Shared Genetic Liability and Causal Associations Between Major Depressive Disorder and Cardiovascular Diseases

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

(2020) Sonia Shah et al.   Nature Communications

Major depressive disorder and cardiometabolic diseases: a bidirectional Mendelian randomisation study

(2020) Bowen Tang et al.   DIABETOLOGIA

Identification of Key Genes and the Pathophysiology Associated With Major Depressive Disorder Patients Based on Integrated Bioinformatics Analysis

(2020) Guangyin Zhang et al.   Frontiers in Psychiatry

Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence

(2019) Olav B Smeland et al.   MOLECULAR PSYCHIATRY

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

(2019) David M. Howard et al.   NATURE NEUROSCIENCE

Probabilistic fine-mapping of transcriptome-wide association studies

(2019) Nicholas Mancuso et al.   NATURE GENETICS

Implementing MR‐PRESSO and GCTA‐GSMR for pleiotropy assessment in Mendelian randomization studies from a practitioner's perspective

(2019) Jue‐Sheng Ong et al.   GENETIC EPIDEMIOLOGY

Genome-wide association study of peripheral artery disease in the Million Veteran Program

(2019) Derek Klarin et al.   NATURE MEDICINE

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

(2019) Oleksandr Frei et al.   Nature Communications

Association between major depressive disorder and multiple disease outcomes: a phenome-wide Mendelian randomisation study in the UK Biobank

(2019) Anwar Mulugeta et al.   MOLECULAR PSYCHIATRY

The effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: A PET imaging study

(2019) Enrico D'Ambrosio et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

(2019)   SCIENCE

Major depression and small vessel stroke: a Mendelian randomization analysis

(2019) Huan Cai et al.   JOURNAL OF NEUROLOGY

Integrating genome-wide association study and expression quantitative trait loci data identifies NEGR1 as a causal risk gene of major depression disorder

(2019) Xin Wang et al.   JOURNAL OF AFFECTIVE DISORDERS

Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease

(2019) Jessica Dennis et al.   MOLECULAR PSYCHIATRY

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

(2018) Yun J. Sung et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study

(2018) Cyril Pottier et al.   LANCET NEUROLOGY

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

(2018) Jeanne E. Savage et al.   NATURE GENETICS

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

(2018) Rainer Malik et al.   NATURE GENETICS

Multi-ethnic genome-wide association study for atrial fibrillation

(2018) Carolina Roselli et al.   NATURE GENETICS

Post stroke depression: The sequelae of cerebral stroke

(2018) Jyotirekha Das et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Causal associations between risk factors and common diseases inferred from GWAS summary data

(2018) Zhihong Zhu et al.   Nature Communications

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Association Between Population Density and Genetic Risk for Schizophrenia

(2018) Lucía Colodro-Conde et al.   JAMA Psychiatry

Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients With Acute Coronary Syndrome

(2018) Jae-Min Kim et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

(2018) Evangelos Evangelou et al.   NATURE GENETICS

GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

(2018) Joëlle A. Pasman et al.   NATURE NEUROSCIENCE

Effects of placental growth factor deficiency on behavior, neuroanatomy and cerebrovasculature of mice

(2018) Vanessa R. Kay et al.   PHYSIOLOGICAL GENOMICS

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Hmwe Hmwe Kyu et al.   LANCET

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

(2018) Ayush Giri et al.   NATURE GENETICS

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

(2018) Fumihiko Takeuchi et al.   Nature Communications

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Theo Vos et al.   LANCET

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

(2017) Zhiqiang Li et al.   NATURE GENETICS

Association analyses based on false discovery rate implicate new loci for coronary artery disease

(2017) Christopher P Nelson et al.   NATURE GENETICS

Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls

(2017) Christoph U. Correll et al.   World Psychiatry

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Phospholipase Cγ1 Mediates Intima Formation Through Akt‐Notch1 Signaling Independent of the Phospholipase Activity

(2017) Dongyang Jiang et al.   Journal of the American Heart Association

Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia

(2017) Joey Ward et al.   Translational Psychiatry

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease

(2017) Pim van der Harst et al.   CIRCULATION RESEARCH

Across-cohort QC analyses of GWAS summary statistics from complex traits

(2016) Guo-Bo Chen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The Elsevier trophoblast research award lecture: Impacts of placental growth factor and preeclampsia on brain development, behaviour, and cognition

(2016) Matthew T. Rätsep et al.   PLACENTA

Poststroke Depression: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association

(2016) Amytis Towfighi et al.   STROKE

Zinc fingers and homeoboxes family in human diseases

(2015) Y Liu et al.   CANCER GENE THERAPY

Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors

(2015) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease

(2015) Jessica Lauriol et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Efficient Test and Visualization of Multi-Set Intersections

(2015) Minghui Wang et al.   Scientific Reports

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions

(2014) Michael D. Gallagher et al.   ACTA NEUROPATHOLOGICA

Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension

(2014) Xiangfeng Lu et al.   HUMAN MOLECULAR GENETICS

A PLC 1-Dependent, Force-Sensitive Signaling Network in the Myogenic Constriction of Cerebral Arteries

(2014) A. L. Gonzales et al.   Science Signaling

Depression and cardiovascular disease: a clinical review

(2013) D. L. Hare et al.   EUROPEAN HEART JOURNAL

Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010

(2013) Harvey A Whiteford et al.   LANCET

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

(2013) Stephan Ripke et al.   NATURE GENETICS

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010

(2013) Alize J. Ferrari et al.   PLOS MEDICINE

A Subset-Based Approach Improves Power and Interpretation for the Combined Analysis of Genetic Association Studies of Heterogeneous Traits

(2012) Samsiddhi Bhattacharjee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Placental Growth Factor as a Protective Paracrine Effector in the Heart

(2012) Federica Accornero et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Placental Growth Factor Regulates Cardiac Adaptation and Hypertrophy Through a Paracrine Mechanism

(2011) Federica Accornero et al.   CIRCULATION RESEARCH

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

(2010) Vivianna M Van Deerlin et al.   NATURE GENETICS

Major Depression and Coronary Artery Disease in the Swedish Twin Registry

(2009) Kenneth S. Kendler et al.   ARCHIVES OF GENERAL PSYCHIATRY

Medical Comorbidity Affects Antidepressant Treatment Response in Patients with Melancholic Depression

(2009) K. Pohle et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Depression and Coronary Heart Disease

(2008) Judith H. Lichtman et al.   CIRCULATION

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE