DNA damage—how and why we age?

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

(2020) Matthew J. Yousefzadeh et al.   AGING CELL

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy‐Related Bone Loss

(2020) Abhishek Chandra et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications

(2020) Nathan Basisty et al.   Expert Review of Proteomics

Cellular senescence promotes skin carcinogenesis through p38MAPK and p44/p42MAPK signaling

(2020) Fatouma Alimirah et al.   CANCER RESEARCH

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

(2019) Xiao Tian et al.   CELL

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Naked mole rat cells display more efficient excision repair than mouse cells

(2018) Alexei Evdokimov et al.   Aging-US

Cardiovascular Disease in Survivors of Childhood Cancer: Insights Into Epidemiology, Pathophysiology, and Prevention

(2018) Saro H. Armenian et al.   JOURNAL OF CLINICAL ONCOLOGY

Frailty and Multimorbidity: A Systematic Review and Meta-analysis

(2018) Davide L Vetrano et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Fifty years since DNA repair was linked to cancer

(2018) Richard D. Wood   NATURE

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

(2018) Minxian Qian et al.   eLife

Genomic instability and DNA replication defects in progeroid syndromes

(2018) Romina Burla et al.   Nucleus

Genomic instability and DNA replication defects in progeroid syndromes

(2018) Romina Burla et al.   Nucleus

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

(2018) Andria R. Robinson et al.   Redox Biology

Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species

(2017) Xiao Tian et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Biomarkers to identify and isolate senescent cells

(2016) Mantas Matjusaitis et al.   AGEING RESEARCH REVIEWS

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Anticipating the "Silver Tsunami": Prevalence Trajectories and Comorbidity Burden among Older Cancer Survivors in the United States

(2016) S. M. Bluethmann et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

(2016) Evandro Fei Fang et al.   Cell Metabolism

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Influence of calorie reduction on DNA repair capacity of human peripheral blood mononuclear cells

(2016) Katja Matt et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

(2016) W. P. Vermeij et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

(2016) Aharon Helman et al.   NATURE MEDICINE

The Fanconi anaemia pathway: new players and new functions

(2016) Raphael Ceccaldi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ataxia telangiectasia: a review

(2016) Cynthia Rothblum-Oviatt et al.   Orphanet Journal of Rare Diseases

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

(2016) N. Tasdemir et al.   Cancer Discovery

The effect of six months of elastic band resistance training, nutritional supplementation or cognitive training on chromosomal damage in institutionalized elderly

(2015) Bernhard Franzke et al.   EXPERIMENTAL GERONTOLOGY

The Cockayne Syndrome Natural History (CoSyNH) study: clinical findings in 102 individuals and recommendations for care

(2015) Brian T. Wilson et al.   GENETICS IN MEDICINE

Super DNAging—New insights into DNA integrity, genome stability and telomeres in the oldest old

(2015) Bernhard Franzke et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The core spliceosome as target and effector of non-canonical ATM signalling

(2015) Maria Tresini et al.   NATURE

Forty Years of Research on Xeroderma Pigmentosum at the US National Institutes of Health

(2015) Kenneth H. Kraemer et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Barrier-to-Autointegration Factor (BAF) involvement in prelamin A-related chromatin organization changes

(2015) Manuela Loi et al.   Oncotarget

Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes

(2015) Mikhail Shaposhnikov et al.   Scientific Reports

Insights into the Evolution of Longevity from the Bowhead Whale Genome

(2015) Michael Keane et al.   Cell Reports

Helicases and human diseases

(2015) Fumiaki Uchiumi et al.   Frontiers in Genetics

Frailty in childhood cancer survivors

(2014) Kirsten K. Ness et al.   CANCER

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

(2014) Morten Scheibye-Knudsen et al.   Cell Metabolism

Somatic mutations, genome mosaicism, cancer and aging

(2014) Jan Vijg   CURRENT OPINION IN GENETICS & DEVELOPMENT

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

DNA repair diseases: what do they tell us about cancer and aging?

(2014) Carlos FM Menck et al.   GENETICS AND MOLECULAR BIOLOGY

Temporally distinct roles of ATM and ROS in genotoxic-stress-dependent induction and maintenance of cellular senescence

(2014) R. R. Nair et al.   JOURNAL OF CELL SCIENCE

Aging and Risk of Severe, Disabling, Life-Threatening, and Fatal Events in the Childhood Cancer Survivor Study

(2014) Gregory T. Armstrong et al.   JOURNAL OF CLINICAL ONCOLOGY

Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer

(2014) Hanna K. Sanoff et al.   JNCI-Journal of the National Cancer Institute

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features

(2014) Davor Lessel et al.   NATURE GENETICS

Life gained, years lost?

(2014) David Killock   Nature Reviews Clinical Oncology

Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs

(2014) Giang Huong Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1

(2013) Gabriele De Luca et al.   AGING CELL

Impact of Treatment Exposures on Cardiovascular Risk and Insulin Resistance in Childhood Cancer Survivors

(2013) K. S. Baker et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

A cascade leading to premature aging phenotypes including abnormal tumor profiles in Werner syndrome (Review)

(2013) MASANOBU SUGIMOTO   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy

(2013) Michael N Weedon et al.   NATURE GENETICS

Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair

(2013) C. Clauson et al.   Cold Spring Harbor Perspectives in Biology

Nucleotide Excision Repair in Eukaryotes

(2013) O. D. Scharer   Cold Spring Harbor Perspectives in Biology

The oxidative DNA lesions 8,5′-cyclopurines accumulate with aging in a tissue-specific manner

(2012) Jin Wang et al.   AGING CELL

Complex Cisplatin-Double Strand Break (DSB) Lesions Directly Impair Cellular Non-Homologous End-Joining (NHEJ) Independent of Downstream Damage Response (DDR) Pathways

(2012) Catherine R. Sears et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy

(2012) Morten Scheibye-Knudsen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography

(2012) Larry H. Thompson   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The p53 network: cellular and systemic DNA damage responses in aging and cancer

(2012) H. Christian Reinhardt et al.   TRENDS IN GENETICS

RECQL4 in genomic instability and aging

(2012) Deborah L. Croteau et al.   TRENDS IN GENETICS

Néstor-Guillermo progeria syndrome: A novel premature aging condition with early onset and chronic development caused by BANF1 mutations

(2011) Rubén Cabanillas et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Mitochondrial dysfunction in ataxia-telangiectasia

(2011) Y. A. Valentin-Vega et al.   BLOOD

RECQL4, the Protein Mutated in Rothmund-Thomson Syndrome, Functions in Telomere Maintenance

(2011) Avik K. Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Xeroderma pigmentosum

(2011) Alan R Lehmann et al.   Orphanet Journal of Rare Diseases

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Mechanism of p53 stabilization by ATM after DNA damage

(2010) Qian Cheng et al.   CELL CYCLE

Nuclear initiated NF-κB signaling: NEMO and ATM take center stage

(2010) Shigeki Miyamoto   CELL RESEARCH

Quantitative assessment of markers for cell senescence

(2010) Conor Lawless et al.   EXPERIMENTAL GERONTOLOGY

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

Expression ofp16INK4ain peripheral blood T-cells is a biomarker of human aging

(2009) Yan Liu et al.   AGING CELL

p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC

(2009) N R Christoffersen et al.   CELL DEATH AND DIFFERENTIATION

Methusaleh's Zoo: How Nature provides us with Clues for Extending Human Health Span

(2009) S.N. Austad   JOURNAL OF COMPARATIVE PATHOLOGY

XPF-ERCC1 Participates in the Fanconi Anemia Pathway of Cross-Link Repair

(2009) N. Bhagwat et al.   MOLECULAR AND CELLULAR BIOLOGY

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

The 8,5′-cyclopurine-2′-deoxynucleosides: Candidate neurodegenerative DNA lesions in xeroderma pigmentosum, and unique probes of transcription and nucleotide excision repair

(2008) P.J. Brooks   DNA REPAIR

ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair

(2008) A. Ahmad et al.   MOLECULAR AND CELLULAR BIOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration

(2008) Gabriele De Luca et al.   PLoS Genetics