Metformin alleviates the depression-like behaviors of elderly apoE4 mice via improving glucose metabolism and mitochondrial biogenesis

Late-life depression and increased risk of dementia: a longitudinal cohort study

(2021) M. Ly et al.   Translational Psychiatry

Metformin reduces oxandrolone- induced depression-like behavior in rats via modulating the expression of IL-1β, IL-6, IL-10 and TNF-α

(2021) Alaa M. Hammad et al.   BEHAVIOURAL BRAIN RESEARCH

APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline

(2021) Wenting Fang et al.   Translational Psychiatry

APOE alters glucose flux through central carbon pathways in astrocytes

(2020) Holden C. Williams et al.   NEUROBIOLOGY OF DISEASE

Effects of metformin on lipopolysaccharide-induced depressive-like behavior in mice and its mechanisms

(2020) Sheng Yang et al.   NEUROREPORT

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

(2020) Leena P. Bharath et al.   Cell Metabolism

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

(2020) Gill Livingston et al.   LANCET

Antidiabetes Agents and Incident Depression: A Nationwide Population-Based Study

(2020) Lars Vedel Kessing et al.   DIABETES CARE

Metformin improves depressive-like symptoms in mice via inhibition of peripheral and central NF-κB-NLRP3 inflammation activation

(2020) Ren-Wei Du et al.   EXPERIMENTAL BRAIN RESEARCH

Metformin treatment improves the spatial memory of the aged mice in an APOE genotype–dependent manner

(2019) Jing Zhang et al.   FASEB JOURNAL

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

Risk factors for depression in elderly diabetic patients and the effect of metformin on the condition

(2019) Fenqin Chen et al.   BMC PUBLIC HEALTH

Mechanisms and treatment of late-life depression

(2019) George S. Alexopoulos   Translational Psychiatry

Metformin as Anti-Aging Therapy: Is It for Everyone?

(2019) Alexander A. Soukas et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation

(2019) Wenting Fang et al.   JOURNAL OF AFFECTIVE DISORDERS

Age-Related Hearing Loss and Its Association with Depression in Later Life

(2018) Katharine K. Brewster et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention

(2018) Long Wu et al.   JOURNAL OF NEUROSCIENCE

Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines

(2018) Malgorzata Tyszka-Czochara et al.   Nutrients

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

(2018) Josh Allen et al.   Frontiers in Neuroscience

Possible role of GLP-1 in antidepressant effects of metformin and exercise in CUMS mice

(2018) Weina Liu et al.   JOURNAL OF AFFECTIVE DISORDERS

Metformin ameliorates hypoxia/reoxygenation-induced cardiomyocyte apoptosis based on the SIRT3 signaling pathway

(2017) Yanyan Du et al.   GENE

Differential effects of metformin on age related comorbidities in older men with type 2 diabetes

(2017) Chen-Pin Wang et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Altered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E ɛ4 Carriers

(2016) Michelle Perkins et al.   JOURNAL OF ALZHEIMERS DISEASE

Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice

(2016) Lan-yan Lin et al.   Molecular Neurodegeneration

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

(2016) Yuta Katayama et al.   NATURE

A 9-Year Prospective Population-Based Study on the Association Between the APOE*E4 Allele and Late-Life Depression in Sweden

(2015) Ingmar Skoog et al.   BIOLOGICAL PSYCHIATRY

Association of Age at Depression Onset with Cognitive Functioning in Individuals with Late-Life Depression and Executive Dysfunction

(2014) R. Scott Mackin et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Imbalanced hippocampal functional networks associated with remitted geriatric depression and apolipoprotein E ε4 allele in nondemented elderly: A preliminary study

(2014) Hao Shu et al.   JOURNAL OF AFFECTIVE DISORDERS

Gene-Behavior Interaction of Depressive Symptoms and the Apolipoprotein E [Latin Small Letter Open E]4 Allele on Cognitive Decline

(2014) Kumar B. Rajan et al.   PSYCHOSOMATIC MEDICINE

Treatment Course With Antidepressant Therapy in Late-Life Depression

(2013) Yvette I. Sheline et al.   AMERICAN JOURNAL OF PSYCHIATRY

Astrocyte-derived ATP modulates depressive-like behaviors

(2013) Xiong Cao et al.   NATURE MEDICINE

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Cerebrovascular Effects of Apolipoprotein E

(2013) Berislav V. Zlokovic   JAMA Neurology

ApoE4 and late onset depression in Indian population

(2012) R. Sureshkumar et al.   JOURNAL OF AFFECTIVE DISORDERS

Apolipoprotein E, Not Fibrillar  -Amyloid, Reduces Cerebral Glucose Metabolism in Normal Aging

(2012) W. J. Jagust et al.   JOURNAL OF NEUROSCIENCE

Posterior Cingulate Glucose Metabolism, Hippocampal Glucose Metabolism, and Hippocampal Volume in Cognitively Normal, Late-Middle-Aged Persons at 3 Levels of Genetic Risk for Alzheimer Disease

(2012) Hillary D. Protas et al.   JAMA Neurology

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

APOE E4 status predicts age-related cognitive decline in the ninth decade: longitudinal follow-up of the Lothian Birth Cohort 1921

(2011) O J G Schiepers et al.   MOLECULAR PSYCHIATRY

Synergistic associations of depression and apolipoprotein E genotype with incidence of dementia

(2010) Jae-Min Kim et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain

(2010) Yu Gong et al.   NEUROSCIENCE LETTERS

Depressive Symptoms Moderate the Influence of the ApolipoproteinE ɛ4 Allele on Cognitive Decline in a Sample of Community Dwelling Older Adults

(2009) Elizabeth A. Corsentino et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Depression in Older Adults

(2009) Amy Fiske et al.   Annual Review of Clinical Psychology

A meta-analysis of depression severity and cognitive function

(2009) Lisa M. McDermott et al.   JOURNAL OF AFFECTIVE DISORDERS

The effects of apolipoprotein E on non-impaired cognitive functioning: A meta-analysis

(2009) Nick M. Wisdom et al.   NEUROBIOLOGY OF AGING

Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression

(2008) Gislaine T. Rezin et al.   NEUROCHEMISTRY INTERNATIONAL

APOE related hippocampal shape alteration in geriatric depression

(2008) Anqi Qiu et al.   NEUROIMAGE

Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function

(2008) Richard C. Scarpulla   PHYSIOLOGICAL REVIEWS