Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage

Evaluation of the Escherichia coli HK82 and BS87 strains as tools for AlkB studies

(2016) D. Mielecki et al.   DNA REPAIR

Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase

(2015) Y. Zhao et al.   EMBO JOURNAL

Rhein: A Review of Pharmacological Activities

(2015) Yan-Xi Zhou et al.   Evidence-based Complementary and Alternative Medicine

Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein

(2015) Tianlu Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents

(2015) Pu Wang et al.   Cell Reports

The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells

(2015) Robert Liefke et al.   Genome Medicine

Switching Demethylation Activities between AlkB Family RNA/DNA Demethylases through Exchange of Active-Site Residues

(2014) Chenxu Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs

(2014) Syuhei Nakao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

(2014) Yue Huang et al.   NUCLEIC ACIDS RESEARCH

Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches

(2014) Felix Dietlein et al.   TRENDS IN GENETICS

Removal of N-Alkyl Modifications from N2-Alkylguanine and N4-Alkylcytosine in DNA by the Adaptive Response Protein AlkB

(2013) Deyu Li et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)

(2013) WeiShen Aik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Target validation using chemical probes

(2013) Mark E Bunnage et al.   Nature Chemical Biology

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

The complex structures of ALKBH2 mutants cross-linked to dsDNA reveal the conformational swing of β-hairpin

(2013) BaoEn Chen et al.   Science China-Chemistry

5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation

(2013) Richard J. Hopkinson et al.   Chemical Science

ABH2 Couples Regulation of Ribosomal DNA Transcription with DNA Alkylation Repair

(2013) Pishun Li et al.   Cell Reports

Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response

(2012) Cathrine Broberg Vågbø et al.   DNA REPAIR

Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs

(2012) Ajay Srinivasan et al.   Future Medicinal Chemistry

Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

(2012) Esther C. Y. Woon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor

(2012) Baoen Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Duplex interrogation by a direct DNA repair protein in search of base damage

(2012) Chengqi Yi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells

(2012) Tor-Christian Aase Johannessen et al.   NEURO-ONCOLOGY

Inhibition of 2-oxoglutarate dependent oxygenases

(2011) Nathan R. Rose et al.   CHEMICAL SOCIETY REVIEWS

DNA Unwinding by ASCC3 Helicase Is Coupled to ALKBH3-Dependent DNA Alkylation Repair and Cancer Cell Proliferation

(2011) Sebastian Dango et al.   MOLECULAR CELL

Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3

(2010) Baoen Chen et al.   Molecular BioSystems

Pediatric brain tumors: mutations of two dioxygenases (hABH2 and hABH3) that directly repair alkylation damage

(2009) Valentina Cetica et al.   JOURNAL OF NEURO-ONCOLOGY

Lethal and mutagenic properties of MMS-generated DNA lesions in Escherichia coli cells deficient in BER and AlkB-directed DNA repair

(2009) A. Sikora et al.   MUTAGENESIS

Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria

(2009) Erwin van den Born et al.   NUCLEIC ACIDS RESEARCH

Dynamic states of the DNA repair enzyme AlkB regulate product release

(2008) Boris Bleijlevens et al.   EMBO REPORTS

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA

(2008) Cai-Guang Yang et al.   NATURE