Down-regulation of betatrophin enhances insulin sensitivity in type 2 diabetes mellitus through activation of the GSK-3β/PGC-1α signaling pathway

Empagliflozin, a sodium glucose co-transporter-2 inhibitor, alleviates atrial remodeling and improves mitochondrial function in high-fat diet/streptozotocin-induced diabetic rats

(2019) Qingmiao Shao et al.   Cardiovascular Diabetology

Diabetes mellitus and Alzheimer’s disease: GSK-3β as a potential link

(2018) Ying Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Relationship between serum betatrophin levels and the first-phase of glucose-stimulated insulin secretion

(2018) Dan Liu et al.   Obesity Research & Clinical Practice

Angiopoietin-like 8 (ANGPTL8) expression is regulated by miR-143-3p in human hepatocytes

(2018) Johanna K. DiStefano   GENE

Serum betatrophin levels are increased and associated with insulin resistance in patients with polycystic ovary syndrome

(2017) Qinglan Qu et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Geniposide promotes autophagy to inhibit insulin resistance in HepG2 cells via P62/NF-κB/GLUT-4

(2017) Hongwei Jiang et al.   Molecular Medicine Reports

Insulin upregulates betatrophin expression via PI3K/Akt pathway

(2017) Puhan Lu et al.   Scientific Reports

Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome

(2016) Mohamed Abu-Farha et al.   Cardiovascular Diabetology

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1–40/42and Phospho-Tau May Abet Alzheimer Development

(2016) Mini Sajan et al.   DIABETES

ANGPTL8/betatrophin alleviates insulin resistance via the Akt-GSK3β or Akt-FoxO1 pathway in HepG2 cells

(2016) Xing Rong Guo et al.   EXPERIMENTAL CELL RESEARCH

PGC-1α, glucose metabolism and type 2 diabetes mellitus

(2016) Haijiang Wu et al.   JOURNAL OF ENDOCRINOLOGY

Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance

(2015) Mohamed Abu-Farha et al.   Scientific Reports

Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals

(2014) Anna Fenzl et al.   DIABETOLOGIA

Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression

(2014) Yoonjin Lee et al.   NATURE

PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s

(2014) Juan Carlos Corona et al.   NEUROCHEMICAL RESEARCH

Characterisation of betatrophin concentrations in childhood and adolescent obesity and insulin resistance

(2014) Shimin Wu et al.   PEDIATRIC DIABETES

GSK3β Is Increased in Adipose Tissue and Skeletal Muscle from Women with Gestational Diabetes Where It Regulates the Inflammatory Response

(2014) Martha Lappas   PLoS One

The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway

(2014) R Xu et al.   Cell Death & Disease

Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity

(2014) Zhiyao Fu et al.   Scientific Reports

Emerging roles of Lipasin as a critical lipid regulator

(2013) Ren Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes

(2013) Daniel Espes et al.   DIABETOLOGIA

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism

(2012) Gang Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Resistance to type 2 diabetes mellitus: a matter of hormesis?

(2011) Hubert Kolb et al.   Nature Reviews Endocrinology

Dynamic regulation of PGC-1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

(2009) Rozalyn M. Anderson et al.   AGING CELL

Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo

(2009) An-Chi Tsai et al.   CANCER LETTERS

Type 2 Diabetes in Youth: Epidemiology and Current Research toward Prevention and Treatment

(2008) Elizabeth J. Mayer-Davis   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION