A survey of small molecule glucagon receptor antagonists from recent patents (2006 – 2010)

Pathologic pancreatic endocrine cell hyperplasia

(2011) Debra Ouyang   WORLD JOURNAL OF GASTROENTEROLOGY

Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core

(2010) Dong-Ming Shen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

NMR-Based Screening of Membrane Protein Ligands

(2010) Naveena Yanamala et al.   Chemical Biology & Drug Design

Diabetes area participation analysis: a review of companies and targets described in the 2008 – 2010 patent literature

(2010) Philip A Carpino et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

SGLT2 inhibition — a novel strategy for diabetes treatment

(2010) Edward C. Chao et al.   NATURE REVIEWS DRUG DISCOVERY

Prevalence of Diabetes among Men and Women in China

(2010) Wenying Yang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Glucagon Receptor Antagonists with Thiazole Cores. A Novel Series with Superior Pharmacokinetic Properties

(2009) Peter Madsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Long-Term Inhibition of the Glucagon Receptor with a Monoclonal Antibody in Mice Causes Sustained Improvement in Glycemic Control, with Reversible  -Cell Hyperplasia and Hyperglucagonemia

(2009) W. Gu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Differential expression of glucagon and glucagon-like peptide 1 receptors in mouse pancreatic alpha and beta cells in two models of alpha cell hyperplasia

(2009) Mamdouh H. Kedees et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Homozygous P86S Mutation of the Human Glucagon Receptor Is Associated With Hyperglucagonemia, α Cell Hyperplasia, and Islet Cell Tumor

(2009) Cuiqi Zhou et al.   PANCREAS

Discovery of potent, orally active benzimidazole glucagon receptor antagonists

(2008) Ronald M. Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel Glucagon Receptor Antagonists with Improved Selectivity over the Glucose-Dependent Insulinotropic Polypeptide Receptor

(2008) János T. Kodra et al.   JOURNAL OF MEDICINAL CHEMISTRY

Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound

(2007) Bena-Marie Lue et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS