Reduced Efficiency of DNA Repair and Antioxidant Defense Promotes the Accumulation of DNA Damage during Cell Senescence

DNA damage—how and why we age?

(2021) Matt Yousefzadeh et al.   eLife

“All-In-One” Genetic Tool Assessing Endometrial Receptivity for Personalized Screening of Female Sex Steroid Hormones

(2021) Pavel Deryabin et al.   Frontiers in Cell and Developmental Biology

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy‐Related Bone Loss

(2020) Abhishek Chandra et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up

(2020) Xia Li et al.   eLife

Cell Senescence, DNA Damage, and Metabolism

(2020) Riva Shmulevich et al.   ANTIOXIDANTS & REDOX SIGNALING

Cellular senescence promotes skin carcinogenesis through p38MAPK and p44/p42MAPK signaling

(2020) Fatouma Alimirah et al.   CANCER RESEARCH

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

Role of immune cells in the removal of deleterious senescent cells

(2020) Abhijit Kale et al.   Immunity & Ageing

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

(2019) Larissa G.P. Langhi Prata et al.   SEMINARS IN IMMUNOLOGY

Molecular basis of senescence transmitting in the population of human endometrial stromal cells

(2019) Anastasiia Griukova et al.   Aging-US

Flow cytometric HyPer-based assay for hydrogen peroxide

(2018) O.G. Lyublinskaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence

(2018) Guillaume Collin et al.   Cell Death & Disease

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability

(2018) Héloïse Coutelier et al.   GENES & DEVELOPMENT

Tocotrienol-Rich Fraction Ameliorates Antioxidant Defense Mechanisms and Improves Replicative Senescence-Associated Oxidative Stress in Human Myoblasts

(2017) Shy Cian Khor et al.   Oxidative Medicine and Cellular Longevity

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

(2017) Viktor I. Korolchuk et al.   EBioMedicine

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

(2016) Pierpaola Davalli et al.   Oxidative Medicine and Cellular Longevity

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

(2016) Joe Nassour et al.   Nature Communications

Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

(2016) Aleksandra Borodkina et al.   Aging-US

Endogenous ROS levels are increased in replicative senescence in human bone marrow mesenchymal stromal cells

(2015) Sin-Gu Jeong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence

(2015) Maja Sedic et al.   Nature Communications

Senescent cells: SASPected drivers of age-related pathologies

(2014) Yossi Ovadya et al.   BIOGERONTOLOGY

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

(2014) Yi Zhu et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up

(2013) Julien Vignard et al.   RADIOTHERAPY AND ONCOLOGY

Oxidatively induced DNA damage: Mechanisms, repair and disease

(2012) Miral Dizdaroglu   CANCER LETTERS

Modeling the Rate of Senescence: Can Estimated Biological Age Predict Mortality More Accurately Than Chronological Age?

(2012) M. E. Levine   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence

(2012) Z. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen Peroxide Probes Directed to Different Cellular Compartments

(2011) Mikalai Malinouski et al.   PLoS One

Delayed kinetics of DNA double-strand break processing in normal and pathological aging

(2009) Olga A. Sedelnikova et al.   AGING CELL

Expression ofp16INK4ain peripheral blood T-cells is a biomarker of human aging

(2009) Yan Liu et al.   AGING CELL

Senescence-Associated Oxidative DNA Damage Promotes the Generation of Neoplastic Cells

(2009) K. Gosselin et al.   CANCER RESEARCH

Hydrogen peroxide induces DNA single- and double-strand breaks in thyroid cells and is therefore a potential mutagen for this organ

(2009) Natacha Driessens et al.   ENDOCRINE-RELATED CANCER

Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cells

(2009) Tongrong He et al.   MICROVASCULAR RESEARCH

Free radicals and senescence

(2008) Teng Lu et al.   EXPERIMENTAL CELL RESEARCH