AAV‐mediated expression of secreted and transmembrane αKlotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice

Klotho, PTSD, and advanced epigenetic age in cortical tissue

(2020) Erika J. Wolf et al.   NEUROPSYCHOPHARMACOLOGY

Aged Mouse Cortical Microglia Display an Activation Profile Suggesting Immunotolerogenic Functions

(2018) Tanja Zöller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lentivirus-mediated klotho up-regulation improves aging-related memory deficits and oxidative stress in senescence-accelerated mouse prone-8 mice

(2018) Hong-Jing Zhou et al.   LIFE SCIENCES

Age-Dependent Increment of Hydroxymethylation in the Brain Cortex in the Triple-Transgenic Mouse Model of Alzheimer's Disease

(2018) Carla Cadena-del-Castillo et al.   JOURNAL OF ALZHEIMERS DISEASE

α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling

(2018) Gaozhi Chen et al.   NATURE

Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse Model

(2018) Christian Griñán-Ferré et al.   Frontiers in Cellular Neuroscience

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Secreted αKlotho isoform protects against age-dependent memory deficits

(2017) A Massó et al.   MOLECULAR PSYCHIATRY

SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions

(2017) Ichiro Akiguchi et al.   NEUROPATHOLOGY

Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice

(2017) Julio Leon et al.   Cell Reports

Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders

(2017) Raúl Delgado-Morales et al.   Clinical Epigenetics

Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice

(2017) Wenjun Lin et al.   Scientific Reports

Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease

(2016) Danielle S. Davies et al.   BRAIN PATHOLOGY

Environmental Enrichment Modified Epigenetic Mechanisms in SAMP8 Mouse Hippocampus by Reducing Oxidative Stress and Inflammaging and Achieving Neuroprotection

(2016) Christian Griñan-Ferré et al.   Frontiers in Aging Neuroscience

Bone micro-fragility caused by the mimetic aging processes in α-klotho deficient mice: In situ nanoindentation assessment of dilatational bands

(2015) Noriko Maruyama et al.   BIOMATERIALS

Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

(2015) D. B. Dubal et al.   JOURNAL OF NEUROSCIENCE

Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression

(2015) Anna Massó et al.   PLoS One

Histone Acetylation Modifiers in the Pathogenesis of Alzheimer’s Disease

(2015) Xi Lu et al.   Frontiers in Cellular Neuroscience

Development of a Rapid, Robust, and Universal PicoGreen-Based Method to Titer Adeno-Associated Vectors

(2015) Jose Piedra et al.   Human Gene Therapy Methods

Identification of Cleavage Sites Leading to the Shed Form of the Anti-Aging Protein Klotho

(2014) Ci-Di Chen et al.   BIOCHEMISTRY

Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus

(2014) Hasan Irier et al.   GENOMICS

Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse

(2014) Daniel J. Schuster et al.   Frontiers in Neuroanatomy

Altered distribution of bone matrix proteins and defective bone mineralization in klotho-deficient mice

(2013) Muneteru Sasaki et al.   BONE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

(2013) Natacha Coppieters et al.   NEUROBIOLOGY OF AGING

Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease

(2013) Richard D. Semba et al.   NEUROSCIENCE LETTERS

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

(2011) Gwendalyn D. King et al.   AGE

Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)536 Phosphorylation

(2011) Y. Zhao et al.   DIABETES

Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons

(2010) Yi-Qun Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Site-specific bone loss in senescence-accelerated mouse (SAMP6): A murine model for senile osteoporosis

(2009) Huayue Chen et al.   EXPERIMENTAL GERONTOLOGY