Article
Clinical Neurology
Jason D. Hinman, Fanny Elahi, Davis Chong, Hannah Radabaugh, Adam Ferguson, Pauline Maillard, Jeffrey F. Thompson, Gary A. Rosenberg, Abhay Sagare, Abhay Moghekar, Hanzhang Lu, Tiffany Lee, Donna Wilcock, Claudia L. Satizabal, Russell Tracy, Sudha Seshadri, Kristin Schwab, Karl Helmer, Herpreet Singh, Pia Kivisakk, Steve Greenberg, Charlie DeCarli, Joel Kramer
Summary: This study found that plasma PlGF levels are associated with cognitive impairment and white matter injury, and can serve as a stable and reliable diagnostic biomarker.
ALZHEIMERS & DEMENTIA
(2023)
Article
Oncology
Tamara Kazimova, Fabienne Tschanz, Ashish Sharma, Irma Telarovic, Marco Wachtel, Gloria Pedot, Beat Schaefer, Martin Pruschy
Summary: Placental growth factor (PlGF) is regulated by p53 in response to ionizing radiation and plays a protective role in tumor angiogenesis. Studies suggest that targeting PlGF may be a promising approach for combined treatment with radiotherapy to improve therapeutic outcomes.
MOLECULAR CANCER RESEARCH
(2021)
Article
Rheumatology
Keishi Etori, Shigeru Tanaka, Jun Tamura, Koto Hattori, Shin-Ichiro Kagami, Junichi Nakamura, Seiji Ohtori, Hiroshi Nakajima
Summary: This study found that FGFR1 marks terminal effector Tph cells in patients with RA, suggesting its important role in the pathogenesis of RA.
Article
Engineering, Biomedical
Sevgi Onal, Merve Turker-Burhan, Gizem Bati-Ayaz, Hamdullah Yanik, Devrim Pesen-Okvur
Summary: The study found that macrophages exhibited chemotaxis towards BCC while BCC required direct contact to interact with macrophage-derived EGF. The interaction between breast cancer cells and macrophages is proposed to be a paracrine-juxtacrine loop involving CSF-1 and EGF, respectively.
Article
Obstetrics & Gynecology
Hiroaki Tanaka, Kayo Tanaka, Sho Takakura, Naosuke Enomoto, Shintaro Maki, Tomoaki Ikeda
Summary: This study tested the correlation between maternal placental growth factor (PlGF) and fetal heart rate (FHR) monitoring findings. The results showed that PlGF levels were associated with the mode of delivery and might be a promising biomarker of intrapartum fetal function.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Multidisciplinary Sciences
Dandan Wang, Lingfang Zhu, Xiangkai Zhen, Daoyan Yang, Changfu Li, Yating Chen, Huannan Wang, Yichen Qu, Xiaozhen Liu, Yanling Yin, Huawei Gu, Lei Xu, Chuanxing Wan, Yao Wang, Songying Ouyang, Xihui Shen
Summary: Bacteria have developed a secretion system to deliver effector proteins into neighboring cells, but the functions of many effectors are still unknown. In this study, the researchers identified an effector called CccR secreted by Yersinia pseudotuberculosis that can act as both a toxin and a transcription factor. CccR can enter nearby cells of the same and other species, and modulate gene expression and inhibit the growth of competitors.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Xiaoru Hu, Zhengwei Ma, Siyao Li, Lu Wen, Yuqing Huo, Guangyu Wu, Santhakumar Manicassamy, Zheng Dong
Summary: Kidney repair after injury involves the interaction between injured kidney tubules, interstitial fibroblasts, and immune cells. In this study, the induction of fibroblast growth factor 2 (FGF2) was detected in mouse kidneys and renal tubule cells treated with repeated low-dose cisplatin (RLDC). RLDC treatment led to increased FGF2 expression and secretion, promoting fibroblast proliferation and the expression of fibrosis-related proteins. FGF2 deficiency partially prevented RLDC-induced kidney dysfunction, fibrosis, and inflammation in mice. These findings highlight the important role of FGF2 as a paracrine factor in maladaptive kidney repair and disease progression.
LABORATORY INVESTIGATION
(2023)
Article
Obstetrics & Gynecology
Laura A. Magee, Argyro Syngelaki, Ranjit Akolekar, Peter von Dadelszen, Kypros H. Nicolaides
Summary: This study aimed to investigate the role of serum placental growth factor (PlGF) at 19-23 weeks of gestation in risk identification. The results showed that clinical risk factor screening had limitations in detecting adverse outcomes, and PlGF testing alone did not reduce false positives. Therefore, alternative strategies are needed to improve risk identification.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Paula Gastiazoro, Maria Florencia Rossetti, Rocio Schumacher, Cora Stoker, Milena Durando, Oliver Zierau, Jorge Guillermo Ramos, Jorgelina Varayoud
Summary: Maternal diet has a significant impact on reproduction, fetal development, and offspring behavior. This study demonstrates that chronic consumption of a Western-style diet impairs feto-placental development in female rats and may be attributed to epigenetic disruption of the Insulin-Like Growth Factor and Vascular Endothelial Growth Factor systems.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Public, Environmental & Occupational Health
Haosu Tang, Congyi Zheng, Xue Cao, Su Wang, Linfeng Zhang, Xin Wang, Zuo Chen, Yuxin Song, Chen Chen, Yixin Tian, Wenping Jiang, Gang Huang, Zengwu Wang
Summary: This study finds that blue sky may serve as an independent environmental protective factor against cardiovascular diseases (CVD).
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Pengxia Yu, Jin Zhou, Caiyun Ge, Man Fang, Yuanzhen Zhang, Hui Wang
Summary: This study demonstrates that high maternal glucocorticoids can regulate the expression of placental 11β-HSD2 in a sex-specific manner, resulting in differences in placental and fetal development.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Peripheral Vascular Disease
Kelsey McLaughlin, John W. Snelgrove, Melanie C. Audette, Atif Syed, Sebastian R. Hobson, Rory C. Windrim, Nir Melamed, Sergio Carmona, John C. Kingdom
Summary: This study evaluated the association between maternal PlGF levels and pregnancy outcomes in high-risk pregnancies, finding a strong correlation between low PlGF levels and adverse outcomes such as preterm birth, early-onset preeclampsia, and stillbirth.
Article
Oncology
Yves Boucher, Ashwin S. Kumar, Jessica M. Posada, Evisa Gjini, Kathleen Pfaff, Mikel Lipschitz, Ana Lako, Dan G. Duda, Scott J. Rodig, F. Stephen Hodi, Rakesh K. Jain
Summary: The study showed that a single dose of bevacizumab can reduce the density of angiopoietin-2-positive vessels and increase the infiltration of immune cells in patients with primary triple-negative breast cancer, suggesting a potential rationale for combining bevacizumab with immune checkpoint blockers in neoadjuvant treatment to improve efficacy.
NPJ PRECISION ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Annemarie J. Carver, Robert J. Taylor, Hanna E. Stevens
Summary: This paper describes a technique that uses CRISPR gene manipulation to directly alter placental gene expression, which can modify the expression of targeted genes. By performing a laparotomy on pregnant dams and delivering a CRISPR plasmid into the individual placentas, this technique allows for the evaluation of placenta and offspring development at a later time point, determining the role of time-specific placental function in development.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Cell Biology
Bing Yan, Zhu Mei, Yaohan Tang, Haixu Song, Hanlin Wu, Quanmin Jing, Xiaolin Zhang, Chenghui Yan, Yaling Han
Summary: This study aimed to determine the mechanism underlying the cardioprotective effects of FGF21. FGF21 knockout mice showed cardiac dysfunction and abnormal mitochondrial quality, quantity, and function. Cardiac-specific overexpression of FGF21 alleviated the cardiac dysfunction caused by FGF21 deficiency. In vitro studies showed that recombinant FGF21 could restore mitochondrial dynamics and function. FGF21 could be an important new target for therapeutic options for patients with heart failure.
CELL DEATH & DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Tariq R. Altamimi, Qutuba G. Karwi, Golam Mezbah Uddin, Arata Fukushima, Jennifer Q. Kwong, Jeffery D. Molkentin, Gary D. Lopaschuk
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2019)
Article
Multidisciplinary Sciences
Adam D. Kenney, Temet M. McMichael, Alexander Imas, Nicholas M. Chesarino, Lizhi Zhang, Lisa E. Dorn, Qian Wu, Omar Alfaour, Foued Amari, Min Chen, Ashley Zani, Mahesh Chemudupati, Federica Accornero, Vincenzo Coppola, Murugesan V. S. Rajaram, Jacob S. Yount
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Ronald J. Vagnozzi, Marjorie Maillet, Michelle A. Sargent, Hadi Khalil, Anne Katrine Z. Johansen, Jennifer A. Schwanekamp, Allen J. York, Vincent Huang, Matthias Nahrendorf, Sakthivel Sadayappan, Jeffery D. Molkentin
Article
Cardiac & Cardiovascular Systems
Georgios Amanakis, Junhui Sun, Maria M. Fergusson, Shane McGinty, Chengyu Liu, Jeffery D. Molkentin, Elizabeth Murphy
Summary: The study demonstrates that C202 plays a crucial role in the binding of CypD to PTP, with its oxidation state potentially regulating the opening of mitochondrial permeability transition pore. Mutating C202 reduces ischemia/reperfusion injury, and C202 is found to be S-nitrosylated during ischemic preconditioning.
CARDIOVASCULAR RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Salvatore Antonucci, Moises Di Sante, Justina Sileikyte, Jordan Deveraux, Tyler Bauer, Michael J. Bround, Roberta Menabo, Melanie Paillard, Petra Alanova, Michela Carraro, Michel Ovize, Jeffery D. Molkentin, Michael Cohen, Michael A. Forte, Paolo Bernardi, Fabio Di Lisa, Elizabeth Murphy
PHARMACOLOGICAL RESEARCH
(2020)
Article
Medicine, General & Internal
Ana Helena M. Pereira, Alisson C. Cardoso, Silvio R. Consonni, Renata R. Oliveira, Angela Saito, Maria Luisa B. Vaggione, Jose R. Matos-Souza, Marcelo F. Carazzolle, Anderson Goncalves, Juliano L. Fernandes, Gustavo C. A. Ribeiro, Mauricio M. Lopes, Jeffery D. Molkentin, Kleber G. Franchini
Letter
Cardiac & Cardiovascular Systems
Ronald J. Vagnozzi, Michelle A. Sargent, Jeffery D. Molkentin
Article
Cardiac & Cardiovascular Systems
Shan Lu, Zhandi Liao, Xiyuan Lu, Doerthe M. Katschinski, Mark Mercola, Ju Chen, Joan Heller Brown, Jeffery D. Molkentin, Julie Bossuyt, Donald M. Bers
CIRCULATION RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Jiuzhou Huo, Shan Lu, Jennifer Q. Kwong, Michael J. Bround, Kelly M. Grimes, Michelle A. Sargent, Milton E. Brown, Michael E. Davis, Donald M. Bers, Jeffery D. Molkentin
CIRCULATION RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Michael J. Bround, Donald M. Bers, Jeffery D. Molkentin
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2020)
Article
Medicine, Research & Experimental
Sonja C. Schriever, Dhiraj G. Kabra, Katrin Pfuhlmann, Peter Baumann, Emily Baumgart, Joachim Nagler, Fabian Seebacher, Luke Harrison, Martin Irmler, Stephanie Kullmann, Felipe Correa-da-Silva, Florian Giesert, Ruchi Jain, Hannah Schug, Julien Castel, Sarah Martinez, Moya Wu, Hans-Ulrich Haering, Martin Hrabe de Angelis, Johannes Beckers, Timo D. Mueller, Kerstin Stemmer, Wolfgang Wurst, Jan Rozman, Ruben Nogueiras, Meri De Angelis, Jeffery D. Molkentin, Natalie Krahmer, Chun-Xia Yi, Mathias Schmidt, Serge Luquet, Martin Heni, Matthias H. Tschoep, Paul T. Pfluger
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Multidisciplinary Sciences
Luis Hortells, Inigo Valiente-Alandi, Zachary M. Thomas, Emma J. Agnew, Dan J. Schnell, Allen J. York, Ronald J. Vagnozzi, Evan C. Meyer, Jeffery D. Molkentin, Katherine E. Yutzey
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Tobias Weinberger, Dena Esfandyari, Denise Messerer, Gulce Percin, Christian Schleifer, Raffael Thaler, Lulu Liu, Christopher Stremmel, Vanessa Schneider, Ronald J. Vagnozzi, Jennifer Schwanenkamp, Maximilian Fischer, Katrin Busch, Kay Klapproth, Hellen Ishikawa-Ankerhold, Lukas Kloesges, Anna Titova, Jeffery D. Molkentin, Yasuhiro Kobayashi, Stefan Engelhardt, Steffen Massberg, Claudia Waskow, Elisa Gomez Perdiguero, Christian Schulz
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Sonia R. Singh, Moritz Meyer-Jens, Erda Alizoti, W. Clark Bacon, Gregory Davis, Hanna Osinska, James Gulick, Silke Reischmann-Duesener, Ellen Orthey, Patrick M. McLendon, Jeffery D. Molkentin, Saskia Schlossarek, Jeffrey Robbins, Lucie Carrier
Summary: The study revealed that ZNF418 activates the ALP, inhibits the UPS, and regulates genes associated with cardiomyocyte structure and function. RNA-seq analysis showed that ZNF418 also plays a role in regulating genes involved in cardiac development and/or hypertrophy.
Article
Cardiac & Cardiovascular Systems
Talya Razin, Naomi Melamed-Book, Jasmin Argaman, Iris Galin, Yosef Lowy, Eli Anuka, Nili Naftali-Shani, Michal Kandel-Kfir, Benjamin P. Garfinkel, Shlomi Brielle, Zvi Granot, Ron N. Apte, Simon J. Conway, Jeffery D. Molkentin, Yehuda Kamari, Jonathan Leor, Joseph Orly
Summary: This study highlights the overlooked cellular responses evolved under stress conditions associated with the default inflammatory response to MI. The observations suggest that LV IL-1 alpha is cardioprotective through induction of StAR expression in border zone fibroblasts, rendering them resistant to apoptosis. This acquired survival feature has long-term ramifications on heart recovery post-MI by diminishing adverse remodeling and improving heart function.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)