Review
Medicine, Research & Experimental
Wanying Feng, Zhihua Yang, Yangxi Liu, Rui Chen, Zhihui Song, Guiyun Pan, Yuhang Zhang, Zehui Guo, Xinya Ding, Lu Chen, Yi Wang
Summary: All species have a physiological need for sleep, which plays a crucial role in preserving and restoring physiological processes. Recent research points to the influence of gut microbiota on brain function, revealing their relationship. Dysregulation of the gut-brain axis is found to be linked to insomnia, with certain gut microbiota metabolites and disturbances worsening the condition. Traditional Chinese medicine offers unique advantages in treating insomnia, and exploring its scientific relevance to gut microbiota may lead to new concepts and improved therapeutics.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Integrative & Complementary Medicine
Hui Zhao, Man He, Meng Zhang, Qiang Sun, Sha Zeng, Li Chen, Han Yang, Maolun Liu, Shan Ren, Xianli Meng, Haibo Xu
Summary: The text discusses the pathogenesis of colorectal cancer, the types and functions of gut microbiota, and the research on traditional Chinese medicine in treating colorectal cancer by regulating the gut microbiota. It emphasizes the importance of regulating the gut microbiota for disease treatment.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Plant Sciences
Boru Li, Meijing Xu, Yu Wang, Lijin Feng, Hang Xing, Kuo Zhang
Summary: This article summarizes the pharmacological effects, targets, and mechanisms of traditional Chinese medicine (TCM) in improving depression by regulating the gut microbiota. It provides evidence that TCMs are safe and effective in the treatment of depression and may offer a new therapeutic approach.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Qianqian Wang, Min Guo, Yang Liu, Mengshu Xu, Liuting Shi, Xiu Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: This study found that certain strains of Bifidobacterium can reduce the production of plasma TMAO and modulate the gut microbiota. These strains may have therapeutic potential for preventing TMAO-related diseases such as atherosclerosis.
Review
Immunology
Chenxi Zhang, Peng Xue, Haiyan Zhang, Chenxi Tan, Shiyao Zhao, Xudong Li, Lihui Sun, Huihui Zheng, Jun Wang, Baoling Zhang, Weiya Lang
Summary: This review provides an overview of the role of the gut microbiota in adult neurogenesis and proposes the potential effects of traditional Chinese medicine on neurogenesis through regulation of the gut microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Md. Mominur Rahman, Fahadul Islam, Md. Harun-Or-Rashid, Abdullah Al Mamun, Md. Saidur Rahaman, Md. Mohaimenul Islam, Atkia Farzana Khan Meem, Popy Rani Sutradhar, Saikat Mitra, Anjuman Ara Mimi, Talha Bin Emran, Fatimawali, Rinaldi Idroes, Trina Ekawati Tallei, Muniruddin Ahmed, Simona Cavalu
Summary: In recent years, there has been considerable interest in studying the development and effects of the gut microbiota on the human body, especially its relationship to cardiovascular diseases. The gut microbiota plays a crucial role in human health and can influence the development of cardiovascular diseases such as heart failure and atherosclerosis. Research on the gut microbiota and stroke pathogenesis can provide new therapeutic prospects.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Integrative & Complementary Medicine
Tian-Yi Cheng, Jia-Xin Li, Jing-Yi Chen, Pei-Ying Chen, Lin-Rui Ma, Gui-Lin Zhang, Pei-Yu Yan
Summary: Coronary heart disease (CHD) is a common ischaemic heart disease with a yet fully elucidated pathological mechanism. Changes in gut microbiota (GM) composition and metabolites are associated with the risk of CHD, while traditional Chinese medicine interventions can regulate GM to intervene in CHD.
Review
Endocrinology & Metabolism
Donghui Li, Weiwei Tang, Yanyan Wang, Qi Gao, Hongwei Zhang, Yu Zhang, Yuliang Wang, Yongyi Yang, Yingming Zhou, Yike Zhang, Haonan Li, Shuo Li, Hong Zhao
Summary: Obesity is a chronic metabolic disease caused by multiple factors. High-fat diets disrupt the gut microbiota and impair gut barrier function in obese individuals. This leads to an imbalance in energy metabolism and inflammatory response, contributing to the development of chronic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, Research & Experimental
Wuwen Feng, Juan Liu, Lihua Huang, Yuzhu Tan, Cheng Peng
Summary: Traditional Chinese medicines (TCMs) are gaining global recognition for their efficacy, but concerns about their toxicity, influenced by gut microbiota, are also rising. Research on the interaction between gut microbiota and TCMs' toxicity is essential to better understand and minimize the risks associated with TCM use.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Hai-Yu Zhang, Jia-Xing Tian, Feng-Mei Lian, Min Li, Wen-Ke Liu, Zhong Zhen, Jiang-Quan Liao, Xiao-Lin Tong
Summary: Traditional Chinese medicines have shown considerable effects in treating metabolic disorders by regulating gut microbiota, particularly by affecting glucose and lipid metabolism through modulating specific types of bacteria. The potential mechanisms include protection of the intestinal barrier function, modulation of metabolic endotoxemia and inflammatory responses, regulation of SCFAs, modulation of the gut-brain axis, and regulation of bile acid and tryptophan metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Zhihua Yang, Yangxi Liu, Lin Wang, Shanshan Lin, Xiangdong Dai, Haifeng Yan, Zhao Ge, Qiuan Ren, Hui Wang, Feng Zhu, Shuping Wang
Summary: COVID-19 can cause gastrointestinal symptoms due to disruption of the gut microbiota. Traditional Chinese medicine has advantages in regulating the gut microbiota and has shown significant efficacy in the prevention and treatment of COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Plant Sciences
Yingying Li, Xinyu Ji, Haonan Wu, Xiang Li, Huamin Zhang, Danli Tang
Summary: This study reviewed the regulation of lipid metabolism by microbial metabolites in Traditional Chinese Medicine (TCM). It was found that TCM can effectively improve lipid metabolism through various mechanisms such as increasing SCFA levels, regulating BA metabolism, and reducing TMAO production. The findings suggest a potential new approach for better management of dyslipidemia in future clinical treatments.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Kaiyang Lin, Xuedong Wang, Ji Li, Peng Zhao, Xiangwen Xi, Yi Feng, Li Yin, Jinwei Tian, Hulun Li, Xinxin Liu, Bo Yu
Summary: The study suggests that geraniin may have pharmacological activity in atherosclerosis by remodeling the gut microbiota, reducing plasma TMAO levels, alleviating vascular inflammation, and reducing atherosclerotic characteristics.
Article
Integrative & Complementary Medicine
Qiao Zhang, Shijun Yue, Wenxiao Wang, Yanyan Chen, Chongbo Zhao, Yijun Song, Dan Yan, Li Zhang, Yuping Tang
Summary: The review discusses the relationship between COVID-19 and gut microbiota, suggesting that a combination of traditional Chinese medicine and western medication may be an effective treatment strategy. Data indicates that gut microbiota dysbiosis occurs in COVID-19 patients and that intervention in gut microbiota can improve the clinical condition of patients. Certain Chinese herbs have shown to have a regulatory effect on gut microbiota, immunity, and ACE2, with the possibility of gut microbiota mediating the efficacy of TCM treatment for COVID-19.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Review
Immunology
Yujiao Liang, Mengyao Liu, Yingxue Cheng, Xinchang Wang, Weijie Wang
Summary: This article mainly explores the relationship between Traditional Chinese Medicine (TCM) and gut microbiota in treating Rheumatoid arthritis (RA). It comprehensively summarizes the roles of gut microbiota in the onset and development of RA, and elucidates the mechanism of TCM in preventing and treating RA by influencing the microbiota.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lanying Liu, Zhilu Zou, Jiangwei Yang, Xiaoqi Li, Boran Zhu, Hailou Zhang, Yan Sun, Yuxuan Zhang, Zhang-Jin Zhang, Wei Wang
Summary: This study found that Jianpi Jieyu decoction can regulate gut microbiota to produce antidepressant effects and improve cognitive deficits. The results showed that after administration of Jianpi Jieyu decoction, the serum levels of GABA and the expressions of GluR1 and p-Tau in the hippocampus of mice subjected to chronic unpredictable mild stress were reversed.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hailou Zhang, Yan Sun, Suk-yu Yau, Yanmeng Zhou, Xinxin Song, Han-Ting Zhang, Boran Zhu, Haoxin Wu, Gang Chen
Summary: This study identified that co-treatment with geniposide and shanzhiside methyl ester can rapidly trigger hippocampal PACAP activity and associated CaMKII-BDNF signaling, resulting in a synergistic rapid onset antidepressant action.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Plant Sciences
Ruiyi Liu, Yan Sun, Dong Di, Xiyuan Zhang, Boran Zhu, Haoxin Wu
Summary: This study used network pharmacology and in vivo experiments to demonstrate the potential therapeutic effects of Alisma orientalis beverage (AOB) in treating atherosclerosis (AS). The findings suggest that AOB improves blood lipids and inhibits the PI3K/AKT/SREBP-1 pathway in the liver, providing new evidence for the clinical application of AOB in the treatment of AS.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jingchun Du, Wei Wu, Boran Zhu, Weiwei Tao, Lina Liu, Xiaolan Cheng, Min Zhao, Jibiao Wu, Yunlun Li, Ke Pei
Summary: This paper comprehensively analyzes the factors influencing lipid metabolism, including obesity, genes, intestinal microflora, and ferroptosis, and delves deeply into the pathways and patterns of coronary heart disease. Based on these findings, various intervention pathways and therapeutic methods are proposed, such as regulating lipoprotein enzymes, lipid metabolites, and lipoprotein regulatory factors, as well as modulating intestinal microflora and inhibiting ferroptosis. Ultimately, this paper aims to offer new ideas for the prevention and treatment of coronary heart disease.
CHEMISTRY AND PHYSICS OF LIPIDS
(2023)
Article
Plant Sciences
Jing Liu, Shihan Zhou, Yanqing Wang, Jinling Liu, SuPing Sun, Yan Sun, Ping Xu, Xu Xu, Boran Zhu, Haoxin Wu
Summary: This study mainly investigated the therapeutic effects of ZeXieYin Formula (ZXYF) on TMAO-induced cognitive impairment in mice and explored its underlying mechanism. The results showed that ZXYF could improve the declined learning and memory ability caused by TMAO, partially restore the damage of hippocampal synapse and neurons, and exert its effects by regulating the expression of synapse-associated proteins and the mTOR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shihan Zhou, Jing Liu, Yan Sun, Ping Xu, Jin ling Liu, Suping Sun, Boran Zhu, Haoxin Wu
Summary: Mild cognitive impairment (MCI) is an intermediate state between healthy and dementia, which affects memory and cognitive function. Timely intervention and treatment of MCI can effectively prevent it from developing into an incurable neurodegenerative disease. Lifestyle factors, such as dietary habits, were highlighted as risk factors for MCI. The effect of a high-choline diet on cognitive function is contentious. This study focuses on the choline metabolite trimethylamine-oxide (TMAO) and its potential effect on synaptic plasticity in the hippocampus.