICAL TOXICOLOGY
- PINK1 Protects Auditory Hair Cells and Spiral Ganglion Neurons from Cisplatin-induced Ototoxicity via Inducing Autophagy and Inhibiting JNK Signaling Pathway
- (2018) Qianqian Yang et al. FREE RADICAL BIOLOGY AND MEDICINE
- U0126 protects hippocampal CA1 neurons against forebrain ischemia-induced apoptosis via the ERK1/2 signaling pathway and NMDA receptors
- (2018) Jianguo Li et al. NEUROLOGICAL RESEARCH
- Paeoniflorin reduces neomycin-induced ototoxicity in hair cells by suppression of reactive oxygen species generation and extracellularly regulated kinase signalization
- (2018) Xiaoyu Yu et al. TOXICOLOGY LETTERS
- Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives
- (2017) Tatjana Lazarević et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Hearing loss after platinum treatment is irreversible in noncranial irradiated childhood cancer survivors
- (2017) Eva Clemens et al. PEDIATRIC HEMATOLOGY AND ONCOLOGY
- Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection
- (2017) Sandeep Sheth et al. Frontiers in Cellular Neuroscience
- U0126 attenuates ischemia/reperfusion-induced apoptosis and autophagy in myocardium through MEK/ERK/EGR-1 pathway
- (2016) Anxing Wang et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- HEI-OC1 cells as a model for investigating drug cytotoxicity
- (2016) Gilda Kalinec et al. HEARING RESEARCH
- U0126 Protects Cells against Oxidative Stress Independent of Its Function as a MEK Inhibitor
- (2015) Qunxiang Ong et al. ACS Chemical Neuroscience
- NOX3-TARGETED THERAPIES FOR INNER EAR PATHOLOGIES
- (2015) Francis Rousset et al. CURRENT PHARMACEUTICAL DESIGN
- U0126 Attenuates Cerebral Vasoconstriction and Improves Long-Term Neurologic Outcome after Stroke in Female Rats
- (2015) Hilda Ahnstedt et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Recent Advances in Platinum (IV) Complex-Based Delivery Systems to Improve Platinum (II) Anticancer Therapy
- (2015) Xiaopeng Han et al. MEDICINAL RESEARCH REVIEWS
- An integrated view of cisplatin-induced nephrotoxicity and ototoxicity
- (2015) Takatoshi Karasawa et al. TOXICOLOGY LETTERS
- Rapamycin alleviates cisplatin-induced ototoxicity in vivo
- (2014) Bin Fang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Platinum compounds in children with cancer
- (2013) Antonio Ruggiero et al. ANTI-CANCER DRUGS
- Cisplatin-induced ototoxicity: Transporters playing a role in cisplatin toxicity
- (2013) Sofia Waissbluth et al. HEARING RESEARCH
- A combination of cilostazol and Ginkgo biloba extract protects against cisplatin-induced Cochleo-vestibular dysfunction by inhibiting the mitochondrial apoptotic and ERK pathways
- (2013) C J Tian et al. Cell Death & Disease
- Platinum-Induced Ototoxicity in Children: A Consensus Review on Mechanisms, Predisposition, and Protection, Including a New International Society of Pediatric Oncology Boston Ototoxicity Scale
- (2012) Penelope R. Brock et al. JOURNAL OF CLINICAL ONCOLOGY
- Beclin 1-independent autophagy contributes to apoptosis in cortical neurons
- (2011) Yulia Grishchuk et al. Autophagy
- Autophagic activity in cortical neurons under acute oxidative stress directly contributes to cell death
- (2011) Gavin C. Higgins et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Epicatechin protects the auditory organ by attenuating cisplatin-induced ototoxicity through inhibition of ERK
- (2010) J.S. Lee et al. TOXICOLOGY LETTERS
- The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death
- (2008) Francesco Cecconi et al. DEVELOPMENTAL CELL
- Evidence that Cisplatin-induced Auditory Damage is Attenuated by Downregulation of Pro-inflammatory Cytokines Via Nrf2/HO-1
- (2008) HongSeob So et al. JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
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