- Home
- Publications
- Publication Search
- Publication Details
Title
Fibroblast Growth Factor 21—Metabolic Role in Mice and Men
Authors
Keywords
-
Journal
ENDOCRINE REVIEWS
Volume 38, Issue 5, Pages 468-488
Publisher
The Endocrine Society
Online
2017-07-29
DOI
10.1210/er.2017-00016
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- N-3 polyunsaturated fatty acids increase hepatic fibroblast growth factor 21 sensitivity via a PPAR-γ-β-klotho pathway
- (2017) Wenqi Yang et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Chronic Over-expression of Fibroblast Growth Factor 21 Increases Bile Acid Biosynthesis by Opposing FGF15/19 Action
- (2017) Jun Zhang et al. EBioMedicine
- Serum fibroblast growth factor 21 concentrations in type 2 diabetic retinopathy patients
- (2016) Alireza Esteghamati et al. ANNALES D ENDOCRINOLOGIE
- FGF21 Regulates Sweet and Alcohol Preference
- (2016) Saswata Talukdar et al. Cell Metabolism
- Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework
- (2016) Samantha M. Solon-Biet et al. Cell Metabolism
- A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects
- (2016) Saswata Talukdar et al. Cell Metabolism
- FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues
- (2016) Christian Schlein et al. Cell Metabolism
- FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver
- (2016) Stephanie von Holstein-Rathlou et al. Cell Metabolism
- Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance
- (2016) Xiao Yu Tian et al. Cell Metabolism
- Serum concentrations of fibroblast growth factor 21 are elevated in patients with congenital or acquired lipodystrophy
- (2016) Konstanze Miehle et al. CYTOKINE
- Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21
- (2016) Diana Ronai Dunshee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Exercise-Induced Secretion of FGF21 and Follistatin Are Blocked by Pancreatic Clamp and Impaired in Type 2 Diabetes
- (2016) Jakob Schiøler Hansen et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders
- (2016) Jenni M. Lehtonen et al. NEUROLOGY
- Elevated Serum Fibroblast Growth Factor 21 in Humans with Acute Pancreatitis
- (2016) Vivek K. Shenoy et al. PLoS One
- KLBis associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
- (2016) Gunter Schumann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution
- (2016) Yun-Hee Youm et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adiponectin, the past two decades
- (2016) Zhao V. Wang et al. Journal of Molecular Cell Biology
- Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health
- (2016) Luigi Fontana et al. Cell Reports
- Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle
- (2016) Bolormaa Vandanmagsar et al. Cell Reports
- Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas
- (2016) Garima Singhal et al. PLoS One
- Hypothalamic Inflammation in the Control of Metabolic Function
- (2015) Martin Valdearcos et al. Annual Review of Physiology
- Circulating FGF21 proteolytic processing mediated by fibroblast activation protein
- (2015) E. Y. Zhen et al. BIOCHEMICAL JOURNAL
- Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa
- (2015) Pouneh K. Fazeli et al. BONE
- Pharmacokinetics and pharmacodynamics of PF-05231023, a novel long-acting FGF21 mimetic, in a first-in-human study
- (2015) Jennifer Q. Dong et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Serum fibroblast growth factor 21 levels are related to subclinical atherosclerosis in patients with type 2 diabetes
- (2015) Yang Xiao et al. Cardiovascular Diabetology
- Serum fibroblast growth factor 21 levels is associated with lower extremity atherosclerotic disease in Chinese female diabetic patients
- (2015) Xiaoyan Zhang et al. Cardiovascular Diabetology
- A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption
- (2015) Xunde Wang et al. Cell Metabolism
- Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue
- (2015) Murielle M. Véniant et al. Cell Metabolism
- Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice
- (2015) Z. Lin et al. CIRCULATION
- Perilipin 5–Driven Lipid Droplet Accumulation in Skeletal Muscle Stimulates the Expression of Fibroblast Growth Factor 21
- (2015) Lydia-Ann L.S. Harris et al. DIABETES
- Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial
- (2015) Shihui Chen et al. DIGESTIVE AND LIVER DISEASE
- Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice
- (2015) Nicholas Douris et al. ENDOCRINOLOGY
- Short-term and Divergent Regulation of FGF-19 and FGF-21 during Oral Lipid Tolerance Test but not Oral Glucose Tolerance Test
- (2015) A. Schmid et al. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
- Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR–YY1–PGC1α pathway
- (2015) Kunqian Ji et al. FREE RADICAL BIOLOGY AND MEDICINE
- Visceral abdominal fat accumulation predicts the conversion of metabolically healthy obese subjects to an unhealthy phenotype
- (2015) Y-C Hwang et al. INTERNATIONAL JOURNAL OF OBESITY
- Circulating Fibroblast Growth Factor 21 Levels Predict Progressive Kidney Disease in Subjects With Type 2 Diabetes and Normoalbuminuria
- (2015) C. H. Lee et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- FGF21 and the late adaptive response to starvation in humans
- (2015) Pouneh K. Fazeli et al. JOURNAL OF CLINICAL INVESTIGATION
- Hepatic insulin resistance and increased hepatic glucose production in mice lackingFgf21
- (2015) João Paulo G Camporez et al. JOURNAL OF ENDOCRINOLOGY
- Association between Serum Fibroblast Growth Factor 21 and Coronary Artery Disease in Patients with Type 2 Diabetes
- (2015) Won Jin Kim et al. JOURNAL OF KOREAN MEDICAL SCIENCE
- Glucocorticoids Regulate the Metabolic Hormone FGF21 in a Feed-Forward Loop
- (2015) Rucha Patel et al. MOLECULAR ENDOCRINOLOGY
- Impaired insulin action in the human brain: causes and metabolic consequences
- (2015) Martin Heni et al. Nature Reviews Endocrinology
- Expression Atlas update—an integrated database of gene and protein expression in humans, animals and plants
- (2015) Robert Petryszak et al. NUCLEIC ACIDS RESEARCH
- Attenuated fibroblast growth factor 21 response to acute aerobic exercise in obese individuals
- (2015) A.L. Slusher et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction
- (2015) Wenduo Zhang et al. PLoS One
- Adipokines in health and disease
- (2015) Mathias Fasshauer et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice
- (2015) W Y So et al. Cell Death & Disease
- Serum FGF21 levels are associated with brown adipose tissue activity in humans
- (2015) Mark J.W. Hanssen et al. Scientific Reports
- FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance
- (2015) Barbara Bernardo et al. Scientific Reports
- FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1
- (2015) Michelle M. Kwon et al. Cell Reports
- Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1
- (2015) Ricardo J. Samms et al. Cell Reports
- The Fibroblast Growth Factor signaling pathway
- (2015) David M. Ornitz et al. Wiley Interdisciplinary Reviews-Developmental Biology
- Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes
- (2015) Lucia Berti et al. Molecular Metabolism
- Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion
- (2015) Susanne Keipert et al. Molecular Metabolism
- Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans
- (2015) Jakob Schiøler Hansen et al. Molecular Metabolism
- Ketogenic Diet Impairs FGF21 Signaling and Promotes Differential Inflammatory Responses in the Liver and White Adipose Tissue
- (2015) Mohamed Asrih et al. PLoS One
- Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21
- (2014) Emma K. Lees et al. AGING CELL
- Silencing of the Fibroblast growth factor 21 gene is an underlying cause of acinar cell injury in mice lacking MIST1
- (2014) Charis L. Johnson et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss
- (2014) Bryn M. Owen et al. Cell Metabolism
- Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans
- (2014) Paul Lee et al. Cell Metabolism
- Fibroblast growth factor-21, body composition, and insulin resistance in pre-pubertal and early pubertal males and females
- (2014) Lynae J. Hanks et al. CLINICAL ENDOCRINOLOGY
- FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting
- (2014) Q. Liang et al. DIABETES
- Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
- (2014) K. R. Markan et al. DIABETES
- Fibroblast Growth Factor 21 and Thyroid Hormone Show Mutual Regulatory Dependency but Have Independent Actions In Vivo
- (2014) Eleni M. Domouzoglou et al. ENDOCRINOLOGY
- FGF-21 and Skeletal Remodeling During and After Lactation in C57BL/6J Mice
- (2014) Sheila Bornstein et al. ENDOCRINOLOGY
- Possible role of fibroblast growth factor 21 on atherosclerosis via amelioration of endoplasmic reticulum stress-mediated apoptosis in apoE−/− mice
- (2014) Xi Wu et al. HEART AND VESSELS
- Serum Fibroblast Growth Factor 21 Levels Are Inversely Associated with Growth Rates in Infancy
- (2014) VerÓnica Mericq et al. Hormone Research in Paediatrics
- Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients
- (2014) J M Gallego-Escuredo et al. INTERNATIONAL JOURNAL OF OBESITY
- Adipose tissue gene expression and metabolic health of obese adults
- (2014) S K Das et al. INTERNATIONAL JOURNAL OF OBESITY
- Associations between serum hepcidin level, FGF-21 level and oxidative stress with arterial stiffness in CAPD patients
- (2014) Sena Memnune Ulu et al. INTERNATIONAL UROLOGY AND NEPHROLOGY
- Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced Hepatic Steatosis
- (2014) Shan Jiang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cardiorespiratory Fitness and Visceral Fat Are Key Determinants of Serum Fibroblast Growth Factor 21 Concentration in Japanese Men
- (2014) Hirokazu Taniguchi et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Interplay between FGF21 and insulin action in the liver regulates metabolism
- (2014) Brice Emanuelli et al. JOURNAL OF CLINICAL INVESTIGATION
- FGF21 is an endocrine signal of protein restriction
- (2014) Thomas Laeger et al. JOURNAL OF CLINICAL INVESTIGATION
- Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet
- (2014) Mingming Gao et al. JOURNAL OF CONTROLLED RELEASE
- Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans
- (2014) Ylva Bonde et al. JOURNAL OF LIPID RESEARCH
- Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis
- (2014) Manoja K. Brahma et al. JOURNAL OF LIPID RESEARCH
- Metabolic Signatures of Cultured Human Adipocytes from Metabolically Healthy versus Unhealthy Obese Individuals
- (2014) Anja Böhm et al. PLoS One
- Fibroblast growth factor-21 concentration in serum and synovial fluid is associated with radiographic bone loss of knee osteoarthritis
- (2014) Zhan-Chun Li et al. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
- Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease
- (2014) Giuseppe Paradies WORLD JOURNAL OF GASTROENTEROLOGY
- Role of Dietary Fats in Modulating Cardiometabolic Risk During Moderate Weight Gain: A Randomized Double‐Blind Overfeeding Trial (LIPOGAIN Study)
- (2014) David Iggman et al. Journal of the American Heart Association
- Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women
- (2014) Z. I. Akyildiz et al. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
- Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1
- (2014) Johanna Mäkelä et al. SpringerPlus
- Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
- (2013) Toshiko Tanaka et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine
- (2013) Susanne Keipert et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Serum Fibroblast Growth Factor-21 Levels Are Associated With Carotid Atherosclerosis Independent of Established Cardiovascular Risk Factors
- (2013) Wing Sun Chow et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- The cell adhesion molecule L1 regulates the expression of FGF21 and enhances neurite outgrowth
- (2013) Xiaohua Huang et al. BRAIN RESEARCH
- Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease
- (2013) Yun Shen et al. Cardiovascular Diabetology
- Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice
- (2013) Zhuofeng Lin et al. Cell Metabolism
- An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
- (2013) William L. Holland et al. Cell Metabolism
- The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes
- (2013) Gregory Gaich et al. Cell Metabolism
- Serum levels of fibroblast growth factor-21 are increased in chronic and acute renal dysfunction
- (2013) Janka Hindricks et al. CLINICAL ENDOCRINOLOGY
- Serum levels of the adipokine fibroblast growth factor-21 are increased in preeclampsia
- (2013) Holger Stepan et al. CYTOKINE
- Fibroblast Growth Factor 21 (FGF21) and Glucagon-Like Peptide 1 Contribute to Diabetes Resistance in Glucagon Receptor-Deficient Mice
- (2013) B. A. Omar et al. DIABETES
- High Glucose Represses -Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets: Involvement of Peroxisome Proliferator-Activated Receptor Signaling
- (2013) W. Y. So et al. DIABETES
- Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions
- (2013) K. M. Habegger et al. DIABETES
- Lipid sensing in the brain and regulation of energy balance
- (2013) V.-S. Moullé et al. DIABETES & METABOLISM
- Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice
- (2013) João Paulo G. Camporez et al. ENDOCRINOLOGY
- Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21
- (2013) Yu Li et al. GASTROENTEROLOGY
- Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron–sulfur cluster depletion in human skeletal muscle
- (2013) Daniel R. Crooks et al. HUMAN MOLECULAR GENETICS
- Novel locus including FGF21 is associated with dietary macronutrient intake
- (2013) Audrey Y. Chu et al. HUMAN MOLECULAR GENETICS
- Retinoic Acid Receptor β Stimulates Hepatic Induction of Fibroblast Growth Factor 21 to Promote Fatty Acid Oxidation and Control Whole-body Energy Homeostasis in Mice
- (2013) Yu Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Circulating Levels of FGF-21 in Obese Youth: Associations With Liver Fat Content and Markers of Liver Damage
- (2013) Cosimo Giannini et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Influence of growth hormone on circulating fibroblast growth factor 21 levels in humans
- (2013) J. Lundberg et al. JOURNAL OF INTERNAL MEDICINE
- FGF21 mediates the lipid metabolism response to amino acid starvation
- (2013) Ana Luísa De Sousa-Coelho et al. JOURNAL OF LIPID RESEARCH
- Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
- (2013) Steven E Kahn et al. LANCET
- Association of fibroblast growth factor (FGF-21) as a biomarker with primary mitochondrial disorders, but not with secondary mitochondrial disorders (Friedreich Ataxia)
- (2013) Mohammad Hossein Salehi et al. MOLECULAR BIOLOGY REPORTS
- FGF21 regulates metabolism and circadian behavior by acting on the nervous system
- (2013) Angie L Bookout et al. NATURE MEDICINE
- The role of hepatokines in metabolism
- (2013) Norbert Stefan et al. Nature Reviews Endocrinology
- Fibroblast growth factor 21 is a sensitive biomarker of mitochondrial disease
- (2013) R. L. Davis et al. NEUROLOGY
- Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319
- (2013) Alexei Kharitonenkov et al. PLoS One
- Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans
- (2013) Kook Hwan Kim et al. PLoS One
- Fgf21 Impairs Adipocyte Insulin Sensitivity in Mice Fed a Low-Carbohydrate, High-Fat Ketogenic Diet
- (2013) Yusuke Murata et al. PLoS One
- Serum Concentrations of Fibroblast Growth Factors 19 and 21 in Women with Gestational Diabetes Mellitus: Association with Insulin Resistance, Adiponectin, and Polycystic Ovary Syndrome History
- (2013) Dongyu Wang et al. PLoS One
- Metabolically Protective Cytokines Adiponectin and Fibroblast Growth Factor-21 Are Increased by Acute Overfeeding in Healthy Humans
- (2013) Leonie K. Heilbronn et al. PLoS One
- Genomic responses in mouse models poorly mimic human inflammatory diseases
- (2013) Junhee Seok et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial- and endoplasmic reticulum stress-dependent pathways in the mouse model
- (2013) Xin Jiang et al. TOXICOLOGY LETTERS
- Methionine and choline regulate the metabolic phenotype of a ketogenic diet
- (2013) Pavlos Pissios et al. Molecular Metabolism
- Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones
- (2013) Andrew C. Adams et al. Molecular Metabolism
- Adiponectin, driver or passenger on the road to insulin sensitivity?
- (2013) Risheng Ye et al. Molecular Metabolism
- Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
- (2012) Ana Luísa De Sousa-Coelho et al. BIOCHEMICAL JOURNAL
- Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones
- (2012) Paul A. Dutchak et al. CELL
- Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
- (2012) Jun Wu et al. CELL
- βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism
- (2012) Xunshan Ding et al. Cell Metabolism
- FGF21 in ataxia patients with spinocerebellar atrophy and mitochondrial disease
- (2012) Shih-Li Su et al. CLINICA CHIMICA ACTA
- Serum FGF21 concentration is associated with hypertriglyceridaemia, hyperinsulinaemia and pericardial fat accumulation, independently of obesity, but not with current coronary artery status
- (2012) Yenna Lee et al. CLINICAL ENDOCRINOLOGY
- Fibroblast Growth Factor 21 Predicts the Metabolic Syndrome and Type 2 Diabetes in Caucasians
- (2012) T. Bobbert et al. DIABETES CARE
- Serum fibroblast growth factor 21 was elevated in subjects with type 2 diabetes mellitus and was associated with the presence of carotid artery plaques
- (2012) So-Yeon An et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis?
- (2012) A. M. Arafat et al. DIABETOLOGIA
- Impact of short-term high-fat feeding and insulin-stimulated FGF21 levels in subjects with low birth weight and controls
- (2012) Sara G Vienberg et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- FGF21 regulates PGC-1 and browning of white adipose tissues in adaptive thermogenesis
- (2012) f. M. Fisher et al. GENES & DEVELOPMENT
- Activation of the Farnesoid X Receptor Induces Hepatic Expression and Secretion of Fibroblast Growth Factor 21
- (2012) Holly A. Cyphert et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Relationship of Serum Fibroblast Growth Factor 21 with Abnormal Glucose Metabolism and Insulin Resistance: The Baltimore Longitudinal Study of Aging
- (2012) Richard D. Semba et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Dynamic Change of Serum FGF21 Levels in Response to Glucose Challenge in Human
- (2012) Zhuofeng Lin et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Fibroblast Growth Factor 21 (FGF-21) and Its Relation to Obesity, Metabolic Syndrome, and Nonalcoholic Fatty Liver in Children: A Longitudinal Analysis
- (2012) Thomas Reinehr et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Long-Term Fenofibrate Therapy Increases Fibroblast Growth Factor 21 and Retinol-Binding Protein 4 in Subjects with Type 2 Diabetes
- (2012) Kwok Leung Ong et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Mild Cold Exposure Modulates Fibroblast Growth Factor 21 (FGF21) Diurnal Rhythm in Humans: Relationship between FGF21 Levels, Lipolysis, and Cold-Induced Thermogenesis
- (2012) Paul Lee et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Fibroblast growth factor-21 serum concentrations are associated with metabolic and hepatic markers in humans
- (2012) Susan Kralisch et al. JOURNAL OF ENDOCRINOLOGY
- Elevated serum fibroblast growth factor 21 is associated with hypertension in community-dwelling adults
- (2012) R D Semba et al. JOURNAL OF HUMAN HYPERTENSION
- Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB
- (2012) Chaofeng Yang et al. PLoS One
- Exercise Increases Serum Fibroblast Growth Factor 21 (FGF21) Levels
- (2012) Daniel Cuevas-Ramos et al. PLoS One
- FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice
- (2012) Murielle M. Véniant et al. PLoS One
- FGF21 Requires βklotho to Act In Vivo
- (2012) Andrew C. Adams et al. PLoS One
- Methionine-Restricted C57BL/6J Mice Are Resistant to Diet-Induced Obesity and Insulin Resistance but Have Low Bone Density
- (2012) Gene P. Ables et al. PLoS One
- Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor
- (2012) W. Wei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial dysfunction in pancreatic β cells
- (2012) Sachin Supale et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease
- (2011) Ingrid C. Gaemers et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Exercise-induced myokines and their role in chronic diseases
- (2011) Bente K. Pedersen BRAIN BEHAVIOR AND IMMUNITY
- Circadian Rhythm of Circulating Fibroblast Growth Factor 21 Is Related to Diurnal Changes in Fatty Acids in Humans
- (2011) H. Yu et al. CLINICAL CHEMISTRY
- Effects of a three-month combined exercise programme on fibroblast growth factor 21 and fetuin-A levels and arterial stiffness in obese women
- (2011) Sae Jeong Yang et al. CLINICAL ENDOCRINOLOGY
- Plasma FGF21 displays a circadian rhythm during a 72-h fast in healthy female volunteers
- (2011) Birgitte Andersen et al. CLINICAL ENDOCRINOLOGY
- Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid
- (2011) Bee K. Tan et al. DIABETES
- FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents
- (2011) J. Mu et al. DIABETES
- High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects
- (2011) C. Chen et al. DIABETES CARE
- Serum FGF21 levels are increased in newly diagnosed type 2 diabetes with nonalcoholic fatty liver disease and associated with hsCRP levels independently
- (2011) Xuesong Li et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Alterations of Hormonally Active Fibroblast Growth Factors after Roux-en-Y Gastric Bypass Surgery
- (2011) Peter L.M. Jansen et al. DIGESTIVE DISEASES
- Serum FGF-21 Levels in Type 2 Diabetic Patients
- (2011) Xingbo Cheng et al. ENDOCRINE RESEARCH
- Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21)in Vivo
- (2011) ffolliott M. Fisher et al. ENDOCRINOLOGY
- Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance
- (2011) Clarence Hale et al. ENDOCRINOLOGY
- Decrease in circulating fibroblast growth factor 21 after an oral fat load is related to postprandial triglyceride-rich lipoproteins and liver fat
- (2011) Niina Matikainen et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis
- (2011) Srinivasan Dasarathy et al. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
- Growth Hormone Induces Hepatic Production of Fibroblast Growth Factor 21 through a Mechanism Dependent on Lipolysis in Adipocytes
- (2011) Wei Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes
- (2011) Xuan Ge et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue
- (2011) Elayne Hondares et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study
- (2011) Anu Suomalainen et al. LANCET NEUROLOGY
- Association between serum fibroblast growth factor 21 and diabetic nephropathy
- (2011) Wei-Xia Jian et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes
- (2011) Y. Zhang et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- The effects of fibroblast growth factor-21 knockdown and over-expression on its signaling pathway and glucose–lipid metabolism in vitro
- (2011) Ke Li et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Circulating FGF21 Levels Are Progressively Increased from the Early to End Stages of Chronic Kidney Diseases and Are Associated with Renal Function in Chinese
- (2011) Zhuofeng Lin et al. PLoS One
- Circulating Fibroblast Growth Factor 21 Levels Are Closely Associated with Hepatic Fat Content: A Cross-Sectional Study
- (2011) Hongmei Yan et al. PLoS One
- Effects of postbariatric surgery weight loss on adipokines and metabolic parameters: comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy—a prospective randomized trial
- (2011) Bettina Woelnerhanssen et al. Surgery for Obesity and Related Diseases
- Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients
- (2010) Pere Domingo et al. AIDS
- Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat
- (2010) Elayne Hondares et al. Cell Metabolism
- Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
- (2010) f. M. Fisher et al. DIABETES
- Distinct association of serum FGF21 or adiponectin levels with clinical parameters in patients with type 2 diabetes
- (2010) Kazuhiro Eto et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease
- (2010) Yusuf Yilmaz et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Daily physical activity, fasting glucose, uric acid, and body mass index are independent factors associated with serum fibroblast growth factor 21 levels
- (2010) Daniel Cuevas-Ramos et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- FGF21 signalling pathway and metabolic traits – genetic association analysis
- (2010) Bernhard M Kaess et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease
- (2010) Jody Dushay et al. GASTROENTEROLOGY
- Mitochondrial myopathy induces a starvation-like response
- (2010) Henna Tyynismaa et al. HUMAN MOLECULAR GENETICS
- Thyroid Hormone Regulates Hepatic Expression of Fibroblast Growth Factor 21 in aPPARα-dependent Manner
- (2010) Andrew C. Adams et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of FGF21 Expression and Secretion by Retinoic Acid Receptor-related Orphan Receptor α
- (2010) Yongjun Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transcriptional Repressor E4-binding Protein 4 (E4BP4) Regulates Metabolic Hormone Fibroblast Growth Factor 21 (FGF21) during Circadian Cycles and Feeding
- (2010) Xin Tong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Liver Fat But Not Other Adiposity Measures Influence Circulating FGF21 Levels in Healthy Young Adult Twins
- (2010) Henna Tyynismaa et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
- (2010) Huating Li et al. JOURNAL OF HEPATOLOGY
- Serum fibroblast growth factor–21 concentration is associated with residual renal function and insulin resistance in end-stage renal disease patients receiving long-term peritoneal dialysis
- (2010) Seung Hyeok Han et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse
- (2010) Klementina Fon Tacer et al. MOLECULAR ENDOCRINOLOGY
- Serum Levels of FGF-21 Are Increased in Coronary Heart Disease Patients and Are Independently Associated with Adverse Lipid Profile
- (2010) Zhuofeng Lin et al. PLoS One
- Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects
- (2009) Jing Xu et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Free Fatty Acids Link Metabolism and Regulation of the Insulin-Sensitizing Fibroblast Growth Factor-21
- (2009) K. Mai et al. DIABETES
- Fibroblast Growth Factor-21 Is Induced in Human Skeletal Muscles by Hyperinsulinemia
- (2009) Pernille Hojman et al. DIABETES
- Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance
- (2009) A. O. Chavez et al. DIABETES CARE
- Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity
- (2009) Eric D. Berglund et al. ENDOCRINOLOGY
- Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis
- (2009) Michael K. Badman et al. ENDOCRINOLOGY
- Fibroblast Growth Factor 21 Regulates Lipolysis in White Adipose Tissue But Is Not Required for Ketogenesis and Triglyceride Clearance in Liver
- (2009) Yuhei Hotta et al. ENDOCRINOLOGY
- Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 inob/obmice
- (2009) Xiaofan Li et al. FEBS LETTERS
- Fibroblast Growth Factor 21 Reduces the Severity of Cerulein-Induced Pancreatitis in Mice
- (2009) Charis L. Johnson et al. GASTROENTEROLOGY
- Different roles of N- and C- termini in the functional activity of FGF21
- (2009) Radmila Micanovic et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Serum Fibroblast Growth Factor 21 Is Associated with Adverse Lipid Profiles and γ-Glutamyltransferase But Not Insulin Sensitivity in Chinese Subjects
- (2009) Huating Li et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Circulating Fibroblast Growth Factor 21 Is Induced by Peroxisome Proliferator-Activated Receptor Agonists But Not Ketosis in Man
- (2009) Constantinos Christodoulides et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Serum fibroblast growth factor 21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia
- (2009) Sebastian Stein et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis
- (2009) Jennifer L. Estall et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FGF21 induces PGC-1 and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
- (2009) M. J. Potthoff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification and Characterization of Metabolically Benign Obesity in Humans
- (2008) Norbert Stefan ARCHIVES OF INTERNAL MEDICINE
- Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21
- (2008) Takeshi Inagaki et al. Cell Metabolism
- The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man
- (2008) Cecilia Gälman et al. Cell Metabolism
- Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity
- (2008) M. Mraz et al. CLINICAL ENDOCRINOLOGY
- Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans
- (2008) X. Zhang et al. DIABETES
- Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
- (2008) J. Xu et al. DIABETES
- Serum Levels of the Adipokine FGF21 Depend on Renal Function
- (2008) S. Stein et al. DIABETES CARE
- Plasma FGF-21 levels in type 2 diabetic patients with ketosis
- (2008) Ling Li et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Causes and Metabolic Consequences of Fatty Liver
- (2008) Norbert Stefan et al. ENDOCRINE REVIEWS
- Fibroblast Growth Factor 21 Corrects Obesity in Mice
- (2008) Tamer Coskun et al. ENDOCRINOLOGY
- FGF21 attenuates lipolysis in human adipocytes - A possible link to improved insulin sensitivity
- (2008) Peter Arner et al. FEBS LETTERS
- FGF21 N- and C-termini play different roles in receptor interaction and activation
- (2008) Junming Yie et al. FEBS LETTERS
- FGF21 is an Akt-regulated myokine
- (2008) Yasuhiro Izumiya et al. FEBS LETTERS
- βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c
- (2008) Masashi Suzuki et al. MOLECULAR ENDOCRINOLOGY
- Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor and Altered Metabolic States
- (2008) E. S. Muise et al. MOLECULAR PHARMACOLOGY
- FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho
- (2007) Alexei Kharitonenkov et al. JOURNAL OF CELLULAR PHYSIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started