Promise of irisin to attenuate cognitive dysfunction in aging and Alzheimer’s disease

Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus

(2021) Maheedhar Kodali et al.   AGING CELL

Selective Ablation of BDNF from Microglia Reveals Novel Roles in Self-Renewal and Hippocampal Neurogenesis

(2021) Samuel B. R. Harley et al.   JOURNAL OF NEUROSCIENCE

BDNF haploinsufficiency induces behavioral endophenotypes of schizophrenia in male mice that are rescued by enriched environment

(2021) Mahmoud Harb et al.   Translational Psychiatry

Moderate, intermittent voluntary exercise in a model of Gulf War Illness improves cognitive and mood function with alleviation of activated microglia and astrocytes, and enhanced neurogenesis in the hippocampus

(2021) Maheedhar Kodali et al.   BRAIN BEHAVIOR AND IMMUNITY

Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice

(2020) Yan Liu et al.   Journal of Neuroinflammation

Treadmill Exercise Attenuates Aβ-Induced Mitochondrial Dysfunction and Enhances Mitophagy Activity in APP/PS1 Transgenic Mice

(2020) Na Zhao et al.   NEUROCHEMICAL RESEARCH

FNDC5/Irisin: A New Protagonist in Acute Brain Injury

(2020) Tianqi Tu et al.   STEM CELLS AND DEVELOPMENT

Cellular senescence and Alzheimer disease: the egg and the chicken scenario

(2020) Sara Saez-Atienzar et al.   NATURE REVIEWS NEUROSCIENCE

Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

(2020) Ying-Wooi Wan et al.   Cell Reports

The involvement of NLRP3 inflammasome in the treatment of Alzheimer’s disease

(2020) Ya-Shuo Feng et al.   AGEING RESEARCH REVIEWS

Mitochondrial Damage and the Road to Exhaustion

(2020) Wenhui Li et al.   Cell Metabolism

Irisin receptor in osteocytes identified

(2019) Claire Greenhill   Nature Reviews Endocrinology

Re-evaluating Circuit Mechanisms Underlying Pattern Separation

(2019) N. Alex Cayco-Gajic et al.   NEURON

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

The prion-like propagation hypothesis in Alzheimerʼs and Parkinsonʼs disease

(2019) Charles Duyckaerts et al.   CURRENT OPINION IN NEUROLOGY

Effects of physical activity and exercise on the cognitive function of patients with Alzheimer disease: a meta-analysis

(2019) Rui-xia Jia et al.   BMC Geriatrics

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

(2019) Rik van der Kant et al.   NATURE REVIEWS NEUROSCIENCE

Adult neurogenesis and the dentate gyrus: Predicting function from form

(2019) Kimberly M. Christian et al.   BEHAVIOURAL BRAIN RESEARCH

Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice

(2019) Liping Xu et al.   NEUROBIOLOGY OF DISEASE

Cognitive symptoms of Alzheimer’s disease: clinical management and prevention

(2019) Elizabeth Joe et al.   BMJ-British Medical Journal

Anti-senescence compounds: A potential nutraceutical approach to healthy aging

(2018) Felicia Gurău et al.   AGEING RESEARCH REVIEWS

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

(2018) Xian Xia et al.   AGING CELL

FNDC5 attenuates adipose tissue inflammation and insulin resistance via AMPK-mediated macrophage polarization in obesity

(2018) Xiao-Qing Xiong et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1β-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons

(2018) YiLong Dong et al.   BMC NEUROSCIENCE

Irisin Exerts Neuroprotective Effects on Cultured Neurons by Regulating Astrocytes

(2018) Kexin Wang et al.   MEDIATORS OF INFLAMMATION

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Exercise-induced brain-derived neurotrophic factor expression: Therapeutic implications for Alzheimer’s dementia

(2018) Rosy Wang et al.   AGEING RESEARCH REVIEWS

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

(2018) Hyeonwoo Kim et al.   CELL

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

(2018) Mychael V. Lourenco et al.   NATURE MEDICINE

The Role of Irisin in Alzheimer’s Disease

(2018) Oh Kim et al.   Journal of Clinical Medicine

Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation

(2017) Agnieszka Irena Mazur-Bialy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The effects of aging in the hippocampus and cognitive decline

(2017) Luis E.B. Bettio et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Business of Anti-Aging Science

(2017) João Pedro de Magalhães et al.   TRENDS IN BIOTECHNOLOGY

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

(2017) Xiao-fei He et al.   Frontiers in Molecular Neuroscience

Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial

(2017) Jill K. Morris et al.   PLoS One

Regulation of cyclic AMP response element-binding protein during neuroglial interactions

(2016) LiMei Qin et al.   JOURNAL OF NEUROCHEMISTRY

Voluntary Running Exercise-Mediated Enhanced Neurogenesis Does Not Obliterate Retrograde Spatial Memory

(2016) M. Kodali et al.   JOURNAL OF NEUROSCIENCE

Swimming exercise increases serum irisin level and reduces body fat mass in high-fat-diet fed Wistar rats

(2016) Yun Lu et al.   Lipids in Health and Disease

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits

(2016) Kathleen M. McAvoy et al.   NEURON

Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways

(2016) Xiaoyong Qiao et al.   Scientific Reports

ERK1/2 is a key regulator of Fndc5 and PGC1α expression during neural differentiation of mESCs

(2015) S.S. Hosseini Farahabadi et al.   NEUROSCIENCE

Neuroinflammation in the normal aging hippocampus

(2015) R.M. Barrientos et al.   NEUROSCIENCE

Resveratrol Prevents Age-Related Memory and Mood Dysfunction with Increased Hippocampal Neurogenesis and Microvasculature and Reduced Glial Activation

(2015) Maheedhar Kodali et al.   Scientific Reports

Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance

(2014) María Arias-Loste et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mice with altered BDNF signaling as models for mood disorders and antidepressant effects

(2014) Jesse S. O. Lindholm et al.   Frontiers in Behavioral Neuroscience

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

(2013) Y. Zhang et al.   DIABETES

Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines

(2013) Hyun-Seuk Moon et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

(2012) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells

(2012) M.-S. Hashemi et al.   NEUROSCIENCE

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

(2009) M. E. Greenberg et al.   JOURNAL OF NEUROSCIENCE

Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis

(2009) D Taliaz et al.   MOLECULAR PSYCHIATRY

Status epilepticus during old age is not associated with enhanced hippocampal neurogenesis

(2008) Muddanna S. Rao et al.   HIPPOCAMPUS

Selective Loss of Brain-Derived Neurotrophic Factor in the Dentate Gyrus Attenuates Antidepressant Efficacy

(2007) Megumi Adachi et al.   BIOLOGICAL PSYCHIATRY

Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus

(2006) Bharathi Hattiangady et al.   NEUROBIOLOGY OF AGING