Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types

Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis

(2021) Christopher D. Wiley et al.   Cell Metabolism

Discovery, Development, and Future Application of Senolytics: Theories and Predictions

(2020) Erin O. Wissler Gerdes et al.   FEBS Journal

Astrocyte senescence promotes glutamate toxicity in cortical neurons

(2020) Chandani Limbad et al.   PLoS One

Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors

(2020) Yuki Saito et al.   Nature Communications

Single-cell transcriptional profiles in human skeletal muscle

(2020) Aliza B. Rubenstein et al.   Scientific Reports

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

(2020) Estela González‐Gualda et al.   AGING CELL

Single-cell RNA sequencing identifies novel cell types in Drosophila blood

(2020) Yulong Fu et al.   Journal of Genetics and Genomics

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor

(2020) Shulong Zu et al.   CELL RESEARCH

Cholesterol 25‐Hydroxylase inhibits SARS ‐CoV‐2 and other coronaviruses by depleting membrane cholesterol

(2020) Shaobo Wang et al.   EMBO JOURNAL

MARS: discovering novel cell types across heterogeneous single-cell experiments

(2020) Maria Brbić et al.   NATURE METHODS

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

(2020) Ruochen Zang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

(2019) Rhys Anderson et al.   EMBO JOURNAL

Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors

(2019) Laura Lukjanenko et al.   Cell Stem Cell

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

(2019) Anna Walaszczyk et al.   AGING CELL

Senolytic therapies for healthy longevity

(2019) Jan M. van Deursen   SCIENCE

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

(2019) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools

(2019) Sebastian N. Knoppert et al.   Frontiers in Pharmacology

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Senescent cells and osteoarthritis: a painful connection

(2018) Ok Hee Jeon et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation

(2018) Khaled Greish et al.   MOLECULES

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest

(2018) Przemyslaw Sapieha et al.   TRENDS IN CELL BIOLOGY

Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment (“chemobrain”)

(2018) Jeriel T.R. Keeney et al.   Oncotarget

Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart

(2018) Daniel A. Skelly et al.   Cell Reports

Cellular senescence, geroscience, cancer and beyond

(2018) Francis Rodier et al.   Aging-US

A Single-Cell Transcriptional Atlas of the Developing Murine Cerebellum

(2018) Robert A. Carter et al.   CURRENT BIOLOGY

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury

(2018) Ruochen Qi et al.   Cell Death & Disease

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model

(2017) Chunfeng Li et al.   IMMUNITY

The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle

(2017) Koki Kamizaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Oxysterols in Human Cancer

(2017) Alzbeta Kloudova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

RNF7 knockdown inhibits prostate cancer tumorigenesis by inactivation of ERK1/2 pathway

(2017) Yangjiong Xiao et al.   Scientific Reports

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

Lipoprotein lipase and phospholipid transfer protein overexpression in human glioma cells and their effect on cell growth, apoptosis, and migration

(2016) Weijiang Dong et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Markers of cellular senescence. Telomere shortening as a marker of cellular senescence

(2016) Alexandra Bernadotte et al.   Aging-US

Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction

(2016) Laura A. A. Gilliam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signalings

(2016) Concetta Panebianco et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases

(2016) Yingying Wang et al.   RADIATION RESEARCH

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner

(2016) Hitoshi Nishizawa et al.   Scientific Reports

Alpha B-crystallin induction in skeletal muscle cells under redox imbalance is mediated by a JNK-dependent regulatory mechanism

(2015) Simona Fittipaldi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulfiredoxin-1 exerts anti-apoptotic and neuroprotective effects against oxidative stress-induced injury in rat cortical astrocytes following exposure to oxygen-glucose deprivation and hydrogen peroxide

(2015) YUNCHUAN ZHOU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

FoxO3a suppresses the senescence of cardiac microvascular endothelial cells by regulating the ROS-mediated cell cycle

(2015) Xu-Feng Qi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Single-cell messenger RNA sequencing reveals rare intestinal cell types

(2015) Dominic Grün et al.   NATURE

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting

(2015) Ling Liu et al.   Nature Protocols

Pharmacological chaperone for  -crystallin partially restores transparency in cataract models

(2015) L. N. Makley et al.   SCIENCE

Discovery of structure-based small molecular inhibitor of αB-crystallin against basal-like/triple-negative breast cancer development in vitro and in vivo

(2014) Zhijuan Chen et al.   BREAST CANCER RESEARCH AND TREATMENT

Knockdown of response gene to complement 32 (RGC32) induces apoptosis and inhibits cell growth, migration, and invasion in human lung cancer cells

(2014) Ran Xu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

25-Hydroxycholesterol acts as an amplifier of inflammatory signaling

(2014) E. S. Gold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Crystallin B prevents apoptosis after H2O2 exposure in mouse neonatal cardiomyocytes

(2012) Roxana Chis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

(2012) Su-Yang Liu et al.   IMMUNITY

A Novel, “Double-Clamp” Binding Mode for Human Heme Oxygenase-1 Inhibition

(2012) Mona N. Rahman et al.   PLoS One

Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase

(2012) Yi Sun et al.   Protein & Cell

Heme Oxygenase-1, Oxidation, Inflammation, and Atherosclerosis

(2012) Jesus A. Araujo et al.   Frontiers in Pharmacology

Mesangial Cell Integrin αvβ8 Provides Glomerular Endothelial Cell Cytoprotection by Sequestering TGF-β and Regulating PECAM-1

(2011) Shenaz Khan et al.   AMERICAN JOURNAL OF PATHOLOGY

Chemotherapy-Induced Weakness and Fatigue in Skeletal Muscle: The Role of Oxidative Stress

(2011) Laura A.A. Gilliam et al.   ANTIOXIDANTS & REDOX SIGNALING

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

(2010) Akiyoshi Uezumi et al.   NATURE CELL BIOLOGY

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

(2010) Aaron W. B. Joe et al.   NATURE CELL BIOLOGY

Direct effects of doxorubicin on skeletal muscle contribute to fatigue

(2009) K van Norren et al.   BRITISH JOURNAL OF CANCER

A Novel Experimental Heme Oxygenase-1-Targeted Therapy for Hormone-Refractory Prostate Cancer

(2009) M. A. Alaoui-Jamali et al.   CANCER RESEARCH

Doxorubicin Cardiomyopathy

(2009) Kanu Chatterjee et al.   CARDIOLOGY

Caveolin-1 promotes resistance to chemotherapy-induced apoptosis in Ewing's sarcoma cells by modulating PKCα phosphorylation

(2009) Oscar M. Tirado et al.   INTERNATIONAL JOURNAL OF CANCER

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

(2009) R.F. Loeser   OSTEOARTHRITIS AND CARTILAGE

A Link between FXYD3 (Mat-8)-mediated Na,K-ATPase Regulation and Differentiation of Caco-2 Intestinal Epithelial Cells

(2008) Stéphanie Bibert et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation of caveolin-1 is anti-apoptotic and promotes cell attachment during oxidative stress of kidney cells

(2008) Christine J. Percy et al.   PATHOLOGY