Newly discovered endocrine functions of the liver

Down-regulation of betatrophin enhances insulin sensitivity in type 2 diabetes mellitus through activation of the GSK-3β/PGC-1α signaling pathway

(2021) Q. Hao et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Integrated Metabolomics and Lipidomics Analysis Reveal Remodeling of Lipid Metabolism and Amino Acid Metabolism in Glucagon Receptor–Deficient Zebrafish

(2021) Xuanxuan Bai et al.   Frontiers in Cell and Developmental Biology

Fetuin-A in Metabolic syndrome: A systematic review and meta-analysis

(2020) Xiongfeng Pan et al.   PLoS One

Alanine, arginine, cysteine, and proline but not glutamine are substrates for and acute mediators of the liver-alpha cell axis in female mice

(2020) Katrine D. Galsgaard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic risk factors and incident advanced liver disease in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of population-based observational studies

(2020) Helen Jarvis et al.   PLOS MEDICINE

Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH

(2020) Gianluca Svegliati-Baroni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic

(2020) Leiluo Geng et al.   Nature Reviews Endocrinology

Elevated Serum Tsukushi Levels in Patients With Hyperthyroidism

(2020) Deying Liu et al.   Frontiers in Endocrinology

Hepatokines and metabolism: Deciphering communication from the liver

(2020) Sharon O. Jensen-Cody et al.   Molecular Metabolism

Circulating Angiopoiet in-like 8 protein (ANGPTL8/Betatrophin) in patients with polycystic ovary syndrome: a systematic review and multi effect size meta-analysis

(2019) Seshadri Reddy Varikasuvu et al.   GYNECOLOGICAL ENDOCRINOLOGY

Effects of exercise training on Fetuin-a in obese, type 2 diabetes and cardiovascular disease in adults and elderly: a systematic review and Meta-analysis

(2019) Robinson Ramírez-Vélez et al.   Lipids in Health and Disease

The liver-alpha cell axis and type 2 diabetes

(2019) Nicolai J Wewer Albrechtsen et al.   ENDOCRINE REVIEWS

Endocrine Diseases and the Liver

(2019) Miguel Malespin et al.   Clinics in Liver Disease

Phosphorylation status of fetuin-A is critical for inhibition of insulin action and is correlated with obesity and insulin resistance

(2019) Guang Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The liver as an endocrine organ - linking NAFLD and insulin resistance

(2019) Matthew J Watt et al.   ENDOCRINE REVIEWS

FGF21 as Modulator of Metabolism in Health and Disease

(2019) Caterina Tezze et al.   Frontiers in Physiology

Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review

(2019) Lina Schiffer et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Deiodinases and their intricate role in thyroid hormone homeostasis

(2019) Cristina Luongo et al.   Nature Reviews Endocrinology

Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges

(2019) Úrsula Martínez-Garza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Primary Role for Alpha Cells as Amino Acid Sensors

(2019) E. Danielle Dean   DIABETES

The Relationship between Circulating ANGPTL8/Betatrophin Concentrations and Adult Obesity: A Meta-Analysis

(2019) Jingjing Ye et al.   DISEASE MARKERS

Pathways of hepatic and renal damage through non‐classical activation of the renin‐angiotensin system in chronic liver disease

(2019) Giovanni Sansoè et al.   LIVER INTERNATIONAL

Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review

(2019) Lynda Bourebaba et al.   Journal of Clinical Medicine

The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis

(2019) Mathilde Mouchiroud et al.   Molecular Metabolism

Hypercalcemia in glucagon cell hyperplasia and neoplasia (Mahvash syndrome): a new association

(2018) Matti L Gild et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

40 YEARS of IGF1: Understanding the tissue-specific roles of IGF1/IGF1R in regulating metabolism using the Cre/loxP system

(2018) Rhonda D Kineman et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mahvash Disease

(2018) Run Yu   PANCREAS

Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples

(2018) Masakazu Sugiyama et al.   PLoS One

Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat

(2018) Huating Li et al.   Nature Communications

Renin-angiotensin-aldosterone system in cirrhosis: There’s room to try!

(2018) Marco Di Pascoli et al.   DIGESTIVE AND LIVER DISEASE

Glycoprotein Non-Metastatic Protein B: An Emerging Biomarker for Lysosomal Dysfunction in Macrophages

(2018) Martijn van der Lienden et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine

(2018) Osamu Hashimoto et al.   Cell Reports

Fibroblast Growth Factor 21—Metabolic Role in Mice and Men

(2017) Harald Staiger et al.   ENDOCRINE REVIEWS

Investigational glucagon receptor antagonists in Phase I and II clinical trials for diabetes

(2017) André J. Scheen et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The Correlation Between Circulating Betatrophin and Insulin Resistance in General Population: A Meta-Analysis

(2017) Jinling Xu et al.   HORMONE AND METABOLIC RESEARCH

IGF-1 modulates gene expression of proteins involved in inflammation, cytoskeleton, and liver architecture

(2017) VJ Lara-Diaz et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Circulating betatrophin is associated with insulin resistance in humans: cross-sectional and interventional studies in vivo and in vitro

(2017) Han Wang et al.   Oncotarget

Circulating Betatrophin Levels and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

(2017) Fei-Juan Kong et al.   PLoS One

Hepatic functions of GLP-1 and its based drugs: current disputes and perspectives

(2016) Tianru Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

Upregulation of rat liver PPARα-FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol

(2016) Luis A. Videla et al.   BIOFACTORS

The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-Analysis

(2016) Song Yue et al.   DISEASE MARKERS

TSH/IGF-1 Receptor Cross Talk in Graves' Ophthalmopathy Pathogenesis

(2016) Christine C. Krieger et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Altered Concentrations in Dyslipidemia Evidence a Role for ANGPTL8/Betatrophin in Lipid Metabolism in Humans

(2016) Javier Gómez-Ambrosi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Plasma steroid-binding proteins: primary gatekeepers of steroid hormone action

(2016) Geoffrey L Hammond   JOURNAL OF ENDOCRINOLOGY

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

(2016) Sylvia Christakos et al.   PHYSIOLOGICAL REVIEWS

Abnormalities of Thyroid Hormone Metabolism during Systemic Illness: The Low T3 Syndrome in Different Clinical Settings

(2016) Arnaldo Moura Neto et al.   International Journal of Endocrinology

Activins and Inhibins: Roles in Development, Physiology, and Disease

(2016) Maria Namwanje et al.   Cold Spring Harbor Perspectives in Biology

mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes

(2016) Annabel Y. Minard et al.   Cell Reports

Osteoporosis in liver disease: pathogenesis and management

(2016) Gabriela Handzlik-Orlik et al.   Therapeutic Advances in Endocrinology and Metabolism

Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy

(2016) Aaron R. Cox et al.   PLoS One

Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice

(2015) Aaron R. Cox et al.   DIABETOLOGIA

In vivo targeted delivery of ANGPTL8 gene for beta cell regeneration in rats

(2015) Jiaxi Chen et al.   DIABETOLOGIA

 miR-577 inhibits pancreatic β-cell function and survival by targeting fibroblast growth factor 21 (FGF-21) in pediatric diabetes

(2015) X.Y. Chen et al.   GENETICS AND MOLECULAR RESEARCH

miR-212 downregulation contributes to the protective effect of exercise against non-alcoholic fatty liver via targeting FGF-21

(2015) Junjie Xiao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

FGF21 and the late adaptive response to starvation in humans

(2015) Pouneh K. Fazeli et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish

(2015) Mingyu Li et al.   JOURNAL OF ENDOCRINOLOGY

Testosterone in men with advanced liver disease: Abnormalities and implications

(2015) Marie Sinclair et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass

(2015) Mark J. Solloway et al.   Cell Reports

Circulating Betatrophin Correlates with Triglycerides and Postprandial Glucose among Different Glucose Tolerance Statuses—A Case-Control Study

(2015) Ting Gao et al.   PLoS One

A lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase

(2015) Zhiyao Fu et al.   Scientific Reports

ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion

(2014) Viktoria Gusarova et al.   CELL

Betatrophin—Promises Fading and Lessons Learned

(2014) Klaus H. Kaestner   Cell Metabolism

The PPARα-FGF21 Hormone Axis Contributes to Metabolic Regulation by the Hepatic JNK Signaling Pathway

(2014) Santiago Vernia et al.   Cell Metabolism

Vitamin D Metabolism, Mechanism of Action, and Clinical Applications

(2014) Daniel D. Bikle   CHEMISTRY & BIOLOGY

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

Direct Inhibitory Effects of Pioglitazone on Hepatic Fetuin-A Expression

(2014) Akinobu Ochi et al.   PLoS One

RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation

(2013) Peng Yi et al.   CELL

Comparison of Total Cortisol, Free Cortisol, and Surrogate Markers of Free Cortisol in Diagnosis of Adrenal Insufficiency in Patients With Stable Cirrhosis

(2013) Giuseppe Fede et al.   Clinical Gastroenterology and Hepatology

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

(2013) K. M. Habegger et al.   DIABETES

Pancreatic α-Cell Hyperplasia: Facts and Myths

(2013) Run Yu   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Drug-Induced Liver Injury: The Role of Drug Metabolism and Transport

(2013) Alberto Corsini et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Bulking Up on Beta Cells

(2013) Philip A. Seymour et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dipeptidyl peptidase-4: A key player in chronic liver disease

(2013) Minoru Itou   WORLD JOURNAL OF GASTROENTEROLOGY

Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels

(2012) Ren Zhang   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fibroblast growth factor 21 is induced by endoplasmic reticulum stress

(2012) Frank G. Schaap et al.   BIOCHIMIE

Small leucine rich proteoglycan family regulates multiple signalling pathways in neural development and maintenance

(2012) Margaret Dellett et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Liver-Specific Disruption of the Murine Glucagon Receptor Produces  -Cell Hyperplasia: Evidence for a Circulating  -Cell Growth Factor

(2012) C. Longuet et al.   DIABETES

Liver Angiotensinogen Is the Primary Source of Renal Angiotensin II

(2012) T. Matsusaka et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Alpha cells come of age

(2012) Joel F. Habener et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

α-cell role in β-cell generation and regeneration

(2012) Joel F. Habener et al.   Islets

Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

(2011) Jianxin Yang et al.   BMC GENOMICS

Fetuin-A Regulation of Calcified Matrix Metabolism

(2011) Willi Jahnen-Dechent et al.   CIRCULATION RESEARCH

A survey of small molecule glucagon receptor antagonists from recent patents (2006 – 2010)

(2011) Dong-Ming Shen et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes

(2011) Xuan Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism

(2011) Masayuki Miyazaki   Molecular Medicine Reports

Pancreatic Neuroendocrine Tumors in Glucagon Receptor-Deficient Mice

(2011) Run Yu et al.   PLoS One

Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats

(2010) D. A. Sarruf et al.   DIABETES

Thyroid Hormone Regulates Hepatic Expression of Fibroblast Growth Factor 21 in aPPARα-dependent Manner

(2010) Andrew C. Adams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The metabolic actions of glucagon revisited

(2010) Kirk M. Habegger et al.   Nature Reviews Endocrinology

Regulation of hepatic blood flow: The hepatic arterial buffer response revisited

(2010) Christian Eipel   WORLD JOURNAL OF GASTROENTEROLOGY

Hypocaloric high-protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two pathways

(2009) Takashi Uebanso et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Liver as a Lymphoid Organ

(2009) Ian Nicholas Crispe   Annual Review of Immunology

The Role of Liver-Derived Insulin-Like Growth Factor-I

(2009) Claes Ohlsson et al.   ENDOCRINE REVIEWS

Fully Human Monoclonal Antibodies Antagonizing the Glucagon Receptor Improve Glucose Homeostasis in Mice and Monkeys

(2009) H. Yan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Homozygous P86S Mutation of the Human Glucagon Receptor Is Associated With Hyperglucagonemia, α Cell Hyperplasia, and Islet Cell Tumor

(2009) Cuiqi Zhou et al.   PANCREAS

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

(2008) Cecilia Gälman et al.   Cell Metabolism

Liver Is the Site of Splanchnic Cortisol Production in Obese Nondiabetic Humans

(2008) R. Basu et al.   DIABETES

Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans

(2008) X. Zhang et al.   DIABETES

Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes

(2008) Ivan Quesada et al.   JOURNAL OF ENDOCRINOLOGY

Nesidioblastosis and Hyperplasia of ?? Cells, Microglucagonoma, and Nonfunctioning Islet Cell Tumor of the Pancreas

(2008) Run Yu et al.   PANCREAS